6UUO

Crystal structure of BRAF kinase domain bound to the PROTAC P4B

Summary for 6UUO

Entry DOI	10.2210/pdb6uuo/pdb
Descriptor	Serine/threonine-protein kinase B-raf, N-(3-{5-[(1-acetylpiperidin-4-yl)(methyl)amino]-3-(pyrimidin-5-yl)-1H-pyrrolo[3,2-b]pyridin-1-yl}-2,4-difluorophenyl)propane-1-sulfonamide (3 entities in total)
Functional Keywords	complex, protac, signaling, signaling protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	65667.19
Authors	Maisonneuve, P.,Posternak, G.,Kurinov, I.,Sicheri, F. (deposition date: 2019-10-30, release date: 2020-06-03, Last modification date: 2023-10-11)
Primary citation	Posternak, G.,Tang, X.,Maisonneuve, P.,Jin, T.,Lavoie, H.,Daou, S.,Orlicky, S.,Goullet de Rugy, T.,Caldwell, L.,Chan, K.,Aman, A.,Prakesch, M.,Poda, G.,Mader, P.,Wong, C.,Maier, S.,Kitaygorodsky, J.,Larsen, B.,Colwill, K.,Yin, Z.,Ceccarelli, D.F.,Batey, R.A.,Taipale, M.,Kurinov, I.,Uehling, D.,Wrana, J.,Durocher, D.,Gingras, A.C.,Al-Awar, R.,Therrien, M.,Sicheri, F. Functional characterization of a PROTAC directed against BRAF mutant V600E. Nat.Chem.Biol., 16:1170-1178, 2020 Cited by PubMed: 32778845 DOI: 10.1038/s41589-020-0609-7 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.288 Å)

Structure validation