Author results

6D0U
  • Download 6d0u
  • View 6d0u
Molmil generated image of 6d0u
CRYSTAL STRUCTURE OF C05 V110P/A117E MUTANT BOUND TO H3 INFLUENZA HEMAGGLUTININ, HA1 SUBUNIT
Descriptor:Hemagglutinin, Antibody C05 V110P/A117E mutant, heavy chain, ...
Authors:Wu, N.C., Wilson, I.A.
Deposit date:2018-04-11
Release date:2019-01-16
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Multistate design of influenza antibodies improves affinity and breadth against seasonal viruses.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
5ZBQ
  • Download 5zbq
  • View 5zbq
Molmil generated image of 5zbq
THE CRYSTAL STRUCTURE OF HUMAN NEUROPEPTIDE Y Y1 RECEPTOR WITH UR-MK299
Descriptor:Neuropeptide Y receptor type 1,T4 Lysozyme, N~2~-(diphenylacetyl)-N-[(4-hydroxyphenyl)methyl]-N~5~-(N'-{[2-(propanoylamino)ethyl]carbamoyl}carbamimidoyl)-D-ornithinamide
Authors:Yang, Z., Han, S., Zhao, Q., Wu, B.
Deposit date:2018-02-12
Release date:2018-04-25
Last modified:2018-05-09
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis of ligand binding modes at the neuropeptide Y Y1receptor
Nature, 556, 2018
5ZBH
  • Download 5zbh
  • View 5zbh
Molmil generated image of 5zbh
THE CRYSTAL STRUCTURE OF HUMAN NEUROPEPTIDE Y Y1 RECEPTOR WITH BMS-193885
Descriptor:Neuropeptide Y receptor type 1,T4 Lysozyme,Neuropeptide Y receptor type 1, dimethyl 4-{3-[({3-[4-(3-methoxyphenyl)piperidin-1-yl]propyl}carbamoyl)amino]phenyl}-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
Authors:Yang, Z., Han, S., Zhao, Q., Wu, B.
Deposit date:2018-02-11
Release date:2018-04-25
Last modified:2018-05-09
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural basis of ligand binding modes at the neuropeptide Y Y1receptor
Nature, 556, 2018
6F3V
  • Download 6f3v
  • View 6f3v
Molmil generated image of 6f3v
BACKBONE STRUCTURE OF BRADYKININ (BK) PEPTIDE BOUND TO HUMAN BRADYKININ 2 RECEPTOR (B2R) DETERMINED BY MAS SSNMR
Descriptor:Bradykinin (BK)
Authors:Mao, J., Lopez, J.J., Shukla, A.K., Kuenze, G., Meiler, J., Schwalbe, H., Michel, H., Glaubitz, C.
Deposit date:2017-11-29
Release date:2018-01-10
Last modified:2018-02-21
Method:SOLID-STATE NMR
Cite:The molecular basis of subtype selectivity of human kinin G-protein-coupled receptors.
Nat. Chem. Biol., 14, 2018
6F3W
  • Download 6f3w
  • View 6f3w
Molmil generated image of 6f3w
BACKBONE STRUCTURE OF FREE BRADYKININ (BK) IN DDM/CHS DETERGENT MICELLE DETERMINED BY MAS SSNMR
Descriptor:Kininogen-1
Authors:Mao, J., Lopez, J.J., Shukla, A.K., Kuenze, G., Meiler, J., Schwalbe, H., Michel, H., Glaubitz, C.
Deposit date:2017-11-29
Release date:2018-01-10
Last modified:2018-02-21
Method:SOLID-STATE NMR
Cite:The molecular basis of subtype selectivity of human kinin G-protein-coupled receptors.
Nat. Chem. Biol., 14, 2018
6F3X
  • Download 6f3x
  • View 6f3x
Molmil generated image of 6f3x
BACKBONE STRUCTURE OF DES-ARG10-KALLIDIN (DAKD) PEPTIDE IN FROZEN DDM/CHS DETERGENT MICELLE SOLUTION DETERMINED BY DNP-ENHANCED MAS SSNMR
Descriptor:Kininogen-1
Authors:Mao, J., Kuenze, G., Joedicke, L., Meiler, J., Michel, H., Glaubitz, C.
Deposit date:2017-11-29
Release date:2018-01-10
Last modified:2018-02-21
Method:SOLID-STATE NMR
Cite:The molecular basis of subtype selectivity of human kinin G-protein-coupled receptors.
Nat. Chem. Biol., 14, 2018
6F3Y
  • Download 6f3y
  • View 6f3y
Molmil generated image of 6f3y
BACKBONE STRUCTURE OF DES-ARG10-KALLIDIN (DAKD) PEPTIDE BOUND TO HUMAN BRADYKININ 1 RECEPTOR (B1R) DETERMINED BY DNP-ENHANCED MAS SSNMR
Descriptor:Kininogen-1
Authors:Mao, J., Kuenze, G., Joedicke, L., Meiler, J., Michel, H., Glaubitz, C.
Deposit date:2017-11-29
Release date:2018-01-10
Last modified:2018-02-21
Method:SOLID-STATE NMR
Cite:The molecular basis of subtype selectivity of human kinin G-protein-coupled receptors.
Nat. Chem. Biol., 14, 2018
6F27
  • Download 6f27
  • View 6f27
Molmil generated image of 6f27
NMR SOLUTION STRUCTURE OF NON-BOUND [DES-ARG10]-KALLIDIN (DAKD)
Descriptor:DAKD
Authors:Richter, C., Jonker, H.R.A., Schwalbe, H., Joedicke, L., Mao, J., Kuenze, G., Reinhart, C., Kalavacherla, T., Meiler, J., Preu, J., Michel, H., Glaubitz, C.
Deposit date:2017-11-23
Release date:2018-01-10
Last modified:2019-05-08
Method:SOLUTION NMR
Cite:The molecular basis of subtype selectivity of human kinin G-protein-coupled receptors.
Nat. Chem. Biol., 14, 2018
6BP2
  • Download 6bp2
  • View 6bp2
Molmil generated image of 6bp2
THERAPEUTIC HUMAN MONOCLONAL ANTIBODY MR191 BOUND TO A MARBURGVIRUS GLYCOPROTEIN
Descriptor:Envelope glycoprotein, Envelope glycoprotein GP2, MR191 Fab Heavy Chain, ...
Authors:King, L.B., Fusco, M.L., Flyak, A.I., Ilinykh, P.A., Huang, K., Gunn, B., Kirchdoerfer, R.N., Hastie, K.M., Sangha, A.K., Meiler, J., Alter, G., Bukreyev, A., Crowe, J.E.J., Saphire, E.O.
Deposit date:2017-11-21
Release date:2018-01-17
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (3.172 Å)
Cite:The Marburgvirus-Neutralizing Human Monoclonal Antibody MR191 Targets a Conserved Site to Block Virus Receptor Binding.
Cell Host Microbe, 23, 2018
5WEQ
  • Download 5weq
  • View 5weq
Molmil generated image of 5weq
THE CRYSTAL STRUCTURE OF A MR78 MUTANT
Descriptor:MR78 mutant light chain, MR78 mutant Fab heavy chain
Authors:Dong, J., Williamson, L.E., Crowe, J.E.
Deposit date:2017-07-10
Release date:2018-04-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Role of Non-local Interactions between CDR Loops in Binding Affinity of MR78 Antibody to Marburg Virus Glycoprotein.
Structure, 25, 2017
5TQL
  • Download 5tql
  • View 5tql
Molmil generated image of 5tql
CRYSTAL STRUCTURE OF TIM-BARREL PROTEIN HISF-C9S
Descriptor:Imidazole glycerol phosphate synthase subunit HisF, PHOSPHATE ION
Authors:Bender, B.J., Meiler, J.
Deposit date:2016-10-24
Release date:2016-11-16
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Experimental and Computational Identification of Naive Binders to a TIM-Barrel Protein Scaffold
To Be Published
2NDJ
  • Download 2ndj
  • View 2ndj
Molmil generated image of 2ndj
STRUCTURAL BASIS FOR KCNE3 AND ESTROGEN MODULATION OF THE KCNQ1 CHANNEL
Descriptor:Potassium voltage-gated channel subfamily E member 3
Authors:Sanders, C.R., Van Horn, W.D., Kroncke, B.M., Sisco, N.J., Meiler, J., Vanoye, C.G., Song, Y., Nannemann, D.P., Welch, R.C., Kang, C., Smith, J., George, A.L.
Deposit date:2016-06-09
Release date:2016-09-21
Last modified:2017-12-20
Method:SOLUTION NMR
Cite:Structural basis for KCNE3 modulation of potassium recycling in epithelia.
Sci Adv, 2, 2016
5KDL
  • Download 5kdl
  • View 5kdl
Molmil generated image of 5kdl
CRYSTAL STRUCTURE OF THE 4 ALANINE INSERTION VARIANT OF THE GI ALPHA1 SUBUNIT BOUND TO GTPGAMMAS
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, MAGNESIUM ION, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE
Authors:Kaya, A.I., Lokits, A.D., Gilbert, J., Iverson, T.M., Meiler, J., Hamm, H.E.
Deposit date:2016-06-08
Release date:2016-08-03
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.665 Å)
Cite:A Conserved Hydrophobic Core in G alpha i1 Regulates G Protein Activation and Release from Activated Receptor.
J.Biol.Chem., 291, 2016
5KDO
  • Download 5kdo
  • View 5kdo
Molmil generated image of 5kdo
HETEROTRIMERIC COMPLEX OF THE 4 ALANINE INSERTION VARIANT OF THE GI ALPHA1 SUBUNIT AND THE GBETA1-GGAMMA1
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(T) subunit gamma-T1, ...
Authors:Kaya, A.I., Lokits, A.D., Gilbert, J., Iverson, T.M., Meiler, J., Hamm, H.E.
Deposit date:2016-06-08
Release date:2016-08-03
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A Conserved Hydrophobic Core in G alpha i1 Regulates G Protein Activation and Release from Activated Receptor.
J.Biol.Chem., 291, 2016
5JRP
  • Download 5jrp
  • View 5jrp
Molmil generated image of 5jrp
CRYSTAL STRUCTURE OF MONOCLONAL ANTIBODY MR78 FAB
Descriptor:marberg virus monoclonal antibody MR78 Fab light chain, marberg virus monoclonal antibody MR78 Fab heavy chain, SODIUM ION
Authors:Dong, J., Crowe, J.
Deposit date:2016-05-06
Release date:2017-11-08
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Role of Non-local Interactions between CDR Loops in Binding Affinity of MR78 Antibody to Marburg Virus Glycoprotein.
Structure, 25, 2017
5J3D
  • Download 5j3d
  • View 5j3d
Molmil generated image of 5j3d
CRYSTAL STRUCTURE OF HUMAN FAB 14N4 IN COMPLEX WITH POST-FUSION RSV F
Descriptor:14N4 heavy chain, 14N4 light chain, Fusion glycoprotein F0
Authors:Mousa, J.J., Crowe, J.E.
Deposit date:2016-03-30
Release date:2016-10-26
Last modified:2016-11-23
Method:X-RAY DIFFRACTION (4.077 Å)
Cite:Structural basis for nonneutralizing antibody competition at antigenic site II of the respiratory syncytial virus fusion protein.
Proc.Natl.Acad.Sci.USA, 113, 2016
5ITB
  • Download 5itb
  • View 5itb
Molmil generated image of 5itb
CRYSTAL STRUCTURE OF THE ANTI-RSV F FAB 14N4
Descriptor:anti-RSV F Fab 14N4 Heavy chain, anti-RSV F Fab 14N4 Light chain
Authors:Mousa, J.J., Crowe, J.E.
Deposit date:2016-03-16
Release date:2016-10-26
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for nonneutralizing antibody competition at antigenic site II of the respiratory syncytial virus fusion protein.
Proc.Natl.Acad.Sci.USA, 113, 2016
5BOP
  • Download 5bop
  • View 5bop
Molmil generated image of 5bop
CRYSTAL STRUCTURE OF THE ARTIFICIAL NANOBODY OCTARELLINV.1 COMPLEX
Descriptor:Nanobody, Octarellin V.1
Authors:Figueroa, M., Sleutel, M., Pardon, E., Steyaert, J., Martial, J.A., van de Weerdt, C.
Deposit date:2015-05-27
Release date:2016-05-25
Last modified:2016-06-08
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The unexpected structure of the designed protein Octarellin V.1 forms a challenge for protein structure prediction tools.
J.Struct.Biol., 195, 2016
4ZWQ
  • Download 4zwq
  • View 4zwq
Molmil generated image of 4zwq
CRYSTAL STRUCTURE OF THE BACTERIOPHAGE T4 RECOMBINATION MEDIATOR PROTEIN UVSY, LATTICE TYPE I
Descriptor:Recombination protein uvsY
Authors:Gajewski, S., White, S.W.
Deposit date:2015-05-19
Release date:2016-03-02
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.351 Å)
Cite:Structure and mechanism of the phage T4 recombination mediator protein UvsY.
Proc.Natl.Acad.Sci.USA, 113, 2016
4ZWR
  • Download 4zwr
  • View 4zwr
Molmil generated image of 4zwr
CRYSTAL STRUCTURE OF THE BACTERIOPHAGE T4 RECOMBINATION MEDIATOR PROTEIN UVSY, LATTICE TYPE II
Descriptor:Recombination protein uvsY
Authors:Gajewski, S., White, S.W.
Deposit date:2015-05-19
Release date:2016-03-02
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (3.3857 Å)
Cite:Structure and mechanism of the phage T4 recombination mediator protein UvsY.
Proc.Natl.Acad.Sci.USA, 113, 2016
4ZWS
  • Download 4zws
  • View 4zws
Molmil generated image of 4zws
CRYSTAL STRUCTURE OF THE BACTERIOPHAGE T4 RECOMBINATION MEDIATOR PROTEIN UVSY, LATTICE TYPE III
Descriptor:Recombination protein uvsY
Authors:Gajewski, S., White, S.W.
Deposit date:2015-05-19
Release date:2016-03-02
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure and mechanism of the phage T4 recombination mediator protein UvsY.
Proc.Natl.Acad.Sci.USA, 113, 2016
4ZWT
  • Download 4zwt
  • View 4zwt
Molmil generated image of 4zwt
CRYSTAL STRUCTURE OF THE BACTERIOPHAGE T4 RECOMBINATION MEDIATOR PROTEIN UVSY, LATTICE TYPE IV
Descriptor:Recombination protein uvsY
Authors:Gajewski, S., White, S.W.
Deposit date:2015-05-19
Release date:2016-03-02
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (4.2 Å)
Cite:Structure and mechanism of the phage T4 recombination mediator protein UvsY.
Proc.Natl.Acad.Sci.USA, 113, 2016
4ZV6
  • Download 4zv6
  • View 4zv6
Molmil generated image of 4zv6
CRYSTAL STRUCTURE OF THE ARTIFICIAL ALPHAREP-7 OCTARELLINV.1 COMPLEX
Descriptor:AlphaRep-7, Octarellin V.1
Authors:Figueroa, M., Sleutel, M., Urvoas, A., Valerio-Lepiniec, M., Minard, P., Martial, J.A., van de Weerdt, C.
Deposit date:2015-05-18
Release date:2016-05-25
Last modified:2016-06-08
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:The unexpected structure of the designed protein Octarellin V.1 forms a challenge for protein structure prediction tools.
J.Struct.Biol., 195, 2016
4YAQ
  • Download 4yaq
  • View 4yaq
Molmil generated image of 4yaq
CRYSTAL STRUCTURE OF A COMPUTATIONALLY OPTIMIZED PG9 MUTANT
Descriptor:PG9_N100FY Fab heavy chain, PG9_N100FY Light Chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ...
Authors:Murrell, S., Julien, J.P., Wilson, I.A.
Deposit date:2015-02-17
Release date:2015-06-03
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Redesigned HIV antibodies exhibit enhanced neutralizing potency and breadth.
J.Clin.Invest., 125, 2015
4PAM
  • Download 4pam
  • View 4pam
Molmil generated image of 4pam
A CONSERVED PHENYLALANINE AS RELAY BETWEEN THE 5 HELIX AND THE GDP BINDING REGION OF HETEROTRIMERIC G PROTEIN
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, GUANOSINE-5'-DIPHOSPHATE, SULFITE ION, ...
Authors:Kaya, A.I., Lokits, A.D., Gilbert, J., Iverson, T.M., Meiler, J., Hamm, H.E.
Deposit date:2014-04-09
Release date:2014-07-30
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.101 Å)
Cite:A Conserved Phenylalanine as a Relay between the alpha 5 Helix and the GDP Binding Region of Heterotrimeric Gi Protein alpha Subunit.
J.Biol.Chem., 289, 2014
<12>