Structural Basis for KCNE3 and Estrogen Modulation of the KCNQ1 Channel

Summary for 2NDJ

DescriptorPotassium voltage-gated channel subfamily E member 3 (1 entity in total)
Functional Keywordsestrogen, membrane protein, ion channel
Biological sourceHomo sapiens (human)
Cellular locationCell membrane ; Single-pass type I membrane protein  Q9Y6H6
Total number of polymer chains1
Total molecular weight12799.58
Sanders, C.R.,Van Horn, W.D.,Kroncke, B.M.,Sisco, N.J.,Meiler, J.,Vanoye, C.G.,Song, Y.,Nannemann, D.P.,Welch, R.C.,Kang, C.,Smith, J.,George, A.L. (deposition date: 2016-06-09, release date: 2016-09-21, Last modification date: 2017-12-20)
Primary citation
Kroncke, B.M.,Van Horn, W.D.,Smith, J.,Kang, C.,Welch, R.C.,Song, Y.,Nannemann, D.P.,Taylor, K.C.,Sisco, N.J.,George, A.L.,Meiler, J.,Vanoye, C.G.,Sanders, C.R.
Structural basis for KCNE3 modulation of potassium recycling in epithelia.
Sci Adv, 2:e1501228-e1501228, 2016
PubMed: 27626070 (PDB entries with the same primary citation)
DOI: 10.1126/sciadv.1501228
MImport into Mendeley
Experimental method
NMR Information

Structure validation

ClashscoreRamachandran outliersSidechain outliers00.2%7.1%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures