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2W0T
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SOLUTION STRUCTURE OF THE FCS ZINC FINGER DOMAIN OF HUMAN LMBL2
Descriptor:LETHAL(3)MALIGNANT BRAIN TUMOR-LIKE 2 PROTEIN, ZINC ION
Authors:Lechtenberg, B.C., Allen, M.D., Bycroft, M.
Deposit date:2008-10-10
Release date:2009-01-20
Last modified:2017-04-19
Method:SOLUTION NMR
Cite:Solution Structure of the Fcs Zinc Finger Domain of the Human Polycomb Group Protein L(3)Mbt-Like 2.
Protein Sci., 18, 2009
4BXS
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CRYSTAL STRUCTURE OF THE PROTHROMBINASE COMPLEX FROM THE VENOM OF PSEUDONAJA TEXTILIS
Descriptor:FACTOR X-LIKE PROTEASE, VENOM PROTHROMBIN ACTIVATOR PSEUTARIN-C NON-CATALYTIC SUBUNIT, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Lechtenberg, B.C., Murray-Rust, T.A., Johnson, D.J.D., Adams, T.E., Krishnaswamy, S., Camire, R.M., Huntington, J.A.
Deposit date:2013-07-15
Release date:2013-07-31
Last modified:2013-10-30
Method:X-RAY DIFFRACTION (3.32 Å)
Cite:Crystal Structure of the Prothrombinase Complex from the Venom of Pseudonaja Textilis.
Blood, 122, 2013
4BXW
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CRYSTAL STRUCTURE OF THE PROTHROMBINASE COMPLEX FROM THE VENOM OF PSEUDONAJA TEXTILIS
Descriptor:FACTOR XA, COAGULATION FACTOR V, L-alpha-glutamyl-N-{(1S)-4-{[amino(iminio)methyl]amino}-1-[(1S)-2-chloro-1-hydroxyethyl]butyl}glycinamide, ...
Authors:Lechtenberg, B.C., Murray-Rust, T.A., Johnson, D.J.D., Adams, T.E., Krishnaswamy, S., Camire, R.M., Huntington, J.A.
Deposit date:2013-07-16
Release date:2013-07-31
Last modified:2013-10-30
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Crystal Structure of the Prothrombinase Complex from the Venom of Pseudonaja Textilis.
Blood, 122, 2013
4CH2
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LOW-SALT CRYSTAL STRUCTURE OF A THROMBIN-GPIBALPHA PEPTIDE COMPLEX
Descriptor:THROMBIN, LIGHT CHAIN, HEAVY CHAIN, ...
Authors:Lechtenberg, B.C., Freund, S.M.V., Huntington, J.A.
Deposit date:2013-11-28
Release date:2013-12-11
Last modified:2014-02-12
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Gpibalpha Interacts Exclusively with Exosite II of Thrombin
J.Mol.Biol., 426, 2014
4CH8
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HIGH-SALT CRYSTAL STRUCTURE OF A THROMBIN-GPIBALPHA PEPTIDE COMPLEX
Descriptor:THROMBIN, LIGHT CHAIN, HEAVY CHAIN, ...
Authors:Lechtenberg, B.C., Freund, S.M.V., Huntington, J.A.
Deposit date:2013-11-29
Release date:2013-12-11
Last modified:2018-06-27
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Gpibalpha Interacts Exclusively with Exosite II of Thrombin
J.Mol.Biol., 426, 2014
4WVP
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CRYSTAL STRUCTURE OF AN ACTIVITY-BASED PROBE HNE COMPLEX
Descriptor:Neutrophil elastase, BTN-3V3-NLB-OMT-OIC-3V2, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Lechtenberg, B.C., Kasperkiewicz, P., Robinson, H.R., Drag, M., Riedl, S.J.
Deposit date:2014-11-06
Release date:2015-02-11
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:The Elastase-PK101 Structure: Mechanism of an Ultrasensitive Activity-based Probe Revealed.
Acs Chem.Biol., 10, 2015
5EDV
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STRUCTURE OF THE HOIP-RBR/UBCH5B~UBIQUITIN TRANSFER COMPLEX
Descriptor:E3 ubiquitin-protein ligase RNF31, Ubiquitin-conjugating enzyme E2 D2, Polyubiquitin-B, ...
Authors:Lechtenberg, B.C., Mace, P.D., Sanishvili, R., Riedl, S.J.
Deposit date:2015-10-22
Release date:2016-01-20
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (3.48 Å)
Cite:Structure of a HOIP/E2~ubiquitin complex reveals RBR E3 ligase mechanism and regulation.
Nature, 529, 2016
5V60
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PHOSPHO-ERK2 BOUND TO AMP-PCP
Descriptor:Mitogen-activated protein kinase 1, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, GLYCEROL, ...
Authors:Lechtenberg, B.C., Riedl, S.J.
Deposit date:2017-03-15
Release date:2017-07-26
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Structure-Guided Strategy for the Development of Potent Bivalent ERK Inhibitors.
ACS Med Chem Lett, 8, 2017
5V61
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PHOSPHO-ERK2 BOUND TO BIVALENT INHIBITOR SBP2
Descriptor:Mitogen-activated protein kinase 1, Ribosomal protein S6 kinase alpha-1,Protein Tat, GLYCEROL, ...
Authors:Lechtenberg, B.C., Riedl, S.J.
Deposit date:2017-03-15
Release date:2017-07-26
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure-Guided Strategy for the Development of Potent Bivalent ERK Inhibitors.
ACS Med Chem Lett, 8, 2017
5V62
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PHOSPHO-ERK2 BOUND TO BIVALENT INHIBITOR SBP3
Descriptor:Mitogen-activated protein kinase 1, Ribosomal protein S6 kinase alpha-1, GLYCEROL, ...
Authors:Lechtenberg, B.C., Riedl, S.J.
Deposit date:2017-03-15
Release date:2017-07-26
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure-Guided Strategy for the Development of Potent Bivalent ERK Inhibitors.
ACS Med Chem Lett, 8, 2017
4W4Z
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STRUCTURE OF THE EPHA4 LBD IN COMPLEX WITH PEPTIDE
Descriptor:Ephrin type-A receptor 4, APY-bAla8.am peptide, HEXANE-1,6-DIOL, ...
Authors:Lechtenberg, B.C., Mace, P.D., Riedl, S.J.
Deposit date:2014-08-15
Release date:2014-10-08
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Development and Structural Analysis of a Nanomolar Cyclic Peptide Antagonist for the EphA4 Receptor.
Acs Chem.Biol., 9, 2014
4W50
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STRUCTURE OF THE EPHA4 LBD IN COMPLEX WITH PEPTIDE
Descriptor:Ephrin type-A receptor 4, APY peptide, 1,3-BUTANEDIOL, ...
Authors:Lechtenberg, B.C., Mace, P.D., Riedl, S.J.
Deposit date:2014-08-16
Release date:2014-10-08
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Development and Structural Analysis of a Nanomolar Cyclic Peptide Antagonist for the EphA4 Receptor.
Acs Chem.Biol., 9, 2014
5JR2
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CRYSTAL STRUCTURE OF THE EPHA4 LBD IN COMPLEX WITH APYD3 PEPTIDE INHIBITOR
Descriptor:Ephrin type-A receptor 4, APYd3 peptide, HEXANE-1,6-DIOL, ...
Authors:Lechtenberg, B.C., Olson, E.J., Pasquale, E.B., Dawson, P.E., Riedl, S.J.
Deposit date:2016-05-05
Release date:2016-07-06
Last modified:2019-11-27
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Modifications of a Nanomolar Cyclic Peptide Antagonist for the EphA4 Receptor To Achieve High Plasma Stability.
Acs Med.Chem.Lett., 7, 2016
6NJZ
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EPHA2 LBD IN COMPLEX WITH YSA-GSGSK-BIO PEPTIDE
Descriptor:Ephrin type-A receptor 2, YSA-GSGSK-bio peptide, GLYCEROL, ...
Authors:Lechtenberg, B.C., Pasquale, E.B.
Deposit date:2019-01-04
Release date:2019-05-01
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Engineering nanomolar peptide ligands that differentially modulate EphA2 receptor signaling.
J.Biol.Chem., 294, 2019
6NK0
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EPHA2 LBD IN COMPLEX WITH BA-WLA-YAM PEPTIDE
Descriptor:Ephrin type-A receptor 2, bA-WLA-Yam, GLYCEROL, ...
Authors:Lechtenberg, B.C., Pasquale, E.B.
Deposit date:2019-01-04
Release date:2019-05-01
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Engineering nanomolar peptide ligands that differentially modulate EphA2 receptor signaling.
