Author results

2VPJ
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CRYSTAL STRUCTURE OF THE KELCH DOMAIN OF HUMAN KLHL12
Descriptor:KELCH-LIKE PROTEIN 12, ACETATE ION
Authors:Keates, T., Pike, A.C.W., Bullock, A.N., Salah, E., Filippakopoulos, P., Roos, A.K., von Delft, F., Savitsky, P., Weigelt, J., Edwards, A., Arrowsmith, C.H., Bountra, C., Knapp, S.
Deposit date:2008-02-29
Release date:2008-03-18
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural Basis for Cul3 Assembly with the Btb-Kelch Family of E3 Ubiquitin Ligases.
J.Biol.Chem., 288, 2013
3PRY
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CRYSTAL STRUCTURE OF THE MIDDLE DOMAIN OF HUMAN HSP90-BETA REFINED AT 2.3 A RESOLUTION
Descriptor:Heat shock protein HSP 90-beta, SULFATE ION, GLYCEROL, ...
Authors:Chaikuad, A., Pilka, E., Sharpe, T.D., Cooper, C.D.O., Phillips, C., Berridge, G., Ayinampudi, V., Fedorov, O., Keates, T., Thangaratnarajah, C., Zimmermann, T., Vollmar, M., Yue, W.W., Che, K.H., Krojer, T., Muniz, J.R.C., von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Bullock, A., Structural Genomics Consortium (SGC)
Deposit date:2010-11-30
Release date:2010-12-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Crystal structure of the middle domain of human HSP90-beta refined at 2.3 A resolution
To be Published
3I3N
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CRYSTAL STRUCTURE OF THE BTB-BACK DOMAINS OF HUMAN KLHL11
Descriptor:Kelch-like protein 11, THIOCYANATE ION, CHLORIDE ION
Authors:Murray, J.W., Cooper, C.D.O., Krojer, T., Mahajan, P., Salah, E., Keates, T., Savitsky, P., Pike, A.C.W., Roos, A., Muniz, J., von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Knapp, S., Bullock, A., Structural Genomics Consortium (SGC)
Deposit date:2009-06-30
Release date:2009-08-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of the BTB-BACK domains of human KLHL11
To be Published
3K2J
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CRYSTAL STRUCTURE OF THE 3RD BROMODOMAIN OF HUMAN POLY-BROMODOMAIN CONTAINING PROTEIN 1 (PB1)
Descriptor:Protein polybromo-1, CHLORIDE ION, SULFATE ION
Authors:Filippakopoulos, P., Picaud, S., Keates, T., Chaikuad, A., Pike, A.C.W., Krojer, T., Sethi, R., von Delft, F., Arrowsmith, C.H., Edwards, A., Weigelt, J., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2009-09-30
Release date:2009-10-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structure of the 3rd Bromodomain of Human Poly-bromodomain containing protein 1 (PB1)
To be Published
3LXJ
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CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN AAA DOMAIN CONTAINING 2B (ATAD2B)
Descriptor:ATPase family AAA domain-containing protein 2B, ISOPROPYL ALCOHOL
Authors:Filippakopoulos, P., Keates, T., Picaud, S., Fedorov, O., Krojer, T., Vollmar, M., Muniz, J., Pike, A.C.W., von Delft, F., Arrowsmith, C.H., Edwards, A., Weigelt, J., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2010-02-25
Release date:2010-03-09
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Histone recognition and large-scale structural analysis of the human bromodomain family.
Cell(Cambridge,Mass.), 149, 2012
3MQM
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CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN ASH1L
Descriptor:Probable histone-lysine N-methyltransferase ASH1L
Authors:Filippakopoulos, P., Picaud, S., Keates, T., Felletar, I., Vollmar, M., Chaikuad, A., Krojer, T., Canning, P., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2010-04-28
Release date:2010-05-19
Last modified:2012-04-11
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:Histone recognition and large-scale structural analysis of the human bromodomain family.
Cell(Cambridge,Mass.), 149, 2012
3MTL
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CRYSTAL STRUCTURE OF THE PCTAIRE1 KINASE IN COMPLEX WITH INDIRUBIN E804
Descriptor:Cell division protein kinase 16, (2Z,3E)-2,3'-BIINDOLE-2',3(1H,1'H)-DIONE 3-{O-[(3R)-3,4-DIHYDROXYBUTYL]OXIME}
Authors:Krojer, T., Sharpe, T.D., Roos, A., Savitsky, P., Amos, A., Ayinampudi, V., Berridge, G., Fedorov, O., Keates, T., Phillips, C., Burgess-Brown, N., Zhang, Y., Pike, A.C.W., Muniz, J., Vollmar, M., Thangaratnarajah, C., Rellos, P., Ugochukwu, E., Filippakopoulos, P., Yue, W., Das, S., von Delft, F., Edwards, A., Arrowsmith, C.H., Weigelt, J., Bountra, C., Knapp, S., Bullock, A., Structural Genomics Consortium (SGC)
Deposit date:2010-04-30
Release date:2010-06-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of the PCTAIRE1 kinase in complex with Indirubin E804
to be published
3NR9
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STRUCTURE OF HUMAN CDC2-LIKE KINASE 2 (CLK2)
Descriptor:Dual specificity protein kinase CLK2, (5Z)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-ylmethyl)amino]-1,3-thiazol-4(5H)-one
Authors:Chaikuad, A., Savitsky, P., Krojer, T., Muniz, J.R.C., Filippakopoulos, P., Rellos, P., Keates, T., Fedorov, O., Pike, A.C.W., Eswaran, J., Berridge, G., Phillips, C., Zhang, Y., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2010-06-30
Release date:2010-08-25
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:Structure of human CDC2-like kinase 2 (CLK2)
To be Published
3Q2E
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CRYSTAL STRUCTURE OF THE SECOND BROMODOMAIN OF HUMAN BROMODOMAIN AND WD REPEAT-CONTAINING PROTEIN 1 ISOFORM A (WDR9)
Descriptor:Bromodomain and WD repeat-containing protein 1, ACETATE ION
Authors:Filippakopoulos, P., Felletar, I., Picaud, S., Keates, T., Krojer, T., Muniz, J., Gileadi, O., Von Delft, F., Arrowsmith, C.H., Edwards, A., Weigelt, J., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2010-12-20
Release date:2011-02-16
Last modified:2012-04-11
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Histone recognition and large-scale structural analysis of the human bromodomain family.
