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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7A08

CryoEM Structure of cGAS Nucleosome complex

Functional Information from GO Data
ChainGOidnamespacecontents
b0000786cellular_componentnucleosome
b0003677molecular_functionDNA binding
b0005515molecular_functionprotein binding
b0005634cellular_componentnucleus
b0005654cellular_componentnucleoplasm
b0005694cellular_componentchromosome
b0006325biological_processchromatin organization
b0008285biological_processnegative regulation of cell population proliferation
b0030527molecular_functionstructural constituent of chromatin
b0031507biological_processheterochromatin formation
b0046982molecular_functionprotein heterodimerization activity
b0070062cellular_componentextracellular exosome
c0000786cellular_componentnucleosome
c0002227biological_processinnate immune response in mucosa
c0003677molecular_functionDNA binding
c0005515molecular_functionprotein binding
c0005615cellular_componentextracellular space
c0005634cellular_componentnucleus
c0005654cellular_componentnucleoplasm
c0005694cellular_componentchromosome
c0006325biological_processchromatin organization
c0006334biological_processnucleosome assembly
c0019731biological_processantibacterial humoral response
c0030527molecular_functionstructural constituent of chromatin
c0042742biological_processdefense response to bacterium
c0042802molecular_functionidentical protein binding
c0046982molecular_functionprotein heterodimerization activity
c0050830biological_processdefense response to Gram-positive bacterium
c0061844biological_processantimicrobial humoral immune response mediated by antimicrobial peptide
c0070062cellular_componentextracellular exosome
d0000776cellular_componentkinetochore
d0000781cellular_componentchromosome, telomeric region
d0000786cellular_componentnucleosome
d0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
d0000979molecular_functionRNA polymerase II core promoter sequence-specific DNA binding
d0003677molecular_functionDNA binding
d0005515molecular_functionprotein binding
d0005576cellular_componentextracellular region
d0005634cellular_componentnucleus
d0005654cellular_componentnucleoplasm
d0005694cellular_componentchromosome
d0006334biological_processnucleosome assembly
d0007080biological_processmitotic metaphase chromosome alignment
d0030307biological_processpositive regulation of cell growth
d0030527molecular_functionstructural constituent of chromatin
d0031492molecular_functionnucleosomal DNA binding
d0031507biological_processheterochromatin formation
d0032200biological_processtelomere organization
d0032991cellular_componentprotein-containing complex
d0046982molecular_functionprotein heterodimerization activity
d0051382biological_processkinetochore assembly
d0070062cellular_componentextracellular exosome
e0000781cellular_componentchromosome, telomeric region
e0000786cellular_componentnucleosome
e0003677molecular_functionDNA binding
e0003723molecular_functionRNA binding
e0005515molecular_functionprotein binding
e0005576cellular_componentextracellular region
e0005634cellular_componentnucleus
e0005654cellular_componentnucleoplasm
e0005694cellular_componentchromosome
e0006325biological_processchromatin organization
e0006334biological_processnucleosome assembly
e0016020cellular_componentmembrane
e0030527molecular_functionstructural constituent of chromatin
e0032200biological_processtelomere organization
e0032991cellular_componentprotein-containing complex
e0045653biological_processnegative regulation of megakaryocyte differentiation
e0046982molecular_functionprotein heterodimerization activity
e0061644biological_processprotein localization to CENP-A containing chromatin
e0070062cellular_componentextracellular exosome
f0000786cellular_componentnucleosome
f0003677molecular_functionDNA binding
f0005515molecular_functionprotein binding
f0005634cellular_componentnucleus
f0005654cellular_componentnucleoplasm
f0005694cellular_componentchromosome
f0006325biological_processchromatin organization
f0008285biological_processnegative regulation of cell population proliferation
f0030527molecular_functionstructural constituent of chromatin
f0031507biological_processheterochromatin formation
f0046982molecular_functionprotein heterodimerization activity
f0070062cellular_componentextracellular exosome
g0000786cellular_componentnucleosome
g0002227biological_processinnate immune response in mucosa
g0003677molecular_functionDNA binding
g0005515molecular_functionprotein binding
g0005615cellular_componentextracellular space
g0005634cellular_componentnucleus
g0005654cellular_componentnucleoplasm
g0005694cellular_componentchromosome
g0006325biological_processchromatin organization
g0006334biological_processnucleosome assembly
g0019731biological_processantibacterial humoral response
g0030527molecular_functionstructural constituent of chromatin
g0042742biological_processdefense response to bacterium
g0042802molecular_functionidentical protein binding
g0046982molecular_functionprotein heterodimerization activity
g0050830biological_processdefense response to Gram-positive bacterium
g0061844biological_processantimicrobial humoral immune response mediated by antimicrobial peptide
g0070062cellular_componentextracellular exosome
h0000776cellular_componentkinetochore
h0000781cellular_componentchromosome, telomeric region
h0000786cellular_componentnucleosome
h0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
h0000979molecular_functionRNA polymerase II core promoter sequence-specific DNA binding
h0003677molecular_functionDNA binding
h0005515molecular_functionprotein binding
h0005576cellular_componentextracellular region
h0005634cellular_componentnucleus
h0005654cellular_componentnucleoplasm
h0005694cellular_componentchromosome
h0006334biological_processnucleosome assembly
h0007080biological_processmitotic metaphase chromosome alignment
h0030307biological_processpositive regulation of cell growth
h0030527molecular_functionstructural constituent of chromatin
h0031492molecular_functionnucleosomal DNA binding
h0031507biological_processheterochromatin formation
h0032200biological_processtelomere organization
h0032991cellular_componentprotein-containing complex
h0046982molecular_functionprotein heterodimerization activity
h0051382biological_processkinetochore assembly
h0070062cellular_componentextracellular exosome
i0000781cellular_componentchromosome, telomeric region
i0000786cellular_componentnucleosome
i0003677molecular_functionDNA binding
i0003723molecular_functionRNA binding
i0005515molecular_functionprotein binding
i0005576cellular_componentextracellular region
i0005634cellular_componentnucleus
i0005654cellular_componentnucleoplasm
i0005694cellular_componentchromosome
i0006325biological_processchromatin organization
i0006334biological_processnucleosome assembly
i0016020cellular_componentmembrane
i0030527molecular_functionstructural constituent of chromatin
i0032200biological_processtelomere organization
i0032991cellular_componentprotein-containing complex
i0045653biological_processnegative regulation of megakaryocyte differentiation
i0046982molecular_functionprotein heterodimerization activity
i0061644biological_processprotein localization to CENP-A containing chromatin
