A conserved phenylalanine as relay between the 5 helix and the GDP binding region of heterotrimeric G protein

Summary for 4PAO

Related4PAN 4PAM 4PAQ
DescriptorGuanine nucleotide-binding protein G(i) subunit alpha-1, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, ... (4 entities in total)
Functional Keywordsactivation of heterotrimeric g protein gdp release, computer modeling, g protein coupled receptors, rhodopsin, signaling protein
Biological sourceRattus norvegicus (Rat)
Cellular locationNucleus P10824
Total number of polymer chains1
Total molecular weight40918.55
Kaya, A.I.,Lokits, A.D.,Gilbert, J.,Iverson, T.M.,Meiler, J.,Hamm, H.E. (deposition date: 2014-04-09, release date: 2014-07-30, Last modification date: 2017-11-22)
Primary citation
Kaya, A.I.,Lokits, A.D.,Gilbert, J.A.,Iverson, T.M.,Meiler, J.,Hamm, H.E.
A Conserved Phenylalanine as a Relay between the alpha 5 Helix and the GDP Binding Region of Heterotrimeric Gi Protein alpha Subunit.
J.Biol.Chem., 289:24475-24487, 2014
PubMed: 25037222 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M114.572875
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.208200.4%0.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution