3QG5
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7ZQY
| Chaetomium thermophilum Rad50 Zn hook | Descriptor: | DH domain-containing protein, ZINC ION | Authors: | Lammens, K, Rotheneder, M, Stakyte, K. | Deposit date: | 2022-05-03 | Release date: | 2022-12-28 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.51 Å) | Cite: | Cryo-EM structure of the Mre11-Rad50-Nbs1 complex reveals the molecular mechanism of scaffolding functions. Mol.Cell, 83, 2023
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7PPJ
| human SLFN5 | Descriptor: | Schlafen family member 5, ZINC ION | Authors: | Lammens, K, Metzner, F.J. | Deposit date: | 2021-09-14 | Release date: | 2022-01-26 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.44 Å) | Cite: | Structural and biochemical characterization of human Schlafen 5. Nucleic Acids Res., 50, 2022
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8S86
| human PLD3 homodimer structure | Descriptor: | 5'-3' exonuclease PLD3 | Authors: | Lammens, K. | Deposit date: | 2024-03-05 | Release date: | 2024-05-15 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Lysosomal endonuclease RNase T2 and PLD exonucleases cooperatively generate RNA ligands for TLR7 activation. Immunity, 57, 2024
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3QF7
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4W9M
| AMPPNP bound Rad50 in complex with dsDNA | Descriptor: | DNA (5'-D(*GP*GP*TP*CP*GP*GP*TP*CP*AP*CP*CP*GP*AP*CP*C)-3'), DNA (5'-D(*GP*GP*TP*CP*GP*GP*TP*GP*AP*CP*CP*GP*AP*CP*C)-3'), Exonuclease, ... | Authors: | Rojowska, A, Lammens, K. | Deposit date: | 2014-08-27 | Release date: | 2015-01-14 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structure of the Rad50 DNA double-strand break repair protein in complex with DNA. Embo J., 33, 2014
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2W4R
| Crystal structure of the regulatory domain of human LGP2 | Descriptor: | MERCURY (II) ION, PROBABLE ATP-DEPENDENT RNA HELICASE DHX58, SULFATE ION | Authors: | Pippig, D.A, Hellmuth, J.C, Cui, S, Kirchhofer, A, Lammens, K, Lammens, A, Schmidt, A, Rothenfusser, S, Hopfner, K.P. | Deposit date: | 2008-12-01 | Release date: | 2009-02-24 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | The Regulatory Domain of the Rig-I Family ATPase Lgp2 Senses Double-Stranded RNA. Nucleic Acids Res., 37, 2009
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7ZR1
| Chaetomium thermophilum Mre11-Rad50-Nbs1 complex bound to ATPyS (composite structure) | Descriptor: | DH domain-containing protein, Double-strand break repair protein, FHA domain-containing protein, ... | Authors: | Bartho, J.D, Rotheneder, M, Stakyte, K, Lammens, K, Hopfner, K.P. | Deposit date: | 2022-05-03 | Release date: | 2023-01-11 | Last modified: | 2023-12-13 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Cryo-EM structure of the Mre11-Rad50-Nbs1 complex reveals the molecular mechanism of scaffolding functions. Mol.Cell, 83, 2023
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7A08
| CryoEM Structure of cGAS Nucleosome complex | Descriptor: | Cyclic GMP-AMP synthase, Histone H2A type 1-C, Histone H2B type 1-C/E/F/G/I, ... | Authors: | Michalski, S, de Oliveira Mann, C.C, Witte, G, Bartho, J, Lammens, K, Hopfner, K.P. | Deposit date: | 2020-08-07 | Release date: | 2020-09-23 | Last modified: | 2021-02-10 | Method: | ELECTRON MICROSCOPY (3.11 Å) | Cite: | Structural basis for sequestration and autoinhibition of cGAS by chromatin. Nature, 587, 2020
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2QFD
| Crystal structure of the regulatory domain of human RIG-I with bound Hg | Descriptor: | MERCURY (II) ION, Probable ATP-dependent RNA helicase DDX58 | Authors: | Cui, S, Lammens, A, Lammens, K, Hopfner, K.P. | Deposit date: | 2007-06-27 | Release date: | 2008-02-12 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | The C-Terminal Regulatory Domain Is the RNA 5'-Triphosphate Sensor of RIG-I. Mol.Cell, 29, 2008
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2QFB
| Crystal structure of the regulatory domain of human RIG-I with bound Zn | Descriptor: | Probable ATP-dependent RNA helicase DDX58, ZINC ION | Authors: | Cui, S, Lammens, A, Lammens, K, Hopfner, K.P. | Deposit date: | 2007-06-27 | Release date: | 2008-02-12 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | The C-Terminal Regulatory Domain Is the RNA 5'-Triphosphate Sensor of RIG-I. Mol.Cell, 29, 2008
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7ZKE
| Mot1:TBP:DNA - pre-hydrolysis state | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA (36-MER), ... | Authors: | Woike, S, Eustermann, S, Jung, J, Wenzl, S.J, Hagemann, G, Bartho, J.D, Lammens, K, Butryn, A, Herzog, F, Hopfner, K.-P. | Deposit date: | 2022-04-12 | Release date: | 2023-04-26 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structural basis for TBP displacement from TATA box DNA by the Swi2/Snf2 ATPase Mot1. Nat.Struct.Mol.Biol., 30, 2023
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4YKE
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7Q3Z
| DNA/RNA binding protein | Descriptor: | SODIUM ION, Schlafen family member 5, ZINC ION | Authors: | Huber, E, Lammens, K. | Deposit date: | 2021-10-29 | Release date: | 2022-01-26 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structural and biochemical characterization of human Schlafen 5. Nucleic Acids Res., 50, 2022
