Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

1UNH

Structural mechanism for the inhibition of CDK5-p25 by roscovitine, aloisine and indirubin.

Summary for 1UNH
Entry DOI10.2210/pdb1unh/pdb
Related1H4L 1LFR 1UNG 1UNL
DescriptorCYCLIN-DEPENDENT KINASE 5, CYCLIN-DEPENDENT KINASE 5 ACTIVATOR 1, (Z)-1H,1'H-[2,3']BIINDOLYLIDENE-3,2'-DIONE-3-OXIME, ... (4 entities in total)
Functional Keywordscell cycle, neurodegenerative diseases, indirubin
Biological sourceHOMO SAPIENS (HUMAN)
More
Cellular locationCytoplasm (By similarity): Q00535
Cyclin-dependent kinase 5 activator 1, p35: Cell membrane; Lipid-anchor; Cytoplasmic side (Probable). Cyclin-dependent kinase 5 activator 1, p25: Nucleus: Q15078
Total number of polymer chains4
Total formula weight113654.86
Authors
Mapelli, M.,Crovace, C.,Massimiliano, L.,Musacchio, A. (deposition date: 2003-09-10, release date: 2004-11-10, Last modification date: 2023-12-13)
Primary citationMapelli, M.,Massimilinao, L.,Crovace, C.,Seeliger, M.A.,Tsai, L.-H.,Meijer, L.,Musacchio, A.
Mechanism of Cdk5/P25 Binding by Cdk Inhibitors
J.Med.Chem., 48:671-, 2005
Cited by
PubMed: 15689152
DOI: 10.1021/JM049323M
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.35 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon