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8BW8
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BU of 8bw8 by Molmil
Crystal structure of the dCNK-SAM-CRIC-PDZ/dHYP-SAM complex
Descriptor: Connector enhancer of KSR protein CNK, GLYCEROL, Protein aveugle
Authors:Maisonneuve, P, Kurinov, I, Sicheri, F.
Deposit date:2022-12-06
Release date:2024-02-21
Last modified:2024-07-31
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The CNK-HYP scaffolding complex promotes RAF activation by enhancing KSR-MEK interaction.
Nat.Struct.Mol.Biol., 31, 2024
8BW9
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BU of 8bw9 by Molmil
Cryo-EM structure of the RAF activating complex KSR-MEK-CNK-HYP
Descriptor: Connector enhancer of KSR protein CNK, Dual specificity mitogen-activated protein kinase kinase dSOR1, KSR, ...
Authors:Maisonneuve, P, Fronzes, R, Sicheri, F.
Deposit date:2022-12-06
Release date:2024-02-21
Last modified:2024-07-31
Method:ELECTRON MICROSCOPY (3.32 Å)
Cite:The CNK-HYP scaffolding complex promotes RAF activation by enhancing KSR-MEK interaction.
Nat.Struct.Mol.Biol., 31, 2024
5EYZ
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BU of 5eyz by Molmil
CRYSTAL STRUCTURE OF THE PTPN4 PDZ DOMAIN COMPLEXED WITH THE TAILORED PEPTIDE CYTO8-RETEV
Descriptor: CHLORIDE ION, CYTO8-RETEV, Tyrosine-protein phosphatase non-receptor type 4
Authors:Maisonneuve, P, Vaney, M.C, Babault, B, Caillet-Saguy, C, Lafon, M, Delepierre, M, Cordier, F, Wolff, N.
Deposit date:2015-11-26
Release date:2016-06-08
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Molecular Basis of the Interaction of the Human Protein Tyrosine Phosphatase Non-receptor Type 4 (PTPN4) with the Mitogen-activated Protein Kinase p38 gamma.
J.Biol.Chem., 291, 2016
5EZ0
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BU of 5ez0 by Molmil
CRYSTAL STRUCTURE OF THE PTPN4 PDZ DOMAIN COMPLEXED WITH THE PDZ BINDING MOTIF OF THE MITOGEN ACTIVATED PROTEIN KINASE P38GAMMA.
Descriptor: Mitogen-activated protein kinase 12, SULFATE ION, Tyrosine-protein phosphatase non-receptor type 4
Authors:Maisonneuve, P, Vaney, M.C, Caillet-Saguy, C, Lafon, M, Delepierre, M, Cordier, F, Wolff, N.
Deposit date:2015-11-26
Release date:2016-06-08
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Molecular Basis of the Interaction of the Human Protein Tyrosine Phosphatase Non-receptor Type 4 (PTPN4) with the Mitogen-activated Protein Kinase p38 gamma.
J.Biol.Chem., 291, 2016
6UUO
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BU of 6uuo by Molmil
Crystal structure of BRAF kinase domain bound to the PROTAC P4B
Descriptor: N-(3-{5-[(1-acetylpiperidin-4-yl)(methyl)amino]-3-(pyrimidin-5-yl)-1H-pyrrolo[3,2-b]pyridin-1-yl}-2,4-difluorophenyl)propane-1-sulfonamide, Serine/threonine-protein kinase B-raf
Authors:Maisonneuve, P, Posternak, G, Kurinov, I, Sicheri, F.
Deposit date:2019-10-30
Release date:2020-06-03
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.288 Å)
Cite:Functional characterization of a PROTAC directed against BRAF mutant V600E.
Nat.Chem.Biol., 16, 2020
6NTD
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BU of 6ntd by Molmil
Crystal Structure of G12V HRas-GppNHp bound in complex with the engineered RBD variant 12 of CRAF Kinase protein
Descriptor: GTPase HRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
Authors:Maisonneuve, P, Kurinov, I, Wiechmann, S, Ernst, A, Sicheri, F.
Deposit date:2019-01-28
Release date:2020-03-04
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Conformation-specific inhibitors of activated Ras GTPases reveal limited Ras dependency of patient-derived cancer organoids.