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5DA9
| ATP-gamma-S bound Rad50 from Chaetomium thermophilum in complex with the Rad50-binding domain of Mre11 | Descriptor: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Putative double-strand break protein, ... | Authors: | Seifert, F.U, Lammens, K, Stoehr, G, Kessler, B, Hopfner, K.-P. | Deposit date: | 2015-08-19 | Release date: | 2016-03-02 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural mechanism of ATP-dependent DNA binding and DNA end bridging by eukaryotic Rad50. Embo J., 35, 2016
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5DAC
| ATP-gamma-S bound Rad50 from Chaetomium thermophilum in complex with DNA | Descriptor: | 4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE, DNA (5'-D(P*CP*CP*CP*CP*CP*CP*CP*CP*CP*CP*CP*CP*CP*CP*C)-3'), DNA (5'-D(P*GP*GP*GP*GP*GP*GP*GP*GP*GP*GP*GP*GP*GP*GP*G)-3'), ... | Authors: | Seifert, F.U, Lammens, K, Stoehr, G, Kessler, B, Hopfner, K.-P. | Deposit date: | 2015-08-19 | Release date: | 2016-03-02 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.503 Å) | Cite: | Structural mechanism of ATP-dependent DNA binding and DNA end bridging by eukaryotic Rad50. Embo J., 35, 2016
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8BAH
| Human Mre11-Nbs1 complex | Descriptor: | Double-strand break repair protein MRE11, MANGANESE (II) ION, Nibrin | Authors: | Bartho, J.D, Rotheneder, M, Stakyte, K, Lammens, K, Hopfner, K.P. | Deposit date: | 2022-10-11 | Release date: | 2023-01-11 | Last modified: | 2023-12-13 | Method: | ELECTRON MICROSCOPY (4.13 Å) | Cite: | Cryo-EM structure of the Mre11-Rad50-Nbs1 complex reveals the molecular mechanism of scaffolding functions. Mol.Cell, 83, 2023
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4FCX
| S.pombe Mre11 apoenzym | Descriptor: | DNA repair protein rad32, MANGANESE (II) ION | Authors: | Schiller, C.B, Lammens, K, Hopfner, K.P. | Deposit date: | 2012-05-25 | Release date: | 2012-06-20 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structure of Mre11-Nbs1 complex yields insights into ataxia-telangiectasia-like disease mutations and DNA damage signaling. Nat.Struct.Mol.Biol., 19, 2012
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4FBW
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4FBK
| Crystal structure of a covalently fused Nbs1-Mre11 complex with one manganese ion per active site | Descriptor: | DNA repair and telomere maintenance protein nbs1,DNA repair protein rad32 CHIMERIC PROTEIN, MANGANESE (II) ION, SULFATE ION | Authors: | Schiller, C.B, Lammens, K, Hopfner, K.P. | Deposit date: | 2012-05-23 | Release date: | 2012-06-20 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.379 Å) | Cite: | Structure of Mre11-Nbs1 complex yields insights into ataxia-telangiectasia-like disease mutations and DNA damage signaling. Nat.Struct.Mol.Biol., 19, 2012
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4FBQ
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2R8J
| Structure of the Eukaryotic DNA Polymerase eta in complex with 1,2-d(GpG)-cisplatin containing DNA | Descriptor: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, Cisplatin, ... | Authors: | Carell, T, Alt, A, Lammens, K. | Deposit date: | 2007-09-11 | Release date: | 2007-12-11 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Bypass of DNA lesions generated during anticancer treatment with cisplatin by DNA polymerase eta Science, 318, 2007
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2R8K
| Structure of the Eukaryotic DNA Polymerase eta in complex with 1,2-d(GpG)-cisplatin containing DNA | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 5'-D(*DGP*DTP*DGP*DGP*DTP*DGP*DAP*DGP*DC)-3', 5'-D(P*DGP*DGP*DCP*DTP*DCP*DAP*DCP*DCP*DAP*DC)-3', ... | Authors: | Carell, T, Alt, A, Lammens, K. | Deposit date: | 2007-09-11 | Release date: | 2007-12-11 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Bypass of DNA lesions generated during anticancer treatment with cisplatin by DNA polymerase eta Science, 318, 2007
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4I1R
| Human MALT1 (caspase-IG3) in complex with thioridazine | Descriptor: | 10-{2-[(2S)-1-methylpiperidin-2-yl]ethyl}-2-(methylsulfanyl)-10H-phenothiazine, Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Authors: | Schlauderer, F, Lammens, K, Hopfner, K.P. | Deposit date: | 2012-11-21 | Release date: | 2013-08-28 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural Analysis of Phenothiazine Derivatives as Allosteric Inhibitors of the MALT1 Paracaspase. Angew.Chem.Int.Ed.Engl., 52, 2013
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6S85
| Cutting state of the E. coli Mre11-Rad50 (SbcCD) head complex bound to ADP and dsDNA. | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DNA (31-MER), DNA (32-MER), ... | Authors: | Kaeshammer, L, Saathoff, J.H, Gut, F, Bartho, J, Alt, A, Kessler, B, Lammens, K, Hopfner, K.P. | Deposit date: | 2019-07-08 | Release date: | 2019-09-04 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Mechanism of DNA End Sensing and Processing by the Mre11-Rad50 Complex. Mol.Cell, 76, 2019
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