Author results

4C11
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DENGUE VIRUS RNA DEPENDENT RNA POLYMERASE WITH RESIDUES FROM THE NS5 LINKER REGION
Descriptor:DENGUE VIRUS TYPE 3 RNA DEPENDENT RNA POLYMERASE, ZINC ION
Authors:Lim, S.P., Lescar, J.
Deposit date:2013-08-09
Release date:2013-08-21
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A Crystal Structure of the Dengue Virus Ns5 Polymerase Delineates Inter-Domain Amino Acids Residues that Enhance its Thermostability and De Novo Initiation Activities.
J.Biol.Chem., 288, 2013
2JLQ
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DENGUE VIRUS 4 NS3 HELICASE STRUCTURE, APO ENZYME.
Descriptor:SERINE PROTEASE SUBUNIT NS3, CHLORIDE ION, GLYCEROL
Authors:Luo, D.H., Xu, T., Watson, R.P., Becker, D.S., Sampath, A., Jahnke, W., Yeong, S.S., Wang, C.H., Lim, S.P., Vasudevan, S.G., Lescar, J.
Deposit date:2008-09-15
Release date:2008-11-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Insights Into RNA Unwinding and ATP Hydrolysis by the Flavivirus Ns3 Protein.
Embo J., 27, 2008
2JLR
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DENGUE VIRUS 4 NS3 HELICASE IN COMPLEX WITH AMPPNP
Descriptor:SERINE PROTEASE SUBUNIT NS3, MANGANESE (II) ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Luo, D.H., Xu, T., Watson, R.P., Becker, D.S., Sampath, A., Jahnke, W., Yeong, S.S., Wang, C.H., Lim, S.P., Vasudevan, S.G., Lescar, J.
Deposit date:2008-09-15
Release date:2008-11-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Insights Into RNA Unwinding and ATP Hydrolysis by the Flavivirus Ns3 Protein.
Embo J., 27, 2008
2JLS
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DENGUE VIRUS 4 NS3 HELICASE IN COMPLEX WITH ADP
Descriptor:SERINE PROTEASE SUBUNIT NS3, MANGANESE (II) ION, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Luo, D.H., Xu, T., Watson, R.P., Becker, D.S., Sampath, A., Jahnke, W., Yeong, S.S., Wang, C.H., Lim, S.P., Vasudevan, S.G., Lescar, J.
Deposit date:2008-09-15
Release date:2008-11-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Insights Into RNA Unwinding and ATP Hydrolysis by the Flavivirus Ns3 Protein.
Embo J., 27, 2008
2JLU
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DENGUE VIRUS 4 NS3 HELICASE IN COMPLEX WITH SSRNA
Descriptor:SERINE PROTEASE SUBUNIT NS3, 5'-R(*AP*GP*AP*CP*UP*AP*AP*CP*AP*AP*CP*U)-3', GLYCEROL
Authors:Luo, D.H., Xu, T., Watson, R.P., Becker, D.S., Sampath, A., Jahnke, W., Yeong, S.S., Wang, C.H., Lim, S.P., Vasudevan, S.G., Lescar, J.
Deposit date:2008-09-15
Release date:2008-11-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Insights Into RNA Unwinding and ATP Hydrolysis by the Flavivirus Ns3 Protein.
Embo J., 27, 2008
2JLV
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DENGUE VIRUS 4 NS3 HELICASE IN COMPLEX WITH SSRNA AND AMPPNP
Descriptor:SERINE PROTEASE SUBUNIT NS3, 5'-R(*AP*GP*AP*CP*UP*AP*AP*CP*AP*AP*CP*U)-3', PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Luo, D.H., Xu, T., Watson, R.P., Becker, D.S., Sampath, A., Jahnke, W., Yeong, S.S., Wang, C.H., Lim, S.P., Vasudevan, S.G., Lescar, J.
Deposit date:2008-09-15
Release date:2008-11-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Insights Into RNA Unwinding and ATP Hydrolysis by the Flavivirus Ns3 Protein
Embo J., 27, 2008
2JLW
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DENGUE VIRUS 4 NS3 HELICASE IN COMPLEX WITH SSRNA2
Descriptor:SERINE PROTEASE SUBUNIT NS3, 5'-R(*UP*AP*GP*AP*CP*UP*AP*AP*CP*AP*AP*CP*U)-3', PHOSPHATE ION, ...
Authors:Luo, D.H., Xu, T., Watson, R.P., Becker, D.S., Sampath, A., Jahnke, W., Yeong, S.S., Wang, C.H., Lim, S.P., Vasudevan, S.G., Lescar, J.
Deposit date:2008-09-15
Release date:2008-11-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Insights Into RNA Unwinding and ATP Hydrolysis by the Flavivirus Ns3 Protein
Embo J., 27, 2008
2JLX
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DENGUE VIRUS 4 NS3 HELICASE IN COMPLEX WITH SSRNA AND ADP-VANADATE
Descriptor:SERINE PROTEASE SUBUNIT NS3, 5'-R(*AP*GP*AP*CP*UP*AP*AP*CP*AP*AP*CP*U)-3', ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Luo, D.H., Xu, T., Watson, R.P., Becker, D.S., Sampath, A., Jahnke, W., Yeong, S.S., Wang, C.H., Lim, S.P., Vasudevan, S.G., Lescar, J.
Deposit date:2008-09-15
Release date:2008-11-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Insights Into RNA Unwinding and ATP Hydrolysis by the Flavivirus Ns3 Protein.
Embo J., 27, 2008
2JLY
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DENGUE VIRUS 4 NS3 HELICASE IN COMPLEX WITH SSRNA AND ADP-PHOSPHATE
Descriptor:SERINE PROTEASE SUBUNIT NS3, 5'-R(*AP*GP*AP*CP*UP*AP*AP*CP*AP*AP*CP*U)-3', ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Luo, D.H., Xu, T., Watson, R.P., Becker, D.S., Sampath, A., Jahnke, W., Yeong, S.S., Wang, C.H., Lim, S.P., Vasudevan, S.G., Lescar, J.
Deposit date:2008-09-15
Release date:2008-11-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Insights Into RNA Unwinding and ATP Hydrolysis by the Flavivirus Ns3 Protein.
Embo J., 27, 2008
2JLZ
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DENGUE VIRUS 4 NS3 HELICASE IN COMPLEX WITH SSRNA AND ADP
Descriptor:SERINE PROTEASE SUBUNIT NS3, 5'-R(*AP*GP*AP*CP*UP*AP*AP*CP*AP*AP*CP*U)-3', ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Luo, D.H., Xu, T., Watson, R.P., Becker, D.S., Sampath, A., Jahnke, W., Yeong, S.S., Wang, C.H., Lim, S.P., Vasudevan, S.G., Lescar, J.
Deposit date:2008-09-15
Release date:2008-11-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Insights Into RNA Unwinding and ATP Hydrolysis by the Flavivirus Ns3 Protein.
Embo J., 27, 2008
2XBM
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CRYSTAL STRUCTURE OF THE DENGUE VIRUS METHYLTRANSFERASE BOUND TO A 5'- CAPPED OCTAMERIC RNA
Descriptor:NONSTRUCTURAL PROTEIN NS5, 5'-(*G3AP*GP*AP*AP*CP*CP*UP*GP*A)-3', SULFATE ION, ...
Authors:Yap, L.J., Luo, D.H., Chung, K.Y., Lim, S.P., Bodenreider, C., Noble, C., Shi, P.Y., Lescar, J.
Deposit date:2010-04-13
Release date:2010-09-29
Last modified:2012-04-04
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal Structure of the Dengue Virus Methyltransferase Bound to a 5'-Capped Octameric RNA
Plos One, 5, 2010
4V0Q
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DENGUE VIRUS FULL LENGTH NS5 COMPLEXED WITH SAH
Descriptor:NS5 POLYMERASE, ZINC ION, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Zhao, Y., Soh, S., Zheng, J., Phoo, W.W., Swaminathan, K., Cornvik, T.C., Lim, S.P., Shi, P.-Y., Lescar, J., Vasudevan, S.G., Luo, D.
Deposit date:2014-09-18
Release date:2015-01-28
Last modified:2018-06-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A Crystal Structure of the Dengue Virus Ns5 Protein Reveals a Novel Inter-Domain Interface Essential for Protein Flexibility and Virus Replication.
Plos Pathog., 11, 2015
4V0R
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DENGUE VIRUS FULL LENGTH NS5 COMPLEXED WITH GTP AND SAH
Descriptor:NS5 POLYMERASE, ZINC ION, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Zhao, Y., Soh, S., Zheng, J., Phoo, W.W., Swaminathan, K., Cornvik, T.C., Lim, S.P., Shi, P.-Y., Lescar, J., Vasudevan, S.G., Luo, D.
Deposit date:2014-09-18
Release date:2015-01-28
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A Crystal Structure of the Dengue Virus Ns5 Protein Reveals a Novel Inter-Domain Interface Essential for Protein Flexibility and Virus Replication.
Plos Pathog., 11, 2015
5DTO
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DENGUE VIRUS FULL LENGTH NS5 COMPLEXED WITH VIRAL CAP 0-RNA AND SAH
Descriptor:NS5, RNA (5'-R(P*AP*GP*UP*U)-3'), ZINC ION, ...
Authors:Zhao, Y., Soh, T.S., Lim, S.P., Chung, K.Y., Swaminathan, K., Vasudevan, S.G., Shi, P.-Y., Lescar, J., Luo, D.
Deposit date:2015-09-18
Release date:2015-11-25
Last modified:2015-12-16
Method:X-RAY DIFFRACTION (2.603 Å)
Cite:Molecular basis for specific viral RNA recognition and 2'-O-ribose methylation by the dengue virus nonstructural protein 5 (NS5)
Proc.Natl.Acad.Sci.USA, 112, 2015
5ZQK
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DENGUE VIRUS NON STRUCTURAL PROTEIN 5
Descriptor:Non Structural Protein 5, S-ADENOSYLMETHIONINE, GLYCEROL, ...
