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6E1F
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CRYSTAL STRUCTURE OF THE SWIRM DOMAIN OF HUMAN HISTONE LYSINE-SPECIFIC DEMETHYLASE LSD1
Descriptor:Lysine-specific histone demethylase 1A, SULFATE ION
Authors:Luka, Z., Pakhomova, S., Reiter, N.J.
Deposit date:2018-07-09
Release date:2019-07-10
Method:X-RAY DIFFRACTION (1.16 Å)
Cite:Transient and highly ordered structural domains exist within the N-terminus of LSD1 and differentially interact with mononucleosomes
To be Published
3MF6
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COMPUTATIONALLY DESIGNED ENDO-1,4-BETA-XYLANASE
Descriptor:Endo-1,4-beta-xylanase, SULFATE ION
Authors:Morin, A., Harp, J.M.
Deposit date:2010-04-01
Release date:2010-11-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.28 Å)
Cite:Computational design of an endo-1,4-{beta}-xylanase ligand binding site.
Protein Eng.Des.Sel., 24, 2011
3TDN
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COMPUTATIONALLY DESIGNED TWO-FOLD SYMMETRIC TIM-BARREL PROTEIN, FLR
Descriptor:FLR SYMMETRIC ALPHA-BETA TIM BARREL
Authors:Harp, J.M., Fortenberry, C., Bowman, E., Profitt, W., Dorr, B., Mizoue, L., Meiler, J.
Deposit date:2011-08-11
Release date:2011-11-16
Last modified:2011-11-23
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Exploring symmetry as an avenue to the computational design of large protein domains.
J.Am.Chem.Soc., 133, 2011
3MFA
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COMPUTATIONALLY DESIGNED ENDO-1,4-BETA-XYLANASE
Descriptor:Endo-1,4-beta-xylanase, SULFATE ION
Authors:Morin, A., Harp, J.M.
Deposit date:2010-04-01
Release date:2010-11-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Computational design of an endo-1,4-{beta}-xylanase ligand binding site.
Protein Eng.Des.Sel., 24, 2011
3MF9
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COMPUTATIONALLY DESIGNED ENDO-1,4-BETA-XYLANASE
Descriptor:Endo-1,4-beta-xylanase, SULFATE ION
Authors:Morin, A., Harp, J.M.
Deposit date:2010-04-01
Release date:2010-11-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Computational design of an endo-1,4-{beta}-xylanase ligand binding site.
Protein Eng.Des.Sel., 24, 2011
3MFC
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COMPUTATIONALLY DESIGNED END0-1,4-BETA,XYLANASE
Descriptor:Endo-1,4-beta-xylanase, SULFATE ION
Authors:Morin, A., Harp, J.M.
Deposit date:2010-04-01
Release date:2010-11-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Computational design of an endo-1,4-{beta}-xylanase ligand binding site.
Protein Eng.Des.Sel., 24, 2011
5KDO
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HETEROTRIMERIC COMPLEX OF THE 4 ALANINE INSERTION VARIANT OF THE GI ALPHA1 SUBUNIT AND THE GBETA1-GGAMMA1
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(T) subunit gamma-T1, ...
Authors:Kaya, A.I., Lokits, A.D., Gilbert, J., Iverson, T.M., Meiler, J., Hamm, H.E.
Deposit date:2016-06-08
Release date:2016-08-03
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A Conserved Hydrophobic Core in G alpha i1 Regulates G Protein Activation and Release from Activated Receptor.
J.Biol.Chem., 291, 2016
5TQL
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CRYSTAL STRUCTURE OF TIM-BARREL PROTEIN HISF-C9S
Descriptor:Imidazole glycerol phosphate synthase subunit HisF, PHOSPHATE ION
Authors:Bender, B.J., Meiler, J.
Deposit date:2016-10-24
Release date:2016-11-16
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Experimental and Computational Identification of Naive Binders to a TIM-Barrel Protein Scaffold
To Be Published
5BOP
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CRYSTAL STRUCTURE OF THE ARTIFICIAL NANOBODY OCTARELLINV.1 COMPLEX
Descriptor:Nanobody, Octarellin V.1
Authors:Figueroa, M., Sleutel, M., Pardon, E., Steyaert, J., Martial, J.A., van de Weerdt, C.
Deposit date:2015-05-27
Release date:2016-05-25
Last modified:2016-06-08
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The unexpected structure of the designed protein Octarellin V.1 forms a challenge for protein structure prediction tools.
