1ZTJ
Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with 2-(5-Benzylamino-2-methylsulfanyl-6-oxo-6H-pyrimidin-1-yl)-N-[4-guanidino-1-(thiazole-2-carbonyl)-butyl]-acetamide
Summary for 1ZTJ
Entry DOI | 10.2210/pdb1ztj/pdb |
Descriptor | Coagulation factor XI, SULFATE ION, BICARBONATE ION, ... (5 entities in total) |
Functional Keywords | fxia, inhibitors, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Secreted: P03951 |
Total number of polymer chains | 1 |
Total formula weight | 27534.16 |
Authors | Nagafuji, P.,Jin, L.,Rynkiewicz, M.,Quinn, J.,Bibbins, F.,Meyers, H.,Babine, R.E.,Strickler, J.E.,Abdel-Meguid, S.S. (deposition date: 2005-05-27, release date: 2006-05-09, Last modification date: 2023-08-23) |
Primary citation | Nagafuji, P.,Jin, L.,Rynkiewicz, M.,Quinn, J.,Bibbins, F.,Meyers, H.,Babine, R.E.,Strickler, J.E.,Abdel-Meguid, S.S. Pyrimidinone Inhibitors of a Thrombolytic Protease To be Published, |
Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
Download full validation report