J.Biol.Chem., 295, 2020
5VYK
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BU of 5vyk by Molmil
Crystal structure of the BRS domain of BRAF in complex with the CC-SAM domain of KSR1
Descriptor: Chimera protein of BRS domain of BRAF and CC-SAM domain of KSR1,Serine/threonine-protein kinase B-raf, GLYCEROL
Authors:Maisonneuve, P, Kurinov, I, Marullo, S.A, Lavoie, H, Thevakumaran, N, Sahmi, M, Jin, T, Therrien, M, SIcheri, F.
Deposit date:2017-05-25
Release date:2018-02-14
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.749 Å)
Cite:MEK drives BRAF activation through allosteric control of KSR proteins.
Nature, 554, 2018
6NSQ
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BU of 6nsq by Molmil
Crystal structure of BRAF kinase domain bound to the inhibitor 2l
Descriptor: 5-[(4-amino-1-ethyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)ethynyl]-N-(4-chlorophenyl)-6-methylisoquinolin-1-amine, Serine/threonine-protein kinase B-raf
Authors:Maisonneuve, P, Kurinov, I, Assadieskandar, A, Yu, C, Zhang, C, Sicheri, F.
Deposit date:2019-01-25
Release date:2019-06-19
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Rigidification Dramatically Improves Inhibitor Selectivity for RAF Kinases.
Acs Med.Chem.Lett., 10, 2019
6NTC
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BU of 6ntc by Molmil
Crystal Structure of G12V HRas-GppNHp bound in complex with the engineered RBD variant 1 of CRAF Kinase protein
Descriptor: GLYCEROL, GTPase HRas, MAGNESIUM ION, ...
Authors:Maisonneuve, P, Kurinov, I, Wiechmann, S, Ernst, A, Sicheri, F.
Deposit date:2019-01-28
Release date:2020-03-04
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Conformation-specific inhibitors of activated Ras GTPases reveal limited Ras dependency of patient-derived cancer organoids.
J.Biol.Chem., 295, 2020
6CAD
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BU of 6cad by Molmil
Crystal structure of RAF kinase domain bound to the inhibitor 2a
Descriptor: 1-(propan-2-yl)-3-({3-[3-(trifluoromethyl)phenyl]isoquinolin-8-yl}ethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Serine/threonine-protein kinase B-raf
Authors:Maisonneuve, P, Kurinov, I, Assadieskandar, A, Yu, C, Liu, X, Chen, Y.-C, Prakash, G.K.S, Zhang, C, SIcheri, F.
Deposit date:2018-01-30
Release date:2018-02-21
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Effects of rigidity on the selectivity of protein kinase inhibitors.
Eur J Med Chem, 146, 2018
5VR3
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BU of 5vr3 by Molmil
Crystal structure of the BRS domain of BRAF
Descriptor: BRAF, SULFATE ION
Authors:Thevakumaran, N, Maisonneuve, P, Kurinov, I, Lavoie, H, Marullo, S.A, Sahmi, M, Jin, T, Therrien, M, Sicheri, F.
Deposit date:2017-05-10
Release date:2018-02-14
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.102 Å)
Cite:MEK drives BRAF activation through allosteric control of KSR proteins.
Nature, 554, 2018
7KJT
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BU of 7kjt by Molmil
KEOPS tRNA modifying sub-complex of archaeal Cgi121 and tRNA
Descriptor: RNA (70-MER), Regulatory protein Cgi121
Authors:Ceccarelli, D.F, Beenstock, J, Mao, D.Y.L, Sicheri, F.
Deposit date:2020-10-26
Release date:2020-12-02
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.34 Å)
Cite:A substrate binding model for the KEOPS tRNA modifying complex.
Nat Commun, 11, 2020
7KJU
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BU of 7kju by Molmil
Cgi121-tRNA complex
Descriptor: MAGNESIUM ION, RNA (75-MER)
Authors:Ceccarelli, D.F, Beenstock, J, Wan, L.C.K, Sicheri, F.
Deposit date:2020-10-26
Release date:2020-12-02
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.102 Å)
Cite:A substrate binding model for the KEOPS tRNA modifying complex.
Nat Commun, 11, 2020
6DRM
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BU of 6drm by Molmil
OTU domain of Fam105A
Descriptor: Inactive ubiquitin thioesterase FAM105A
Authors:Ceccarelli, D.F, Sicheri, F, Cordes, S.
Deposit date:2018-06-12
Release date:2019-05-08
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane.
Structure, 27, 2019
7U3E
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BU of 7u3e by Molmil
GID4 in complex with compound 1
Descriptor: Glucose-induced degradation protein 4 homolog, tert-butyl (1S,4S)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate
Authors:Chana, C.K, Sicheri, F.