i0070062cellular_componentextracellular exosome
Functional Information from PROSITE/UniProt
site_idPS00046
Number of Residues7
DetailsHISTONE_H2A Histone H2A signature. AGLqFPV
ChainResidueDetails
bALA21-VAL27
site_idPS00047
Number of Residues5
DetailsHISTONE_H4 Histone H4 signature. GAKRH
ChainResidueDetails
eGLY14-HIS18
site_idPS00322
Number of Residues7
DetailsHISTONE_H3_1 Histone H3 signature 1. KAPRKQL
ChainResidueDetails
dLYS14-LEU20
site_idPS00357
Number of Residues23
DetailsHISTONE_H2B Histone H2B signature. REIQTavRlLLpGELaKHAVSEG
ChainResidueDetails
cARG92-GLY114
site_idPS00959
Number of Residues9
DetailsHISTONE_H3_2 Histone H3 signature 2. PFqRLVREI
ChainResidueDetails
dPRO66-ILE74
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues66
DetailsRegion: {"description":"DNA-binding","evidences":[{"source":"PubMed","id":"23647843","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28902841","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28963528","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5N6I","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues41
DetailsRegion: {"description":"Interaction with collided ribosomes","evidences":[{"source":"UniProtKB","id":"Q8N884","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues5
DetailsMotif: {"description":"Nuclear export signal","evidences":[{"source":"UniProtKB","id":"Q8N884","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues10
DetailsMotif: {"description":"Nuclear localization signal","evidences":[{"source":"UniProtKB","id":"Q8N884","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues18
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"23647843","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"24332030","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4LEZ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"23647843","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24332030","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24462292","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28902841","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28963528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32814054","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32911481","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32913000","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5N6I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XZB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XZE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XZG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6X59","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7BUJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7BUM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7BUQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7JO9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7JOA","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"23647843","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24332030","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24462292","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28902841","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28963528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32814054","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32911481","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32913000","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5N6I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XZB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XZE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XZG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XJD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7BUJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7BUM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7BUQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7JO9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7JOA","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"23647843","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24332030","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24462292","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28902841","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28963528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32814054","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32911480","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32911481","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32913000","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5N6I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XZB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XZE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XZG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6X5A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7BUJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7BUM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7BUQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7JO9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7JOA","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues1
DetailsSite: {"description":"Arginine-anchor","evidences":[{"source":"PubMed","id":"31808743","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32911480","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32911481","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32913000","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues1
DetailsSite: {"description":"Cleavage; by CASP3","evidences":[{"source":"UniProtKB","id":"Q8N884","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues1
DetailsModified residue: {"description":"N6-lactoyllysine","evidences":[{"source":"PubMed","id":"39322678","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues1
DetailsModified residue: {"description":"PolyADP-ribosyl glutamic acid","evidences":[{"source":"PubMed","id":"35460603","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q8N884","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues1
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q8N884","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues1
DetailsModified residue: {"description":"5-glutamyl polyglutamate","evidences":[{"source":"PubMed","id":"26829768","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine; by CDK1 and PKB","evidences":[{"source":"PubMed","id":"26440888","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32351706","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues1
DetailsModified residue: {"description":"5-glutamyl glutamate","evidences":[{"source":"PubMed","id":"26829768","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues3
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q8N884","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"32474700","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues1
DetailsModified residue: {"description":"N6-methyllysine","evidences":[{"source":"PubMed","id":"35210392","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues3
DetailsLipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"UniProtKB","id":"Q8N884","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues1
