4WVP

Crystal structure of an activity-based probe HNE complex

Functional Information from GO Data

Chain	GOid	namespace	contents
E	0000122	biological_process	negative regulation of transcription by RNA polymerase II
E	0001878	biological_process	response to yeast
E	0002020	molecular_function	protease binding
E	0002438	biological_process	acute inflammatory response to antigenic stimulus
E	0002523	biological_process	leukocyte migration involved in inflammatory response
E	0002812	biological_process	biosynthetic process of antibacterial peptides active against Gram-negative bacteria
E	0003714	molecular_function	transcription corepressor activity
E	0004175	molecular_function	endopeptidase activity
E	0004252	molecular_function	serine-type endopeptidase activity
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006508	biological_process	proteolysis
E	0006874	biological_process	intracellular calcium ion homeostasis
E	0006909	biological_process	phagocytosis
E	0008201	molecular_function	heparin binding
E	0008233	molecular_function	peptidase activity
E	0008236	molecular_function	serine-type peptidase activity
E	0009411	biological_process	response to UV
E	0009986	cellular_component	cell surface
E	0017053	cellular_component	transcription repressor complex
E	0019955	molecular_function	cytokine binding
E	0022617	biological_process	extracellular matrix disassembly
E	0030141	cellular_component	secretory granule
E	0030163	biological_process	protein catabolic process
E	0031410	cellular_component	cytoplasmic vesicle
E	0032496	biological_process	response to lipopolysaccharide
E	0032682	biological_process	negative regulation of chemokine production
E	0032717	biological_process	negative regulation of interleukin-8 production
E	0032757	biological_process	positive regulation of interleukin-8 production
E	0035578	cellular_component	azurophil granule lumen
E	0035580	cellular_component	specific granule lumen
E	0042742	biological_process	defense response to bacterium
E	0043406	biological_process	positive regulation of MAP kinase activity
E	0045335	cellular_component	phagocytic vesicle
E	0048661	biological_process	positive regulation of smooth muscle cell proliferation
E	0050728	biological_process	negative regulation of inflammatory response
E	0050778	biological_process	positive regulation of immune response
E	0050832	biological_process	defense response to fungus
E	0050900	biological_process	leukocyte migration
E	0050922	biological_process	negative regulation of chemotaxis
E	0062023	cellular_component	collagen-containing extracellular matrix
E	0070062	cellular_component	extracellular exosome
E	0070269	biological_process	pyroptosis
E	0070945	biological_process	neutrophil-mediated killing of gram-negative bacterium
E	0070947	biological_process	neutrophil-mediated killing of fungus
E	1903238	biological_process	positive regulation of leukocyte tethering or rolling

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. MSAAHC

Chain	Residue	Details
E	MET53-CYS58

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site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. GVcfGDSGSPLV

Chain	Residue	Details
E	GLY189-VAL200

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Charge relay system => ECO:0000269|PubMed:2911584

Chain	Residue	Details
E	HIS57
E	ASP102
E	SER195

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site_id	SWS_FT_FI2
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218

Chain	Residue	Details
E	ASN72

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site_id	SWS_FT_FI3
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:26274980, ECO:0000269|PubMed:3550808

Chain	Residue	Details
E	ASN109

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site_id	SWS_FT_FI4
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:3550808

Chain	Residue	Details
E	ASN159

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