5VR3
Crystal structure of the BRS domain of BRAF
Summary for 5VR3
Entry DOI | 10.2210/pdb5vr3/pdb |
Descriptor | BRAF, SULFATE ION (3 entities in total) |
Functional Keywords | braf, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 9640.48 |
Authors | Thevakumaran, N.,Maisonneuve, P.,Kurinov, I.,Lavoie, H.,Marullo, S.A.,Sahmi, M.,Jin, T.,Therrien, M.,Sicheri, F. (deposition date: 2017-05-10, release date: 2018-02-14, Last modification date: 2024-03-13) |
Primary citation | Lavoie, H.,Sahmi, M.,Maisonneuve, P.,Marullo, S.A.,Thevakumaran, N.,Jin, T.,Kurinov, I.,Sicheri, F.,Therrien, M. MEK drives BRAF activation through allosteric control of KSR proteins. Nature, 554:549-553, 2018 Cited by PubMed: 29433126DOI: 10.1038/nature25478 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.102 Å) |
Structure validation
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