5EZ0

CRYSTAL STRUCTURE OF THE PTPN4 PDZ DOMAIN COMPLEXED WITH THE PDZ BINDING MOTIF OF THE MITOGEN ACTIVATED PROTEIN KINASE P38GAMMA.

Summary for 5EZ0

• Entry DOI: 10.2210/pdb5ez0/pdb
• Related: 3NFK 3NFL 5EYZ
• Descriptor: Tyrosine-protein phosphatase non-receptor type 4, Mitogen-activated protein kinase 12, SULFATE ION, ... (4 entities in total)
• Functional Keywords: apoptosis, cell death, glioblastoma, multiprotein complexes, pdz domains, p38gamma, mitogen activated protein kinase, protein binding, non-receptor type 4, ptpn4, rabies virus, pdz binding motif
• Biological source: Homo sapiens (Human); More
• Cellular location: Cell membrane ; Peripheral membrane protein ; Cytoplasmic side : P29074
• Total number of polymer chains: 8
• Total formula weight: 52071.39

Authors

Maisonneuve, P.,Vaney, M.C.,Caillet-Saguy, C.,Lafon, M.,Delepierre, M.,Cordier, F.,Wolff, N. (deposition date: 2015-11-26, release date: 2016-06-08, Last modification date: 2024-01-10)

• Primary citation: Maisonneuve, P.,Caillet-Saguy, C.,Vaney, M.C.,Bibi-Zainab, E.,Sawyer, K.,Raynal, B.,Haouz, A.,Delepierre, M.,Lafon, M.,Cordier, F.,Wolff, N.; Molecular Basis of the Interaction of the Human Protein Tyrosine Phosphatase Non-receptor Type 4 (PTPN4) with the Mitogen-activated Protein Kinase p38 gamma.; J.Biol.Chem., 291:16699-16708, 2016; PubMed: 27246854; DOI: 10.1074/jbc.M115.707208

Experimental method

X-RAY DIFFRACTION (2.35 Å)