Authors:El Sahili, A., Soh, T.S., Schiltz, J., Gharbi-Ayachi, A., Goh, B.C., Seh, C.C., Dedon, P.C., Shi, P.Y., Lim, S.P., Lescar, J.
Deposit date:2018-04-19
Release date:2019-06-12
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A conformation of Dengue virus serotype 2 NS5 akin to its ZIKV and JEV homologues.
To Be Published
3P8Z
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DENGUE METHYLTRANSFERASE BOUND TO A SAM-BASED INHIBITOR
Descriptor:Non-structural protein 5, (S)-2-amino-4-(((2S,3S,4R,5R)-5-(6-(3-chlorobenzylamino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methylthio)butanoic acid, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Noble, C.G., Yap, L.J., Lescar, J.
Deposit date:2010-10-15
Release date:2010-12-08
Last modified:2011-09-28
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Small molecule inhibitors that selectively block dengue virus methyltransferase
J.Biol.Chem., 286, 2011
3P97
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DENGUE 3 NS5 METHYLTRANSFERASE BOUND TO THE SUBSTRATE S-ADENOSYL METHIONINE
Descriptor:Non-structural protein 5, S-ADENOSYLMETHIONINE
Authors:Noble, C.G., Yap, L.J., Lescar, J.
Deposit date:2010-10-16
Release date:2010-12-08
Last modified:2011-09-28
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Small molecule inhibitors that selectively block dengue virus methyltransferase
J.Biol.Chem., 286, 2011
5I3P
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DENGUE SEROTYPE 3 RNA-DEPENDENT RNA POLYMERASE BOUND TO COMPOUND 27
Descriptor:Genome polyprotein, ZINC ION, 5-[5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl]-2,4-dimethoxy-N-[(3-methoxyphenyl)sulfonyl]benzamide
Authors:Noble, C.G.
Deposit date:2016-02-10
Release date:2016-07-06
Last modified:2016-08-24
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling
Plos Pathog., 12, 2016
5I3Q
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DENGUE SEROTYPE 3 RNA-DEPENDENT RNA POLYMERASE BOUND TO COMPOUND 29
Descriptor:Genome polyprotein, ZINC ION, 5-[5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl]-4-methoxy-2-methyl-N-[(quinolin-8-yl)sulfonyl]benzamide
Authors:Noble, C.G.
Deposit date:2016-02-10
Release date:2016-07-06
Last modified:2016-08-24
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling
Plos Pathog., 12, 2016
5JJR
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DENGUE 3 NS5 PROTEIN WITH COMPOUND 29
Descriptor:Genome polyprotein, ZINC ION, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Lescar, J., El Sahili, A.
Deposit date:2016-04-25
Release date:2016-07-06
Last modified:2016-08-24
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling
Plos Pathog., 12, 2016
5JJS
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DENGUE 3 NS5 PROTEIN WITH COMPOUND 27
Descriptor:Genome polyprotein, ZINC ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Lescar, J., El Sahili, A.
Deposit date:2016-04-25
Release date:2016-07-06
Last modified:2016-08-24
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling
Plos Pathog., 12, 2016
5K5M
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CO-CRYSTAL STRUCTURE OF DENGUE VIRUS SEROTYPE 2 RNA DEPENDENT RNA POLYMERASE WITH COMPOUND 27
Descriptor:RNA Dependent RNA Polymerase, ZINC ION, 5-[5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl]-2,4-dimethoxy-N-[(3-methoxyphenyl)sulfonyl]benzamide, ...
Authors:Arora, R., Benson, T.E.
Deposit date:2016-05-23
Release date:2016-08-24
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling.
Plos Pathog., 12, 2016
2FOM
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DENGUE VIRUS NS2B/NS3 PROTEASE
Descriptor:polyprotein, CHLORIDE ION, GLYCEROL
Authors:Schiering, N., Kroemer, M., Renatus, M., Erbel, P., D'Arcy, A.
Deposit date:2006-01-13
Release date:2006-03-07
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus.
Nat.Struct.Mol.Biol., 13, 2006
2FP7
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WEST NILE VIRUS NS2B/NS3PROTEASE IN COMPLEX WITH BZ-NLE-LYS-ARG-ARG-H
Descriptor:Genome polyprotein, N-benzoyl-L-norleucyl-L-lysyl-N-[(2S)-5-carbamimidamido-1-hydroxypentan-2-yl]-L-argininamide
Authors:Schiering, N., D'Arcy, A., Erbel, P.
Deposit date:2006-01-16
Release date:2006-03-07
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus.
Nat.Struct.Mol.Biol., 13, 2006
3LKZ
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STRUCTURAL AND FUNCTIONAL ANALYSES OF A CONSERVED HYDROPHOBIC POCKET OF FLAVIVIRUS METHYLTRANSFERASE
Descriptor:Non-structural protein 5, SINEFUNGIN, GLYCEROL
Authors:Liu, L.H., Li, H.M.
Deposit date:2010-01-28
Release date:2010-08-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and functional analyses of a conserved hydrophobic pocket of flavivirus methyltransferase.
J.Biol.Chem., 285, 2010
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