5EZ0

CRYSTAL STRUCTURE OF THE PTPN4 PDZ DOMAIN COMPLEXED WITH THE PDZ BINDING MOTIF OF THE MITOGEN ACTIVATED PROTEIN KINASE P38GAMMA.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Tyrosine-protein phosphatase non-receptor type 4	polymer	107	11694.4	4	UniProt (P29074) Pfam (PF00595) In PDB	Homo sapiens (Human)	Protein-tyrosine phosphatase MEG1,PTPase-MEG1
2	E, F, G, H	Mitogen-activated protein kinase 12	polymer	11	1275.5	4	UniProt (B5MDL5) In PDB	Homo sapiens	Mitogen-activated protein kinase 12,isoform CRA_a
3	D, G	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
4		water	water		18.0	95	Chemie (HOH)

Sequence modifications

A, B, C, D: 499 - 604 (UniProt: P29074)

PDB	External Database	Details
Gly 498	-	expression tag

E, F, G, H: 5 - 13 (UniProt: B5MDL5)

PDB	External Database	Details
Ser 3	-	expression tag
Trp 4	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	51879.3
Non-Polymers*	Number of molecules	2
	Total formula weight	192.1
All*	Total formula weight	52071.4

*Water molecules are not included.