7A08

CryoEM Structure of cGAS Nucleosome complex

Summary for 7A08

Entry DOI	10.2210/pdb7a08/pdb
EMDB information	11601
Descriptor	Cyclic GMP-AMP synthase, Nucleosomal DNA strand 1, Nucleosomal DNA strand 2, ... (8 entities in total)
Functional Keywords	complex, immune protein, nuclear protein, transferase
Biological source	Mus musculus (Mouse) More
Total number of polymer chains	11
Total formula weight	242823.12
Authors	Michalski, S.,de Oliveira Mann, C.C.,Witte, G.,Bartho, J.,Lammens, K.,Hopfner, K.P. (deposition date: 2020-08-07, release date: 2020-09-23, Last modification date: 2021-02-10)
Primary citation	Michalski, S.,de Oliveira Mann, C.C.,Stafford, C.A.,Witte, G.,Bartho, J.,Lammens, K.,Hornung, V.,Hopfner, K.P. Structural basis for sequestration and autoinhibition of cGAS by chromatin. Nature, 587:678-682, 2020 Cited by PubMed: 32911480 DOI: 10.1038/s41586-020-2748-0 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.11 Å)

Structure validation