5I3P
DENGUE SEROTYPE 3 RNA-DEPENDENT RNA POLYMERASE BOUND TO COMPOUND 27
Summary for 5I3P
Entry DOI | 10.2210/pdb5i3p/pdb |
Related | 5I3Q |
Descriptor | Genome polyprotein, ZINC ION, 5-[5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl]-2,4-dimethoxy-N-[(3-methoxyphenyl)sulfonyl]benzamide, ... (4 entities in total) |
Functional Keywords | polymerase, dengue, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Dengue virus 3 |
Cellular location | Virion membrane ; Multi-pass membrane protein : Q6DLV0 |
Total number of polymer chains | 1 |
Total formula weight | 74243.23 |
Authors | Noble, C.G. (deposition date: 2016-02-10, release date: 2016-07-06, Last modification date: 2023-11-08) |
Primary citation | Lim, S.P.,Noble, C.G.,Seh, C.C.,Soh, T.S.,El Sahili, A.,Chan, G.K.,Lescar, J.,Arora, R.,Benson, T.,Nilar, S.,Manjunatha, U.,Wan, K.F.,Dong, H.,Xie, X.,Shi, P.Y.,Yokokawa, F. Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling Plos Pathog., 12:e1005737-e1005737, 2016 Cited by PubMed: 27500641DOI: 10.1371/journal.ppat.1005737 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.45 Å) |
Structure validation
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