1UNG
Structural mechanism for the inhibition of CDK5-p25 by roscovitine, aloisine and indirubin.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | CELL DIVISION PROTEIN KINASE 5 | polymer | 292 | 33349.5 | 2 | UniProt (Q00535) Pfam (PF00069) | HOMO SAPIENS (HUMAN) | TAU PROTEIN KINASE II, TPKII CATALYTIC, SERINE/THREONINE PROTEIN KINASE PSSALRE, CYCLIN-DEPENDENT KINASE 5 |
| 2 | C, D (D, E) | CYCLIN-DEPENDENT KINASE 5 ACTIVATOR 1 | polymer | 208 | 23200.7 | 2 | UniProt (Q15078) Pfam (PF03261) | HOMO SAPIENS (HUMAN) | CDK5 ACTIVATOR 1, CYCLIN-DEPENDENT KINASE 5 REGULATORY SUBUNIT 1, TAU PROTEIN KINASE II, TPKII REGULATORY SUBUNIT, P23, P25, P35NCK5A |
| 3 | E, F (A, B) | 6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE | non-polymer | 267.3 | 2 | Chemie (ALH) | |||
| 4 | G, H, I, J (A, B, D, E) | water | water | 18.0 | 294 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 292 (UniProt: Q00535)
| PDB | External Database | Details |
|---|---|---|
| Asn 144 | Asp 144 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 113100.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 534.7 | |
| All* | Total formula weight | 113635.0 |
