3P8Z

Dengue Methyltransferase bound to a SAM-based inhibitor

Summary for 3P8Z

• Entry DOI: 10.2210/pdb3p8z/pdb
• Related: 3P97
• Descriptor: Non-structural protein 5, (S)-2-amino-4-(((2S,3S,4R,5R)-5-(6-(3-chlorobenzylamino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methylthio)butanoic acid, S-ADENOSYL-L-HOMOCYSTEINE, ... (4 entities in total)
• Functional Keywords: methyltransferase, rna, er, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Dengue virus 3
• Cellular location: Envelope protein E: Virion membrane; Multi- pass membrane protein: C1KBQ3
• Total number of polymer chains: 2
• Total formula weight: 61032.56

Authors

Noble, C.G.,Yap, L.J.,Lescar, J. (deposition date: 2010-10-15, release date: 2010-12-08, Last modification date: 2023-11-01)

• Primary citation: Lim, S.P.,Sonntag, L.S.,Noble, C.,Nilar, S.H.,Ng, R.H.,Zou, G.,Monaghan, P.,Chung, K.Y.,Dong, H.,Liu, B.,Bodenreider, C.,Lee, G.,Ding, M.,Chan, W.L.,Wang, G.,Jian, Y.L.,Chao, A.T.,Lescar, J.,Yin, Z.,Vedananda, T.R.,Keller, T.H.,Shi, P.Y.; Small molecule inhibitors that selectively block dengue virus methyltransferase; J.Biol.Chem., 286:6233-6240, 2011; PubMed: 21147775; DOI: 10.1074/jbc.M110.179184

Experimental method