J.Struct.Biol., 195, 2016
4PAQ
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A CONSERVED PHENYLALANINE AS RELAY BETWEEN THE 5 HELIX AND THE GDP BINDING REGION OF HETEROTRIMERIC G PROTEIN
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION
Authors:Kaya, A.I., Lokits, A.D., Gilbert, J., Iverson, T.M., Meiler, J., Hamm, H.E.
Deposit date:2014-04-09
Release date:2014-07-30
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:A Conserved Phenylalanine as a Relay between the alpha 5 Helix and the GDP Binding Region of Heterotrimeric Gi Protein alpha Subunit.
J.Biol.Chem., 289, 2014
5ITB
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CRYSTAL STRUCTURE OF THE ANTI-RSV F FAB 14N4
Descriptor:anti-RSV F Fab 14N4 Heavy chain, anti-RSV F Fab 14N4 Light chain
Authors:Mousa, J.J., Crowe, J.E.
Deposit date:2016-03-16
Release date:2016-10-26
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for nonneutralizing antibody competition at antigenic site II of the respiratory syncytial virus fusion protein.
Proc.Natl.Acad.Sci.USA, 113, 2016
5JRP
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CRYSTAL STRUCTURE OF MONOCLONAL ANTIBODY MR78 FAB
Descriptor:marberg virus monoclonal antibody MR78 Fab light chain, marberg virus monoclonal antibody MR78 Fab heavy chain, SODIUM ION
Authors:Dong, J., Crowe, J.
Deposit date:2016-05-06
Release date:2017-11-08
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Role of Non-local Interactions between CDR Loops in Binding Affinity of MR78 Antibody to Marburg Virus Glycoprotein.
Structure, 25, 2017
5WEQ
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THE CRYSTAL STRUCTURE OF A MR78 MUTANT
Descriptor:MR78 mutant light chain, MR78 mutant Fab heavy chain
Authors:Dong, J., Williamson, L.E., Crowe, J.E.
Deposit date:2017-07-10
Release date:2018-04-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Role of Non-local Interactions between CDR Loops in Binding Affinity of MR78 Antibody to Marburg Virus Glycoprotein.
Structure, 25, 2017
4PAO
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A CONSERVED PHENYLALANINE AS RELAY BETWEEN THE 5 HELIX AND THE GDP BINDING REGION OF HETEROTRIMERIC G PROTEIN
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION
Authors:Kaya, A.I., Lokits, A.D., Gilbert, J., Iverson, T.M., Meiler, J., Hamm, H.E.
Deposit date:2014-04-09
Release date:2014-07-30
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.003 Å)
Cite:A Conserved Phenylalanine as a Relay between the alpha 5 Helix and the GDP Binding Region of Heterotrimeric Gi Protein alpha Subunit.
J.Biol.Chem., 289, 2014
4PAM
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A CONSERVED PHENYLALANINE AS RELAY BETWEEN THE 5 HELIX AND THE GDP BINDING REGION OF HETEROTRIMERIC G PROTEIN
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, GUANOSINE-5'-DIPHOSPHATE, SULFITE ION, ...
Authors:Kaya, A.I., Lokits, A.D., Gilbert, J., Iverson, T.M., Meiler, J., Hamm, H.E.
Deposit date:2014-04-09
Release date:2014-07-30
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.101 Å)
Cite:A Conserved Phenylalanine as a Relay between the alpha 5 Helix and the GDP Binding Region of Heterotrimeric Gi Protein alpha Subunit.
J.Biol.Chem., 289, 2014
4ZV6
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CRYSTAL STRUCTURE OF THE ARTIFICIAL ALPHAREP-7 OCTARELLINV.1 COMPLEX
Descriptor:AlphaRep-7, Octarellin V.1
Authors:Figueroa, M., Sleutel, M., Urvoas, A., Valerio-Lepiniec, M., Minard, P., Martial, J.A., van de Weerdt, C.
Deposit date:2015-05-18
Release date:2016-05-25
Last modified:2016-06-08
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:The unexpected structure of the designed protein Octarellin V.1 forms a challenge for protein structure prediction tools.
J.Struct.Biol., 195, 2016
4GSD
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H5.3 FAB STRUCTURE
Descriptor:H5.3 Fab Light Chain, H5.3 Fab Heavy Chain
Authors:Spiller, B.W., Winarski, K.L.
Deposit date:2012-08-27
Release date:2013-08-21
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.251 Å)
Cite:Human antibodies that neutralize respiratory droplet transmissible H5N1 influenza viruses.
J.Clin.Invest., 123, 2013
4YAQ
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CRYSTAL STRUCTURE OF A COMPUTATIONALLY OPTIMIZED PG9 MUTANT
Descriptor:PG9_N100FY Fab heavy chain, PG9_N100FY Light Chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ...