Deposit date:2022-02-27
Release date:2022-10-05
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.852 Å)
Cite:Discovery and Structural Characterization of Small Molecule Binders of the Human CTLH E3 Ligase Subunit GID4.
J.Med.Chem., 65, 2022
7U3F
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BU of 7u3f by Molmil
GID4 in complex with compound 4
Descriptor: (4R)-4-(4-methoxyphenyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine, GLYCEROL, Glucose-induced degradation protein 4 homolog
Authors:Chana, C.K, Sicheri, F.
Deposit date:2022-02-27
Release date:2022-10-05
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Discovery and Structural Characterization of Small Molecule Binders of the Human CTLH E3 Ligase Subunit GID4.
J.Med.Chem., 65, 2022
7U3H
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BU of 7u3h by Molmil
GID4 in complex with compound 7
Descriptor: (5R)-N-(4-fluorophenyl)-5-methyl-4,5-dihydro-1,3-thiazol-2-amine, Glucose-induced degradation protein 4 homolog
Authors:Chana, C.K, Sicheri, F.
Deposit date:2022-02-27
Release date:2022-10-05
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.798 Å)
Cite:Discovery and Structural Characterization of Small Molecule Binders of the Human CTLH E3 Ligase Subunit GID4.
J.Med.Chem., 65, 2022
7U3L
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BU of 7u3l by Molmil
GID4 in complex with compound 91
Descriptor: GLYCEROL, Glucose-induced degradation protein 4 homolog, Nalpha-{(2R,4E)-2-[(N-benzylglycyl)amino]-5-phenylpent-4-enoyl}-N,4-dimethyl-L-phenylalaninamide
Authors:Chana, C.K, Sicheri, F.
Deposit date:2022-02-27
Release date:2022-10-05
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.295 Å)
Cite:Discovery and Structural Characterization of Small Molecule Binders of the Human CTLH E3 Ligase Subunit GID4.
J.Med.Chem., 65, 2022
7U3G
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BU of 7u3g by Molmil
GID4 in complex with compound 67
Descriptor: (1R)-1-phenyl-1,2,3,4-tetrahydroisoquinolin-5-amine, Glucose-induced degradation protein 4 homolog
Authors:Chana, C.K, Sicheri, F.
Deposit date:2022-02-27
Release date:2022-10-05
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.244 Å)
Cite:Discovery and Structural Characterization of Small Molecule Binders of the Human CTLH E3 Ligase Subunit GID4.
J.Med.Chem., 65, 2022
7U3K
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BU of 7u3k by Molmil
GID4 in complex with compound 89
Descriptor: GLYCEROL, Glucose-induced degradation protein 4 homolog, N-butylglycyl-4-tert-butyl-D-phenylalanyl-3-methoxy-N-methyl-L-phenylalaninamide
Authors:Chana, C.K, Sicheri, F.
Deposit date:2022-02-27
Release date:2022-10-05
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.198 Å)
Cite:Discovery and Structural Characterization of Small Molecule Binders of the Human CTLH E3 Ligase Subunit GID4.
J.Med.Chem., 65, 2022
7U3I
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BU of 7u3i by Molmil
GID4 in complex with compound 16
Descriptor: 3-{[(5S)-5-methyl-4,5-dihydro-1,3-thiazol-2-yl]amino}phenol, GLYCEROL, Glucose-induced degradation protein 4 homolog
Authors:Chana, C.K, Sicheri, F.
Deposit date:2022-02-27
Release date:2022-10-05
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.991 Å)
Cite:Discovery and Structural Characterization of Small Molecule Binders of the Human CTLH E3 Ligase Subunit GID4.
J.Med.Chem., 65, 2022
7U3J
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BU of 7u3j by Molmil
GID4 in complex with compound 88
Descriptor: (2S)-2-{[(2S)-2-({N-[(2,4-dimethoxyphenyl)methyl]glycyl}amino)-2-(thiophen-2-yl)acetyl]amino}-N-methyl-4-phenylbutanamide, GLYCEROL, Glucose-induced degradation protein 4 homolog
Authors:Chana, C.K, Sicheri, F.
Deposit date:2022-02-27
Release date:2022-10-05
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.642 Å)
Cite:Discovery and Structural Characterization of Small Molecule Binders of the Human CTLH E3 Ligase Subunit GID4.
J.Med.Chem., 65, 2022

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PDB entries from 2024-09-18

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