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)","evidences":[{"source":"PubMed","id":"27637147","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"27637147","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32457395","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues1
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"27637147","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32457395","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI26
Number of Residues1
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"29426904","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI27
Number of Residues1
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"UniProtKB","id":"Q8N884","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI28
Number of Residues1
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)","evidences":[{"source":"PubMed","id":"28095500","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI29
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"Q8N884","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI30
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"38418882","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI31
Number of Residues1
DetailsModified residue: {"description":"N6-(beta-hydroxybutyryl)lysine; alternate","evidences":[{"source":"PubMed","id":"27105115","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI32
Number of Residues2
DetailsModified residue: {"description":"N6-crotonyllysine; alternate","evidences":[{"source":"PubMed","id":"21925322","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI33
Number of Residues4
DetailsModified residue: {"description":"N6-(2-hydroxyisobutyryl)lysine","evidences":[{"source":"PubMed","id":"24681537","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI34
Number of Residues14
DetailsModified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"PubMed","id":"22389435","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI35
Number of Residues2
DetailsModified residue: {"description":"N5-methylglutamine","evidences":[{"source":"PubMed","id":"24352239","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI36
Number of Residues1
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"22713238","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22980979","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI37
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22713238","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22980979","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI38
Number of Residues2
DetailsModified residue: {"description":"PolyADP-ribosyl glutamic acid","evidences":[{"source":"UniProtKB","id":"Q64475","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI39
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine; by AMPK","evidences":[{"source":"UniProtKB","id":"Q6ZWY9","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI40
Number of Residues4
DetailsModified residue: {"description":"N6-lactoyllysine; alternate","evidences":[{"source":"PubMed","id":"31645732","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI41
Number of Residues4
DetailsModified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"16627869","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI42
Number of Residues2
DetailsModified residue: {"description":"N6-(2-hydroxyisobutyryl)lysine; alternate","evidences":[{"source":"PubMed","id":"24681537","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI43
Number of Residues2
DetailsModified residue: {"description":"Dimethylated arginine","evidences":[{"source":"UniProtKB","id":"Q96A08","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI44
Number of Residues4
DetailsModified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"UniProtKB","id":"Q96A08","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI45
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q00729","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI46
Number of Residues2
DetailsGlycosylation: {"description":"O-linked (GlcNAc) serine","evidences":[{"source":"PubMed","id":"22121020","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI47
Number of Residues1
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"21726816","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI48
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"16307923","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16627869","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16713563","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22121020","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI49
Number of Residues1
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"19783980","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI50
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20850016","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI51
Number of Residues2
DetailsModified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"16267050","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17194708","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI52
Number of Residues2
DetailsModified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"PubMed","id":"22389435","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29211711","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI53
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"20850016","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI54
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI55
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q71DI3","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI56
Number of Residues4
DetailsModified residue: {"description":"N6-glutaryllysine; alternate","evidences":[{"source":"PubMed","id":"31542297","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI57
Number of Residues2
DetailsModified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"PubMed","id":"22389435","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27436229","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI58
Number of Residues2
DetailsModified residue: {"description":"N6-propionyllysine; alternate","evidences":[{"source":"PubMed","id":"17267393","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI59
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine; by PAK2","evidences":[{"source":"PubMed","id":"21724829","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17081983","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI60
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI61
Number of Residues2
DetailsModified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P62806","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI62
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P62806","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI63
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI64
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1); alternate","evidences":[{"source":"PubMed","id":"30886146","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI65
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"19818714","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI66
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

247536

PDB entries from 2026-01-14

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