2NDJ

Structural Basis for KCNE3 and Estrogen Modulation of the KCNQ1 Channel

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005249	molecular_function	voltage-gated potassium channel activity
A	0005251	molecular_function	delayed rectifier potassium channel activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006813	biological_process	potassium ion transport
A	0006814	biological_process	sodium ion transport
A	0008076	cellular_component	voltage-gated potassium channel complex
A	0015459	molecular_function	potassium channel regulator activity
A	0016020	cellular_component	membrane
A	0030425	cellular_component	dendrite
A	0030644	biological_process	intracellular chloride ion homeostasis
A	0031982	cellular_component	vesicle
A	0032809	cellular_component	neuronal cell body membrane
A	0042995	cellular_component	cell projection
A	0043204	cellular_component	perikaryon
A	0043266	biological_process	regulation of potassium ion transport
A	0044325	molecular_function	transmembrane transporter binding
A	0045121	cellular_component	membrane raft
A	0060307	biological_process	regulation of ventricular cardiac muscle cell membrane repolarization
A	0071805	biological_process	potassium ion transmembrane transport
A	0086005	biological_process	ventricular cardiac muscle cell action potential
A	0086011	biological_process	membrane repolarization during action potential
A	0086091	biological_process	regulation of heart rate by cardiac conduction
A	0097623	biological_process	potassium ion export across plasma membrane
A	0098915	biological_process	membrane repolarization during ventricular cardiac muscle cell action potential
A	1902260	biological_process	negative regulation of delayed rectifier potassium channel activity
A	1902282	molecular_function	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
A	1903765	biological_process	negative regulation of potassium ion export across plasma membrane
A	1905025	biological_process	negative regulation of membrane repolarization during ventricular cardiac muscle cell action potential
A	1990794	cellular_component	basolateral part of cell

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"31883792","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6V01","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	25
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	21
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	11
Details	Region: {"description":"Interaction with KCNQ1","evidences":[{"source":"PubMed","id":"31883792","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	10
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---