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4WVP

Crystal structure of an activity-based probe HNE complex

Summary for 4WVP
Entry DOI10.2210/pdb4wvp/pdb
Related PRD IDPRD_002139
DescriptorNeutrophil elastase, BTN-3V3-NLB-OMT-OIC-3V2, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
Functional Keywordsneutrophil elastase, acitivity-based probe, inhibitor, protease, complex, hne, hycosul, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains2
Total formula weight26429.16
Authors
Lechtenberg, B.C.,Kasperkiewicz, P.,Robinson, H.R.,Drag, M.,Riedl, S.J. (deposition date: 2014-11-06, release date: 2015-02-11, Last modification date: 2023-11-15)
Primary citationLechtenberg, B.C.,Kasperkiewicz, P.,Robinson, H.,Drag, M.,Riedl, S.J.
The Elastase-PK101 Structure: Mechanism of an Ultrasensitive Activity-based Probe Revealed.
Acs Chem.Biol., 10:945-951, 2015
Cited by
PubMed: 25581168
DOI: 10.1021/cb500909n
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.63 Å)
Structure validation

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