Author results

6KZ6
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CRYSTAL STRUCTURE OF ASFV DUTPASE
Descriptor:E165R, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, MAGNESIUM ION
Authors:Guo, Y., Chen, C., Li, G.B., Cao, L., Wang, C.W.
Deposit date:2019-09-23
Release date:2019-11-13
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (2.187 Å)
Cite:Structural insight into the African swine fever virus dUTPase reveals a novel folding pattern in the dUTPase family.
J.Virol., 2019
6K1H
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STRUCTURE OF MEMBRANE PROTEIN
Descriptor:PTS system mannose-specific EIID component, PTS mannose/fructose/sorbose transporter subunit IIC, ALPHA-D-MANNOSE
Authors:Wang, J.W., Zeng, J.W.
Deposit date:2019-05-10
Release date:2019-07-10
Last modified:2019-08-14
Method:ELECTRON MICROSCOPY (3.52 Å)
Cite:Structure of the mannose transporter of the bacterial phosphotransferase system.
Cell Res., 29, 2019
6JZA
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STRUCTURE OF FSTL1
Descriptor:Follistatin-related protein 1
Authors:Liu, X., Ning, W.
Deposit date:2019-04-30
Release date:2019-08-21
Last modified:2019-09-25
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural and functional study of FK domain of Fstl1.
Protein Sci., 28, 2019
6RK2
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COMPLEX STRUCTURE OF VIRULENCE FACTOR SGHA MUTANT WITH ITS SUBSTRATE SAG
Descriptor:Beta-glucosidase, 2-(alpha-L-altropyranosyloxy)benzoic acid
Authors:Ye, F.Z., Wang, C., Chang, C.Q., Zhang, L.H., Gao, Y.G.
Deposit date:2019-04-30
Release date:2019-10-09
Last modified:2019-11-06
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Agrobacteria reprogram virulence gene expression by controlled release of host-conjugated signals.
Proc.Natl.Acad.Sci.USA, 116, 2019
6RJO
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COMPLEX STRUCTURE OF VIRULENCE FACTOR SGHA WITH ITS SUBSTRATE ANALOG SALICIN
Descriptor:Beta-glucosidase, 2-(hydroxymethyl)phenyl beta-D-glucopyranoside
Authors:Ye, F.Z., Wang, C., Chang, C.Q., Zhang, L.H., Gao, Y.G.
Deposit date:2019-04-28
Release date:2019-10-09
Last modified:2019-11-06
Method:X-RAY DIFFRACTION (1.804 Å)
Cite:Agrobacteria reprogram virulence gene expression by controlled release of host-conjugated signals.
Proc.Natl.Acad.Sci.USA, 116, 2019
6RJK
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STRUCTURE OF VIRULENCE FACTOR SGHA FROM AGROBACTERIUM TUMEFACIENS
Descriptor:Beta-glucosidase
Authors:Ye, F.Z., Wang, C., Chang, C.Q., Zhang, L.H., Gao, Y.G.
Deposit date:2019-04-27
Release date:2019-10-09
Last modified:2019-11-06
Method:X-RAY DIFFRACTION (1.922 Å)
Cite:Agrobacteria reprogram virulence gene expression by controlled release of host-conjugated signals.
Proc.Natl.Acad.Sci.USA, 116, 2019
6RJM
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COMPLEX STRUCTURE OF VIRULENCE FACTOR SGHA AND ITS HYDROLYSIS PRODUCT GLUCOSE
Descriptor:Beta-glucosidase, ALPHA-D-GLUCOSE
Authors:Ye, F.Z., Wang, C., Chang, C.Q., Zhang, L.H., Gao, Y.G.
Deposit date:2019-04-27
Release date:2019-10-09
Last modified:2019-11-06
Method:X-RAY DIFFRACTION (2.112 Å)
Cite:Agrobacteria reprogram virulence gene expression by controlled release of host-conjugated signals.
Proc.Natl.Acad.Sci.USA, 116, 2019
6OJJ
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STRUCTURE OF SCATG3 WITH TRUNCATIONS IN N-TERMINAL AND FLEXIBLE REGION (FR)
Descriptor:Autophagy-related protein 3,Autophagy-related protein 3, GLYCEROL
Authors:Zheng, Y., Qiu, Y., Schulman, B.A.
Deposit date:2019-04-11
Release date:2019-08-21
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (2.406 Å)
Cite:A switch element in the autophagy E2 Atg3 mediates allosteric regulation across the lipidation cascade.
Nat Commun, 10, 2019
6JNI
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CRYSTAL STRUCTURE OF THE TRANSCRIPTIONAL REGULATOR CADR FROM P. PUTIDA IN COMPLEX WITH ZINC(II) AND DNA
Descriptor:CadR, DNA (25-MER), ZINC ION
Authors:Liu, X.C., Gan, J.H., Chen, H.
Deposit date:2019-03-16
Release date:2019-09-25
Last modified:2019-10-23
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Selective cadmium regulation mediated by a cooperative binding mechanism in CadR.
Proc.Natl.Acad.Sci.USA, 116, 2019
6JKK
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CRYSTAL STRUCTURE OF BUBR1 KINASE DOMAIN
Descriptor:Mitotic checkpoint control protein kinase BUB1, GLYCEROL, DI(HYDROXYETHYL)ETHER
Authors:Lin, L., Ye, S., Huang, Y., Liu, X., Zhang, R., Yao, X.
Deposit date:2019-03-01
Release date:2019-06-26
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:BubR1 phosphorylates CENP-E as a switch enabling the transition from lateral association to end-on capture of spindle microtubules.
Cell Res., 29, 2019
6JKM
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CRYSTAL STRUCTURE OF BUBR1 KINASE DOMAIN
Descriptor:Mitotic checkpoint control protein kinase BUB1, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Lin, L., Ye, S., Huang, Y., Liu, X., Zhang, R., Yao, X.
Deposit date:2019-03-01
Release date:2019-06-26
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:BubR1 phosphorylates CENP-E as a switch enabling the transition from lateral association to end-on capture of spindle microtubules.
Cell Res., 29, 2019
6JGV
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CRYSTAL STRUCTURE OF THE TRANSCRIPTIONAL REGULATOR CADR FROM P. PUTIDA
Descriptor:CadR
Authors:Liu, X.C., Gan, J.H., Chen, H.
Deposit date:2019-02-15
Release date:2019-09-25
Last modified:2019-10-23
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Selective cadmium regulation mediated by a cooperative binding mechanism in CadR.
Proc.Natl.Acad.Sci.USA, 116, 2019
6JGW
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CRYSTAL STRUCTURE OF THE TRANSCRIPTIONAL REGULATOR CADR FROM P. PUTIDA IN COMPLEX WITH DNA
Descriptor:CadR, DNA (27-MER)
Authors:Liu, X.C., Gan, J.H., Chen, H.
Deposit date:2019-02-15
Release date:2019-09-25
Last modified:2019-10-23
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Selective cadmium regulation mediated by a cooperative binding mechanism in CadR.
Proc.Natl.Acad.Sci.USA, 116, 2019
6JGX
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CRYSTAL STRUCTURE OF THE TRANSCRIPTIONAL REGULATOR CADR FROM P. PUTIDA IN COMPLEX WITH CADMIUM(II) AND DNA
Descriptor:CadR, DNA (5'-D(*CP*AP*CP*CP*CP*TP*AP*TP*AP*GP*TP*GP*GP*CP*TP*AP*CP*AP*GP*GP*GP*T)-3'), DNA (5'-D(*GP*AP*CP*CP*CP*TP*GP*TP*AP*GP*CP*CP*AP*CP*TP*AP*TP*AP*GP*GP*GP*T)-3'), ...
Authors:Liu, X.C., Gan, J.H., Chen, H.
Deposit date:2019-02-15
Release date:2019-09-25
Last modified:2019-10-23
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Selective cadmium regulation mediated by a cooperative binding mechanism in CadR.
Proc.Natl.Acad.Sci.USA, 116, 2019
6JGF
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CRYSTAL STRUCTURE OF SE-MET CADR FROM P. PUTIDA WITH A 21 RESIDUE C-TERMINAL TRUNCATION
Descriptor:CadR, PHOSPHATE ION
Authors:Liu, X.C., Gan, J.H., Chen, H.
Deposit date:2019-02-13
Release date:2019-09-25
Last modified:2019-10-23
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Selective cadmium regulation mediated by a cooperative binding mechanism in CadR.
Proc.Natl.Acad.Sci.USA, 116, 2019
6NWK
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STRUCTURE OF THE ANCESTRAL GLUCOCORTICOID RECEPTOR 2 LIGAND BINDING DOMAIN IN COMPLEX WITH DEXAMETHASONE AND PGC1A COREGULATOR FRAGMENT
Descriptor:glucocorticoid receptor, Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, DEXAMETHASONE, ...
Authors:Liu, X., Ortlund, E.A.
Deposit date:2019-02-06
Release date:2019-10-23
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:First High-Resolution Crystal Structures of the Glucocorticoid Receptor Ligand-Binding Domain-Peroxisome Proliferator-ActivatedgammaCoactivator 1-alphaComplex with Endogenous and Synthetic Glucocorticoids.
Mol.Pharmacol., 96, 2019
6NWL
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STRUCTURE OF THE ANCESTRAL GLUCOCORTICOID RECEPTOR 2 LIGAND BINDING DOMAIN IN COMPLEX WITH HYDROCORTISONE AND PGC1A COREGULATOR FRAGMENT
Descriptor:glucocorticoid receptor, Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, (11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione, ...
Authors:Liu, X., Ortlund, E.A.
Deposit date:2019-02-06
Release date:2019-10-23
Method:X-RAY DIFFRACTION (1.595 Å)
Cite:First High-Resolution Crystal Structures of the Glucocorticoid Receptor Ligand-Binding Domain-Peroxisome Proliferator-ActivatedgammaCoactivator 1-alphaComplex with Endogenous and Synthetic Glucocorticoids.
Mol.Pharmacol., 96, 2019
6JBZ
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STRUCTURAL ANALYSIS OF MOLYBDOPTERIN SYNTHASES FROM TWO MYCOBACTERIA PATHOGENS
Descriptor:Molybdenum cofactor biosynthesis protein E, MoaD/ThiS family protein, SULFATE ION
Authors:Wang, H.Y., Liu, X.
Deposit date:2019-01-27
Release date:2019-02-13
Last modified:2019-03-13
Method:X-RAY DIFFRACTION (2.603 Å)
Cite:Structural analysis of molybdopterin synthases from two mycobacterial pathogens.
Biochem. Biophys. Res. Commun., 511, 2019
6JC0
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STRUCTURAL ANALYSIS OF MOLYBDOPTERIN SYNTHASES FROM TWO MYCOBACTERIA PATHOGENS
Descriptor:Putative molybdenum cofactor biosynthesis protein, Putative molybdenum cofactor biosynthesis protein D2 (MoaD2) / thiamine S
Authors:Liu, X., Wang, H.Y.
Deposit date:2019-01-27
Release date:2019-02-13
Last modified:2019-03-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural analysis of molybdopterin synthases from two mycobacterial pathogens.
Biochem. Biophys. Res. Commun., 511, 2019
6J6M
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CO-CRYSTAL STRUCTURE OF BTK KINASE DOMAIN WITH ZANUBRUTINIB
Descriptor:Tyrosine-protein kinase BTK, (7S)-2-(4-phenoxyphenyl)-7-(1-propanoylpiperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide, IMIDAZOLE
Authors:Zhou, X., Hong, Y.
Deposit date:2019-01-15
Release date:2019-10-23
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Discovery of Zanubrutinib (BGB-3111), a Novel, Potent, and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase.
J.Med.Chem., 62, 2019
6NJA
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STRUCTURE OF WT RET PROTEIN TYROSINE KINASE DOMAIN AT 1.92A RESOLUTION.
Descriptor:Proto-oncogene tyrosine-protein kinase receptor Ret, ADENINE, FORMIC ACID
Authors:Terzyan, S.S., Shen, T., Wu, J., Mooers, B.H.M.
Deposit date:2019-01-02
Release date:2019-06-05
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Structural basis of resistance of mutant RET protein-tyrosine kinase to its inhibitors nintedanib and vandetanib.
J.Biol.Chem., 294, 2019
6NE7
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STRUCTURE OF G810A MUTANT OF RET PROTEIN TYROSINE KINASE DOMAIN.
Descriptor:Proto-oncogene tyrosine-protein kinase receptor Ret, FORMIC ACID, ADENOSINE MONOPHOSPHATE
Authors:Terzyan, S.S., Shen, T., Wu, J., Mooers, B.H.M.
Deposit date:2018-12-17
Release date:2019-06-05
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Structural basis of resistance of mutant RET protein-tyrosine kinase to its inhibitors nintedanib and vandetanib.
J.Biol.Chem., 294, 2019
6NEC
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STRUCTURE OF RET PROTEIN TYROSINE KINASE DOMAIN IN COMPLEX WITH NINTEDANIB
Descriptor:Proto-oncogene tyrosine-protein kinase receptor Ret, methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1H-indole-6-carboxylate, FORMIC ACID
Authors:Terzyan, S.S., Shen, T., Wu, J., Mooers, B.H.M.
Deposit date:2018-12-17
Release date:2019-06-05
Last modified:2019-09-25
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Structural basis of resistance of mutant RET protein-tyrosine kinase to its inhibitors nintedanib and vandetanib.
J.Biol.Chem., 294, 2019
6IY2
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STRUCTURE OF SNF2-MMTV-A NUCLEOSOME COMPLEX AT SHL2 IN ADP STATE
Descriptor:Histone H3, Histone H4, Histone H2A, ...
Authors:Li, M., Xia, X., Liu, X., Li, X., Chen, Z.
Deposit date:2018-12-12
Release date:2019-04-03
Method:ELECTRON MICROSCOPY (3.47 Å)
Cite:Mechanism of DNA translocation underlying chromatin remodelling by Snf2.
Nature, 567, 2019
6IY3
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STRUCTURE OF SNF2-MMTV-A NUCLEOSOME COMPLEX AT SHL-2 IN ADP STATE
Descriptor:Histone H3, Histone H4, Histone H2A, ...
Authors:Li, M., Xia, X., Liu, X., Li, X., Chen, Z.
Deposit date:2018-12-12
Release date:2019-04-03
Method:ELECTRON MICROSCOPY (3.67 Å)
Cite:Mechanism of DNA translocation underlying chromatin remodelling by Snf2.
Nature, 567, 2019