5K5M
Co-Crystal Structure of Dengue Virus Serotype 2 RNA Dependent RNA Polymerase with Compound 27
Summary for 5K5M
Entry DOI | 10.2210/pdb5k5m/pdb |
Descriptor | RNA Dependent RNA Polymerase, ZINC ION, 5-[5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl]-2,4-dimethoxy-N-[(3-methoxyphenyl)sulfonyl]benzamide, ... (5 entities in total) |
Functional Keywords | rna dependent rna polymerase, dengue, hydrolase |
Biological source | Dengue virus 2 |
Cellular location | Virion membrane ; Multi-pass membrane protein : B5LNH6 |
Total number of polymer chains | 1 |
Total formula weight | 74590.49 |
Authors | Arora, R.,Benson, T.E. (deposition date: 2016-05-23, release date: 2016-08-24, Last modification date: 2024-03-06) |
Primary citation | Lim, S.P.,Noble, C.G.,Seh, C.C.,Soh, T.S.,El Sahili, A.,Chan, G.K.,Lescar, J.,Arora, R.,Benson, T.,Nilar, S.,Manjunatha, U.,Wan, K.F.,Dong, H.,Xie, X.,Shi, P.Y.,Yokokawa, F. Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling. Plos Pathog., 12:e1005737-e1005737, 2016 Cited by PubMed: 27500641DOI: 10.1371/journal.ppat.1005737 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.01 Å) |
Structure validation
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