4WVP
Crystal structure of an activity-based probe HNE complex
Summary for 4WVP
Entry DOI | 10.2210/pdb4wvp/pdb |
Related PRD ID | PRD_002139 |
Descriptor | Neutrophil elastase, BTN-3V3-NLB-OMT-OIC-3V2, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total) |
Functional Keywords | neutrophil elastase, acitivity-based probe, inhibitor, protease, complex, hne, hycosul, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 26429.16 |
Authors | Lechtenberg, B.C.,Kasperkiewicz, P.,Robinson, H.R.,Drag, M.,Riedl, S.J. (deposition date: 2014-11-06, release date: 2015-02-11, Last modification date: 2023-11-15) |
Primary citation | Lechtenberg, B.C.,Kasperkiewicz, P.,Robinson, H.,Drag, M.,Riedl, S.J. The Elastase-PK101 Structure: Mechanism of an Ultrasensitive Activity-based Probe Revealed. Acs Chem.Biol., 10:945-951, 2015 Cited by PubMed: 25581168DOI: 10.1021/cb500909n PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.63 Å) |
Structure validation
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