7KJC

Crystal structure of the EphA2 S901E mutant intracellular KD-SAM domains

Summary for 7KJC

Entry DOI	10.2210/pdb7kjc/pdb
Descriptor	Ephrin type-A receptor 2, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	eph receptor, kinase, sam, allostery, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	89404.41
Authors	Lechtenberg, B.C.,Pasquale, E.B. (deposition date: 2020-10-26, release date: 2021-02-03, Last modification date: 2023-10-18)
Primary citation	Lechtenberg, B.C.,Gehring, M.P.,Light, T.P.,Horne, C.R.,Matsumoto, M.W.,Hristova, K.,Pasquale, E.B. Regulation of the EphA2 receptor intracellular region by phosphomimetic negative charges in the kinase-SAM linker. Nat Commun, 12:7047-7047, 2021 Cited by PubMed: 34857764 DOI: 10.1038/s41467-021-27343-z PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation