5K5M

Co-Crystal Structure of Dengue Virus Serotype 2 RNA Dependent RNA Polymerase with Compound 27

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003968	molecular_function	RNA-directed RNA polymerase activity
A	0005524	molecular_function	ATP binding
A	0039694	biological_process	viral RNA genome replication

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 1001

Chain	Residue
A	HIS712
A	HIS714
A	CYS728
A	CYS847

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site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 1002

Chain	Residue
A	GLU438
A	HIS442
A	CYS447
A	CYS450

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site_id	AC3
Number of Residues	18
Details	binding site for residue 68T A 1003

Chain	Residue
A	HIS513
A	CYS709
A	SER710
A	HIS711
A	ARG729
A	ARG737
A	THR794
A	TRP795
A	SER796
A	HIS798
A	ALA799
A	LYS800
A	GLU802
A	TRP803
A	HOH1109
A	HOH1110
A	HOH1300
A	LEU512

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site_id	AC4
Number of Residues	10
Details	binding site for residue MES A 1004

Chain	Residue
A	VAL321
A	GLY323
A	GLY323
A	ARG326
A	ARG326
A	LEU327
A	LEU327
A	LEU748
A	LEU748
A	LEU873

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