J.Biol.Chem., 294, 2019
6NK1
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EPHA2 LBD IN COMPLEX WITH BA-WLA-YRPKBIO PEPTIDE
Descriptor:Ephrin type-A receptor 2, bA-WLA-YRPKbio, ACETATE ION, ...
Authors:Lechtenberg, B.C., Pasquale, E.B.
Deposit date:2019-01-04
Release date:2019-05-01
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Engineering nanomolar peptide ligands that differentially modulate EphA2 receptor signaling.
J.Biol.Chem., 294, 2019
6NK2
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EPHA2 LBD IN COMPLEX WITH BA-WLA-YRPK BIO PEPTIDE
Descriptor:Ephrin type-A receptor 2, bA-WLA-YPRKbio peptide, DI(HYDROXYETHYL)ETHER
Authors:Lechtenberg, B.C., Pasquale, E.B.
Deposit date:2019-01-04
Release date:2019-05-01
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Engineering nanomolar peptide ligands that differentially modulate EphA2 receptor signaling.
J.Biol.Chem., 294, 2019
6NKP
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EPHA2 LBD IN COMPLEX WITH BA-WLA-YSKBIO PEPTIDE
Descriptor:Ephrin type-A receptor 2, bA-WLA-YSKbio peptide, BIOTIN
Authors:Lechtenberg, B.C., Pasquale, E.B.
Deposit date:2019-01-07
Release date:2019-05-01
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (2.033 Å)
Cite:Engineering nanomolar peptide ligands that differentially modulate EphA2 receptor signaling.
J.Biol.Chem., 294, 2019
6O5E
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CRYSTAL STRUCTURE OF THE VITRONECTIN HEMOPEXIN-LIKE DOMAIN
Descriptor:Vitronectin, SODIUM ION, CHLORIDE ION, ...
Authors:Lechtenberg, B.C., Shin, K., Marassi, F.M.
Deposit date:2019-03-01
Release date:2019-09-18
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of human Vitronectin C-terminal domain and interaction withYersinia pestisouter membrane protein Ail.
Sci Adv, 5, 2019
2VYT
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THE MBT REPEATS OF HUMAN SCML2 BIND TO PEPTIDES CONTAINING MONO METHYLATED LYSINE.
Descriptor:SEX COMB ON MIDLEG-LIKE PROTEIN 2, N-METHYL-LYSINE, TRIETHYLENE GLYCOL
Authors:Santiveri, C.M., Lechtenberg, B.C., Allen, M.D., Sathyamurthy, A., Jaulent, A.M., Freund, S.M.V., Bycroft, M.
Deposit date:2008-07-28
Release date:2008-08-05
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The Malignant Brain Tumor Repeats of Human Scml2 Bind to Peptides Containing Monomethylated Lysine.
J.Mol.Biol., 382, 2008
2BIV
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CRYSTAL STRUCTURE OF THE WILD-TYPE MBT DOMAINS OF HUMAN SCML2
Descriptor:SEX COMB ON MIDLEG-LIKE PROTEIN 2, IODIDE ION, SODIUM ION
Authors:Santiveri, C.M., Allen, M.D., Sait, F., Bycroft, M.
Deposit date:2005-01-26
Release date:2005-02-08
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The Malignant Brain Tumor Repeats of Human Scml2 Bind to Peptides Containing Monomethylated Lysine.
J.Mol.Biol., 382, 2008
6XA9
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SARS COV-2 PLPRO IN COMPLEX WITH ISG15 C-TERMINAL DOMAIN PROPARGYLAMIDE
Descriptor:Papain-like protease, ISG15 CTD-propargylamide, GLYCEROL, ...
Authors:Klemm, T., Calleja, D.J., Richardson, L.W., Lechtenberg, B.C., Komander, D.
Deposit date:2020-06-04
Release date:2020-06-17
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:SARS CoV-2 PLpro in complex with ISG15 C-terminal domain propargylamide
To Be Published
6XAA
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SARS COV-2 PLPRO IN COMPLEX WITH UBIQUITIN PROPARGYLAMIDE
Descriptor:Papain-like protease, Ubiquitin-propargylamide, ZINC ION
Authors:Klemm, T., Calleja, D.J., Richardson, L.W., Lechtenberg, B.C., Komander, D.
Deposit date:2020-06-04
Release date:2020-06-17
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:SARS CoV-2 PLpro in complex with ubiquitin propargylamide
To Be Published