7KJA

Crystal structure of the EphA2 intracellular KD-SAM domains

Summary for 7KJA

Entry DOI	10.2210/pdb7kja/pdb
Descriptor	Ephrin type-A receptor 2, GLYCEROL, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (5 entities in total)
Functional Keywords	eph receptor, kinase, sam, allostery, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	89412.43
Authors	Lechtenberg, B.C.,Pasquale, E.B. (deposition date: 2020-10-26, release date: 2021-02-03, Last modification date: 2023-10-18)
Primary citation	Lechtenberg, B.C.,Gehring, M.P.,Light, T.P.,Horne, C.R.,Matsumoto, M.W.,Hristova, K.,Pasquale, E.B. Regulation of the EphA2 receptor intracellular region by phosphomimetic negative charges in the kinase-SAM linker. Nat Commun, 12:7047-7047, 2021 Cited by PubMed: 34857764 DOI: 10.1038/s41467-021-27343-z PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.75 Å)

Structure validation