8AQM
Crystal structure of PPARG and NCOR2 with an inverse agonist (compound 6a)
Summary for 8AQM
Entry DOI | 10.2210/pdb8aqm/pdb |
Descriptor | Peroxisome proliferator-activated receptor gamma, Nuclear receptor corepressor 2, 2-chloranyl-~{N}-[2-(3-methylphenyl)-1,3-benzoxazol-5-yl]-5-nitro-benzamide, ... (4 entities in total) |
Functional Keywords | nuclear hormone receptor transcription factor, transcription |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 69817.75 |
Authors | Friberg, A.,Orsi, D.L.,Pook, E.,Braeuer, N.,Lemke, C.T.,Stellfeld, T.,Puetter, V.,Goldstein, J. (deposition date: 2022-08-12, release date: 2022-11-09, Last modification date: 2022-12-28) |
Primary citation | Orsi, D.L.,Pook, E.,Brauer, N.,Friberg, A.,Lienau, P.,Lemke, C.T.,Stellfeld, T.,Bruggemeier, U.,Putter, V.,Meyer, H.,Baco, M.,Tang, S.,Cherniack, A.D.,Westlake, L.,Bender, S.A.,Kocak, M.,Strathdee, C.A.,Meyerson, M.,Eis, K.,Goldstein, J.T. Discovery and Structure-Based Design of Potent Covalent PPAR gamma Inverse-Agonists BAY-4931 and BAY-0069 . J.Med.Chem., 65:14843-14863, 2022 Cited by PubMed: 36270630DOI: 10.1021/acs.jmedchem.2c01379 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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