5I3P

DENGUE SEROTYPE 3 RNA-DEPENDENT RNA POLYMERASE BOUND TO COMPOUND 27

Summary for 5I3P

• Entry DOI: 10.2210/pdb5i3p/pdb
• Related: 5I3Q
• Descriptor: Genome polyprotein, ZINC ION, 5-[5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl]-2,4-dimethoxy-N-[(3-methoxyphenyl)sulfonyl]benzamide, ... (4 entities in total)
• Functional Keywords: polymerase, dengue, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Dengue virus 3
• Cellular location: Virion membrane ; Multi-pass membrane protein : Q6DLV0
• Total number of polymer chains: 1
• Total formula weight: 74243.23

Authors

Noble, C.G. (deposition date: 2016-02-10, release date: 2016-07-06, Last modification date: 2023-11-08)

• Primary citation: Lim, S.P.,Noble, C.G.,Seh, C.C.,Soh, T.S.,El Sahili, A.,Chan, G.K.,Lescar, J.,Arora, R.,Benson, T.,Nilar, S.,Manjunatha, U.,Wan, K.F.,Dong, H.,Xie, X.,Shi, P.Y.,Yokokawa, F.; Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling; Plos Pathog., 12:e1005737-e1005737, 2016; PubMed: 27500641; DOI: 10.1371/journal.ppat.1005737

Experimental method

X-RAY DIFFRACTION (2.45 Å)