1UNG

Structural mechanism for the inhibition of CDK5-p25 by roscovitine, aloisine and indirubin.

Summary for 1UNG

Entry DOI	10.2210/pdb1ung/pdb
Related	1H4L 1LFR 1UNH 1UNL
Descriptor	CELL DIVISION PROTEIN KINASE 5, CYCLIN-DEPENDENT KINASE 5 ACTIVATOR 1, 6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE, ... (4 entities in total)
Functional Keywords	cell cycle, complex(kinase-activator), inhibitors, neurodegenerative diseases
Biological source	HOMO SAPIENS (HUMAN) More
Cellular location	Cytoplasm (By similarity): Q00535 Cyclin-dependent kinase 5 activator 1, p35: Cell membrane; Lipid-anchor; Cytoplasmic side (Probable). Cyclin-dependent kinase 5 activator 1, p25: Nucleus: Q15078
Total number of polymer chains	4
Total formula weight	113634.96
Authors	Mapelli, M.,Crovace, C.,Massimiliano, L.,Musacchio, A. (deposition date: 2003-09-10, release date: 2004-11-10, Last modification date: 2023-12-13)
Primary citation	Mapelli, M.,Massimilinao, L.,Crovace, C.,Seeliger, M.A.,Tsai, L.-H.,Meijer, L.,Musacchio, A. Mechanism of Cdk5/P25 Binding by Cdk Inhibitors J.Med.Chem., 48:671-, 2005 Cited by PubMed: 15689152 DOI: 10.1021/JM049323M PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation