1UNG
Structural mechanism for the inhibition of CDK5-p25 by roscovitine, aloisine and indirubin.
Summary for 1UNG
Entry DOI | 10.2210/pdb1ung/pdb |
Related | 1H4L 1LFR 1UNH 1UNL |
Descriptor | CELL DIVISION PROTEIN KINASE 5, CYCLIN-DEPENDENT KINASE 5 ACTIVATOR 1, 6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE, ... (4 entities in total) |
Functional Keywords | cell cycle, complex(kinase-activator), inhibitors, neurodegenerative diseases |
Biological source | HOMO SAPIENS (HUMAN) More |
Cellular location | Cytoplasm (By similarity): Q00535 Cyclin-dependent kinase 5 activator 1, p35: Cell membrane; Lipid-anchor; Cytoplasmic side (Probable). Cyclin-dependent kinase 5 activator 1, p25: Nucleus: Q15078 |
Total number of polymer chains | 4 |
Total formula weight | 113634.96 |
Authors | Mapelli, M.,Crovace, C.,Massimiliano, L.,Musacchio, A. (deposition date: 2003-09-10, release date: 2004-11-10, Last modification date: 2023-12-13) |
Primary citation | Mapelli, M.,Massimilinao, L.,Crovace, C.,Seeliger, M.A.,Tsai, L.-H.,Meijer, L.,Musacchio, A. Mechanism of Cdk5/P25 Binding by Cdk Inhibitors J.Med.Chem., 48:671-, 2005 Cited by PubMed: 15689152DOI: 10.1021/JM049323M PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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