4PAN

A conserved phenylalanine as relay between the 5 helix and the GDP binding region of heterotrimeric G protein

Summary for 4PAN

Related4PAM 4PAO 4PAQ
DescriptorGuanine nucleotide-binding protein G(i) subunit alpha-1, GUANOSINE-5'-DIPHOSPHATE, SULFITE ION, ... (5 entities in total)
Functional Keywordsactivation of heterotrimeric g protein, gdp release, computer modeling, g protein coupled receptors, rhodopsin, signaling protein
Biological sourceRattus norvegicus (Rat)
Cellular locationNucleus P10824
Total number of polymer chains1
Total molecular weight40973.75
Authors
Kaya, A.I.,Lokits, A.D.,Gilbert, J.,Iverson, T.M.,Meiler, J.,Hamm, H.E. (deposition date: 2014-04-09, release date: 2014-07-30, Last modification date: 2017-09-13)
Primary citation
Kaya, A.I.,Lokits, A.D.,Gilbert, J.A.,Iverson, T.M.,Meiler, J.,Hamm, H.E.
A Conserved Phenylalanine as a Relay between the alpha 5 Helix and the GDP Binding Region of Heterotrimeric Gi Protein alpha Subunit.
J.Biol.Chem., 289:24475-24487, 2014
PubMed: 25037222 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M114.572875
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.4 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.233401.1%2.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution