1ZTJ

Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with 2-(5-Benzylamino-2-methylsulfanyl-6-oxo-6H-pyrimidin-1-yl)-N-[4-guanidino-1-(thiazole-2-carbonyl)-butyl]-acetamide

Summary for 1ZTJ

• Entry DOI: 10.2210/pdb1ztj/pdb
• Descriptor: Coagulation factor XI, SULFATE ION, BICARBONATE ION, ... (5 entities in total)
• Functional Keywords: fxia, inhibitors, hydrolase
• Biological source: Homo sapiens (human)
• Cellular location: Secreted: P03951
• Total number of polymer chains: 1
• Total formula weight: 27534.16

Authors

Nagafuji, P.,Jin, L.,Rynkiewicz, M.,Quinn, J.,Bibbins, F.,Meyers, H.,Babine, R.E.,Strickler, J.E.,Abdel-Meguid, S.S. (deposition date: 2005-05-27, release date: 2006-05-09, Last modification date: 2023-08-23)

• Primary citation: Nagafuji, P.,Jin, L.,Rynkiewicz, M.,Quinn, J.,Bibbins, F.,Meyers, H.,Babine, R.E.,Strickler, J.E.,Abdel-Meguid, S.S.; Pyrimidinone Inhibitors of a Thrombolytic Protease; To be Published,

Experimental method

X-RAY DIFFRACTION (2.05 Å)