Computationally designed two-fold symmetric Tim-barrel protein, FLR

Summary for 3TDN

DescriptorFLR SYMMETRIC ALPHA-BETA TIM BARREL (2 entities in total)
Functional Keywordssymmetric superfold, tim-barrel, de novo protein
Biological sourcesynthetic construct (artificial gene)
Total number of polymer chains2
Total molecular weight53394.94
Harp, J.M.,Fortenberry, C.,Bowman, E.,Profitt, W.,Dorr, B.,Mizoue, L.,Meiler, J. (deposition date: 2011-08-11, release date: 2011-11-16, Last modification date: 2011-11-23)
Primary citation
Fortenberry, C.,Bowman, E.A.,Proffitt, W.,Dorr, B.,Combs, S.,Harp, J.,Mizoue, L.,Meiler, J.
Exploring symmetry as an avenue to the computational design of large protein domains.
J.Am.Chem.Soc., 133:18026-18029, 2011
PubMed: 21978247 (PDB entries with the same primary citation)
DOI: 10.1021/ja2051217
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.19840.3%1.7%2.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution