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2V64
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BU of 2v64 by Molmil
Crystallographic structure of the conformational dimer of the Spindle Assembly Checkpoint protein Mad2.
Descriptor: MBP1, MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2A
Authors:Mapelli, M, Massimiliano, L, Santaguida, S, Musacchio, A.
Deposit date:2007-07-13
Release date:2007-11-27
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The MAD2 Conformational Dimer: Structure and Implications for the Spindle Assembly Checkpoint
Cell(Cambridge,Mass.), 131, 2007
1UNG
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BU of 1ung by Molmil
Structural mechanism for the inhibition of CDK5-p25 by roscovitine, aloisine and indirubin.
Descriptor: 6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE, CELL DIVISION PROTEIN KINASE 5, CYCLIN-DEPENDENT KINASE 5 ACTIVATOR 1
Authors:Mapelli, M, Crovace, C, Massimiliano, L, Musacchio, A.
Deposit date:2003-09-10
Release date:2004-11-10
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Mechanism of Cdk5/P25 Binding by Cdk Inhibitors
J.Med.Chem., 48, 2005
1UNL
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BU of 1unl by Molmil
Structural mechanism for the inhibition of CD5-p25 from the roscovitine, aloisine and indirubin.
Descriptor: CYCLIN-DEPENDENT KINASE 5, CYCLIN-DEPENDENT KINASE 5 ACTIVATOR 1, R-ROSCOVITINE
Authors:Mapelli, M, Crovace, C, Massimiliano, L, Musacchio, A.
Deposit date:2003-09-10
Release date:2004-11-10
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Mechanism of Cdk5/P25 Binding by Cdk Inhibitors
J.Med.Chem., 48, 2005
1UNH
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BU of 1unh by Molmil
Structural mechanism for the inhibition of CDK5-p25 by roscovitine, aloisine and indirubin.
Descriptor: (Z)-1H,1'H-[2,3']BIINDOLYLIDENE-3,2'-DIONE-3-OXIME, CYCLIN-DEPENDENT KINASE 5, CYCLIN-DEPENDENT KINASE 5 ACTIVATOR 1
Authors:Mapelli, M, Crovace, C, Massimiliano, L, Musacchio, A.
Deposit date:2003-09-10
Release date:2004-11-10
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Mechanism of Cdk5/P25 Binding by Cdk Inhibitors
J.Med.Chem., 48, 2005
5NJK
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BU of 5njk by Molmil
PTB domain of human Numb isoform-1
Descriptor: ALA-TYR-ILE-GLY-PRO-PTR-LEU, Protein numb homolog, SULFATE ION
Authors:Mapelli, M, Di Fiore, P.P.
Deposit date:2017-03-29
Release date:2017-12-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.13 Å)
Cite:A Numb-Mdm2 fuzzy complex reveals an isoform-specific involvement of Numb in breast cancer.
J. Cell Biol., 217, 2018
5NJJ
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BU of 5njj by Molmil
PTB domain of human Numb isoform-1
Descriptor: ALA-TYR-ILE-GLY-PRO-PTR-LEU, Protein numb homolog, SULFATE ION
Authors:Mapelli, M, Di Fiore, P.P.
Deposit date:2017-03-29
Release date:2017-12-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A Numb-Mdm2 fuzzy complex reveals an isoform-specific involvement of Numb in breast cancer.
J. Cell Biol., 217, 2018
3O0G
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BU of 3o0g by Molmil
Crystal Structure of Cdk5:p25 in complex with an ATP analogue
Descriptor: Cell division protein kinase 5, Cyclin-dependent kinase 5 activator 1, {4-amino-2-[(4-chlorophenyl)amino]-1,3-thiazol-5-yl}(3-nitrophenyl)methanone
Authors:Mapelli, M.
Deposit date:2010-07-19
Release date:2011-01-26
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Defining Cdk5 ligand chemical space with small molecule inhibitors of Tau phosphorylation
Chem.Biol., 12, 2005
1URJ
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BU of 1urj by Molmil
Single stranded DNA-binding protein(ICP8) from Herpes simplex virus-1
Descriptor: MAJOR DNA-BINDING PROTEIN, MERCURY (II) ION, ZINC ION
Authors:Panjikar, S, Mapelli, M, Tucker, P.A.
Deposit date:2003-10-30
Release date:2004-11-11
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (3 Å)
Cite:The crystal structure of the herpes simplex virus 1 ssDNA-binding protein suggests the structural basis for flexible, cooperative single-stranded DNA binding.
J. Biol. Chem., 280, 2005
6QJA
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BU of 6qja by Molmil
Organizational principles of the NuMA-Dynein interaction interface and implications for mitotic spindle functions
Descriptor: CHLORIDE ION, MAGNESIUM ION, Nuclear mitotic apparatus protein 1
Authors:Renna, C, Rizzelli, F, Carminati, M, Gaddoni, C, Pirovano, L, Cecatiello, V, Pasqualato, S, Mapelli, M.
Deposit date:2019-01-23
Release date:2020-02-05
Last modified:2020-07-15
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Organizational Principles of the NuMA-Dynein Interaction Interface and Implications for Mitotic Spindle Functions.
Structure, 28, 2020
6HC2
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BU of 6hc2 by Molmil
Crystal structure of NuMA/LGN hetero-hexamers
Descriptor: G-protein-signaling modulator 2, Nuclear mitotic apparatus protein 1
Authors:Pasqualato, S, Culurgioni, S, Foadi, J, Alfieri, A, Mapelli, M.
Deposit date:2018-08-13
Release date:2019-05-29
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (4.31 Å)
Cite:Hexameric NuMA:LGN structures promote multivalent interactions required for planar epithelial divisions.
Nat Commun, 10, 2019
4A7J
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BU of 4a7j by Molmil
Symmetric Dimethylation of H3 Arginine 2 is a Novel Histone Mark that Supports Euchromatin Maintenance
Descriptor: HISTONE H3.1T, WD REPEAT-CONTAINING PROTEIN 5
Authors:Migliori, V, Muller, J, Phalke, S, Low, D, Bezzi, M, ChuenMok, W, Gunaratne, J, Capasso, P, Bassi, C, Cecatiello, V, DeMarco, A, Blackstock, W, Kuznetsov, V, Amati, B, Mapelli, M, Guccione, E.
Deposit date:2011-11-14
Release date:2012-01-11
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Symmetric Dimethylation of H3R2 is a Newly Identified Histone Mark that Supports Euchromatin Maintenance
Nat.Struct.Mol.Biol., 19, 2012
4A1S
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BU of 4a1s by Molmil
Crystallographic structure of the Pins:Insc complex
Descriptor: PARTNER OF INSCUTEABLE, RE60102P
Authors:Culurgioni, S, Alfieri, A, Pendolino, V, Laddomada, F, Mapelli, M.
Deposit date:2011-09-19
Release date:2012-03-28
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Inscuteable and Numa Proteins Bind Competitively to Leu-Gly- Asn Repeat-Enriched Protein (Lgn) During Asymmetric Cell Divisions.
Proc.Natl.Acad.Sci.USA, 108, 2011
5A7D
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BU of 5a7d by Molmil
Tetrameric assembly of LGN with Inscuteable
Descriptor: INSCUTEABLE, PINS
Authors:Culurgioni, S, Mari, S, Bonetto, G, Gallini, S, Brennich, M, Round, A, Mapelli, M.
Deposit date:2015-07-07
Release date:2016-08-03
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:The Structure of the Insc:Lgn Tetramer Reveals a New Function of Lgn in Promoting Asymmetric Cell Divisions
To be Published
5A6C
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BU of 5a6c by Molmil
Concomitant binding of Afadin to LGN and F-actin directs planar spindle orientation
Descriptor: G-PROTEIN-SIGNALING MODULATOR 2, AFADIN, SULFATE ION
Authors:Carminati, M, Gallini, S, Pirovano, L, Alfieri, A, Bisi, S, Mapelli, M.
Deposit date:2015-06-25
Release date:2015-12-30
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.901 Å)
Cite:Concomitant Binding of Afadin to Lgn and F-Actin Directs Planar Spindle Orientation.
Nat.Struct.Mol.Biol., 23, 2016
6ZT0
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BU of 6zt0 by Molmil
Crystal structure of the Eiger TNF domain/Grindelwald extracellular domain complex
Descriptor: 1,2-ETHANEDIOL, Protein eiger, Protein grindelwald
Authors:Palmerini, V, Cecatiello, V, Pasqualato, S, Mapelli, M.
Deposit date:2020-07-17
Release date:2021-03-03
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Drosophila TNFRs Grindelwald and Wengen bind Eiger with different affinities and promote distinct cellular functions.
Nat Commun, 12, 2021
6ZSZ
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BU of 6zsz by Molmil
Crystal structure of the Grindelwald extracellular domain complex
Descriptor: Protein grindelwald
Authors:Palmerini, V, Cecatiello, V, Pasqualato, S, Mapelli, M.
Deposit date:2020-07-17
Release date:2021-03-31
Last modified:2021-10-13
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Drosophila TNFRs Grindelwald and Wengen bind Eiger with different affinities and promote distinct cellular functions.
Nat Commun, 12, 2021
6ZSY
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BU of 6zsy by Molmil
Crystal structure of the Grindelwald extracellular domain complex
Descriptor: Protein grindelwald
Authors:Palmerini, V, Cecatiello, V, Pasqualato, S, Mapelli, M.
Deposit date:2020-07-17
Release date:2021-03-31
Last modified:2021-10-13
Method:X-RAY DIFFRACTION (0.926 Å)
Cite:Drosophila TNFRs Grindelwald and Wengen bind Eiger with different affinities and promote distinct cellular functions.
Nat Commun, 12, 2021
1GO4
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BU of 1go4 by Molmil
Crystal structure of Mad1-Mad2 reveals a conserved Mad2 binding motif in Mad1 and Cdc20.
Descriptor: Mitotic spindle assembly checkpoint protein MAD1, Mitotic spindle assembly checkpoint protein MAD2A
Authors:Sironi, L, Mapelli, M, Jeang, K.T, Musacchio, A.
Deposit date:2001-10-17
Release date:2002-05-16
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpoint.
EMBO J., 21, 2002
2BFY
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BU of 2bfy by Molmil
Complex of Aurora-B with INCENP and Hesperadin.
Descriptor: AURORA KINASE B-A, INNER CENTROMERE PROTEIN A, N-[2-OXO-3-((E)-PHENYL{[4-(PIPERIDIN-1-YLMETHYL)PHENYL]IMINO}METHYL)-2,6-DIHYDRO-1H-INDOL-5-YL]ETHANESULFONAMIDE
Authors:Sessa, F, Mapelli, M, Ciferri, C, Tarricone, C, Areces, L.B, Schneider, T.R, Stukenberg, P.T, Musacchio, A.
Deposit date:2004-12-15
Release date:2005-05-03
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Mechanism of Aurora B Activation by Incenp and Inhibition by Hesperadin
Mol.Cell, 18, 2005
2BFX
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BU of 2bfx by Molmil
Mechanism of Aurora-B activation by INCENP and inhibition by Hesperadin.
Descriptor: AURORA KINASE B-A, INNER CENTROMERE PROTEIN A
Authors:Sessa, F, Mapelli, M, Ciferri, C, Tarricone, C, Areces, L.B, Schneider, T.R, Stukenberg, P.T, Musacchio, A.
Deposit date:2004-12-15
Release date:2005-05-03
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Mechanism of Aurora B Activation by Incenp and Inhibition by Hesperadin
Mol.Cell, 18, 2005
2C7N
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BU of 2c7n by Molmil
Human Rabex-5 residues 1-74 in complex with Ubiquitin
Descriptor: RAB GUANINE NUCLEOTIDE EXCHANGE FACTOR 1, UBIQUITIN, ZINC ION
Authors:Penengo, L, Mapelli, M, Murachelli, A.G, Confalioneri, S, Magri, L, Musacchio, A, Di Fiore, P.P, Polo, S, Schneider, T.R.
Deposit date:2005-11-25
Release date:2006-02-15
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structure of the Ubiquitin Binding Domains of Rabex-5 Reveals Two Modes of Interaction with Ubiquitin.
Cell(Cambridge,Mass.), 124, 2006
2C7M
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BU of 2c7m by Molmil
Human Rabex-5 residues 1-74 in complex with Ubiquitin
Descriptor: RAB GUANINE NUCLEOTIDE EXCHANGE FACTOR 1, UBIQUITIN, ZINC ION
Authors:Penengo, L, Mapelli, M, Murachelli, A.G, Confalioneri, S, Magri, L, Musacchio, A, Di Fiore, P.P, Polo, S, Schneider, T.R.
Deposit date:2005-11-25
Release date:2006-02-15
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of the ubiquitin binding domains of rabex-5 reveals two modes of interaction with ubiquitin.
Cell, 124, 2006
2N12
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BU of 2n12 by Molmil
Solution structure of human Myosin VI isoform3 (1050-1131)
Descriptor: Unconventional myosin-VI
Authors:He, F, Walters, K.
Deposit date:2015-03-20
Release date:2016-03-02
Last modified:2021-11-03
Method:SOLUTION NMR
Cite:Diverse functions of myosin VI elucidated by an isoform-specific alpha-helix domain.
Nat.Struct.Mol.Biol., 23, 2016

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