7A08
CryoEM Structure of cGAS Nucleosome complex
Summary for 7A08
Entry DOI | 10.2210/pdb7a08/pdb |
EMDB information | 11601 |
Descriptor | Cyclic GMP-AMP synthase, Nucleosomal DNA strand 1, Nucleosomal DNA strand 2, ... (8 entities in total) |
Functional Keywords | complex, immune protein, nuclear protein, transferase |
Biological source | Mus musculus (Mouse) More |
Total number of polymer chains | 11 |
Total formula weight | 242823.12 |
Authors | Michalski, S.,de Oliveira Mann, C.C.,Witte, G.,Bartho, J.,Lammens, K.,Hopfner, K.P. (deposition date: 2020-08-07, release date: 2020-09-23, Last modification date: 2021-02-10) |
Primary citation | Michalski, S.,de Oliveira Mann, C.C.,Stafford, C.A.,Witte, G.,Bartho, J.,Lammens, K.,Hornung, V.,Hopfner, K.P. Structural basis for sequestration and autoinhibition of cGAS by chromatin. Nature, 587:678-682, 2020 Cited by PubMed: 32911480DOI: 10.1038/s41586-020-2748-0 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.11 Å) |
Structure validation
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