Authors:Murrell, S., Julien, J.P., Wilson, I.A.
Deposit date:2015-02-17
Release date:2015-06-03
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Redesigned HIV antibodies exhibit enhanced neutralizing potency and breadth.
J.Clin.Invest., 125, 2015
4ZWQ
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CRYSTAL STRUCTURE OF THE BACTERIOPHAGE T4 RECOMBINATION MEDIATOR PROTEIN UVSY, LATTICE TYPE I
Descriptor:Recombination protein uvsY
Authors:Gajewski, S., White, S.W.
Deposit date:2015-05-19
Release date:2016-03-02
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.351 Å)
Cite:Structure and mechanism of the phage T4 recombination mediator protein UvsY.
Proc.Natl.Acad.Sci.USA, 113, 2016
3TDM
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COMPUTATIONALLY DESIGNED TIM-BARREL PROTEIN, HALFFLR
Descriptor:Computationally designed two-fold symmetric TIM-barrel protein, FLR (half molecule), PHOSPHATE ION
Authors:Harp, J.M., Fortenberry, C., Bowman, E., Profitt, W., Dorr, B., Mizoue, L.
Deposit date:2011-08-11
Release date:2011-11-16
Last modified:2011-11-23
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Exploring symmetry as an avenue to the computational design of large protein domains.
J.Am.Chem.Soc., 133, 2011
4PAN
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A CONSERVED PHENYLALANINE AS RELAY BETWEEN THE 5 HELIX AND THE GDP BINDING REGION OF HETEROTRIMERIC G PROTEIN
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, GUANOSINE-5'-DIPHOSPHATE, SULFITE ION, ...
Authors:Kaya, A.I., Lokits, A.D., Gilbert, J., Iverson, T.M., Meiler, J., Hamm, H.E.
Deposit date:2014-04-09
Release date:2014-07-30
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A Conserved Phenylalanine as a Relay between the alpha 5 Helix and the GDP Binding Region of Heterotrimeric Gi Protein alpha Subunit.
J.Biol.Chem., 289, 2014
4ZWS
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CRYSTAL STRUCTURE OF THE BACTERIOPHAGE T4 RECOMBINATION MEDIATOR PROTEIN UVSY, LATTICE TYPE III
Descriptor:Recombination protein uvsY
Authors:Gajewski, S., White, S.W.
Deposit date:2015-05-19
Release date:2016-03-02
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure and mechanism of the phage T4 recombination mediator protein UvsY.
Proc.Natl.Acad.Sci.USA, 113, 2016
4HFW
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ANTI ROTAVIRUS ANTIBODY
Descriptor:6-26 Fab Light chain, 6-26 Fab Heavy chain, SULFATE ION
Authors:Spiller, B.W., Aiyegbo, M., Crowe, J.E.
Deposit date:2012-10-05
Release date:2013-05-29
Method:X-RAY DIFFRACTION (2.601 Å)
Cite:Human Rotavirus VP6-Specific Antibodies Mediate Intracellular Neutralization by Binding to a Quaternary Structure in the Transcriptional Pore.
Plos One, 8, 2013
5KDL
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CRYSTAL STRUCTURE OF THE 4 ALANINE INSERTION VARIANT OF THE GI ALPHA1 SUBUNIT BOUND TO GTPGAMMAS
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, MAGNESIUM ION, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE
Authors:Kaya, A.I., Lokits, A.D., Gilbert, J., Iverson, T.M., Meiler, J., Hamm, H.E.
Deposit date:2016-06-08
Release date:2016-08-03
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.665 Å)
Cite:A Conserved Hydrophobic Core in G alpha i1 Regulates G Protein Activation and Release from Activated Receptor.
J.Biol.Chem., 291, 2016
5ZBQ
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THE CRYSTAL STRUCTURE OF HUMAN NEUROPEPTIDE Y Y1 RECEPTOR WITH UR-MK299
Descriptor:Neuropeptide Y receptor type 1,T4 Lysozyme, N~2~-(diphenylacetyl)-N-[(4-hydroxyphenyl)methyl]-N~5~-(N'-{[2-(propanoylamino)ethyl]carbamoyl}carbamimidoyl)-D-ornithinamide
Authors:Yang, Z., Han, S., Zhao, Q., Wu, B.
Deposit date:2018-02-12
Release date:2018-04-25
Last modified:2018-05-09
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis of ligand binding modes at the neuropeptide Y Y1receptor
Nature, 556, 2018
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