Cell(Cambridge,Mass.), 149, 2012
3RCW
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CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN BRD1
Descriptor:Bromodomain-containing protein 1, 1-methylpyrrolidin-2-one, ACETATE ION, ...
Authors:Filippakopoulos, P., Keates, T., Picaud, S., Felletar, I., Pike, A.C.W., Krojer, T., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2011-03-31
Release date:2011-06-01
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Histone recognition and large-scale structural analysis of the human bromodomain family.
Cell(Cambridge,Mass.), 149, 2012
3TLP
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CRYSTAL STRUCTURE OF THE FOURTH BROMODOMAIN OF HUMAN POLY-BROMODOMAIN CONTAINING PROTEIN 1 (PB1)
Descriptor:Protein polybromo-1, NICKEL (II) ION
Authors:Filippakopoulos, P., Felletar, I., Picaud, S., Keates, T., Muniz, J., Krojer, T., Allerston, C.K., Latwiel, S., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2011-08-30
Release date:2011-09-28
Last modified:2012-04-11
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Histone recognition and large-scale structural analysis of the human bromodomain family.
Cell(Cambridge,Mass.), 149, 2012
2OO1
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CRYSTAL STRUCTURE OF THE BROMO DOMAIN 2 OF HUMAN BROMODOMAIN CONTAINING PROTEIN 3 (BRD3)
Descriptor:Bromodomain-containing protein 3, SODIUM ION, 1,2-ETHANEDIOL, ...
Authors:Filippakopoulos, P., Bullock, A., Papagrigoriou, E., Keates, T., Cooper, C., Smee, C., Ugochukwu, E., Debreczeni, J., von Delft, F., Arrowsmith, C., Edwards, A., Weigelt, J., Sundstrom, M., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2007-01-25
Release date:2007-02-13
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Histone recognition and large-scale structural analysis of the human bromodomain family.
Cell(Cambridge,Mass.), 149, 2012
2OSS
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CRYSTAL STRUCTURE OF THE BROMO DOMAIN 1 IN HUMAN BROMODOMAIN CONTAINING PROTEIN 4 (BRD4)
Descriptor:Bromodomain-containing protein 4, 1,2-ETHANEDIOL
Authors:Filippakopoulos, P., Keates, T., Savitsky, P., Burgess, N., Pike, A.C.W., Ugochukwu, E., von Delft, F., Arrowsmith, C.H., Edwards, A., Weigelt, J., Sundstrom, M., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2007-02-06
Release date:2007-02-20
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Histone recognition and large-scale structural analysis of the human bromodomain family.
Cell(Cambridge,Mass.), 149, 2012
2OUO
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CRYSTAL STRUCTURE OF THE BROMO DOMAIN 2 IN HUMAN BROMODOMAIN CONTAINING PROTEIN 4 (BRD4)
Descriptor:Bromodomain-containing protein 4, 1,2-ETHANEDIOL
Authors:Filippakopoulos, P., Keates, T., Savitsky, P., Burgess, N., Ugochukwu, E., von Delft, F., Arrowsmith, C.H., Edwards, A., Weigelt, J., Sundstrom, M., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2007-02-12
Release date:2007-02-27
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Histone recognition and large-scale structural analysis of the human bromodomain family.
Cell(Cambridge,Mass.), 149, 2012
2RFJ
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CRYSTAL STRUCTURE OF THE BROMO DOMAIN 1 IN HUMAN BROMODOMAIN CONTAINING PROTEIN, TESTIS SPECIFIC (BRDT)
Descriptor:Bromodomain testis-specific protein
Authors:Filippakopoulos, P., Salah, E., Savitsky, P., Keates, T., Parizotto, E., Elkins, J., Pike, A.C.W., Ugochukwu, E., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Sundstrom, M., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2007-09-30
Release date:2007-10-23
Last modified:2012-04-11
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Histone recognition and large-scale structural analysis of the human bromodomain family.
Cell(Cambridge,Mass.), 149, 2012
3DAI
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CRYSTAL STRUCTURE OF THE BROMODOMAIN OF THE HUMAN ATAD2
Descriptor:ATPase family AAA domain-containing protein 2, SULFATE ION, CHLORIDE ION
Authors:Filippakopoulos, P., Keates, T., Picaud, S., Fedorov, O., Roos, A.K., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2008-05-29
Release date:2008-09-09
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Histone recognition and large-scale structural analysis of the human bromodomain family.
Cell(Cambridge,Mass.), 149, 2012
3GG3
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CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN PCAF
Descriptor:Histone acetyltransferase PCAF, CHLORIDE ION
Authors:Filippakopoulos, P., Keates, T., Picaud, S., Rehana, K., Fedorov, O., Ugochukwu, E., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2009-02-27
Release date:2009-03-17
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Histone recognition and large-scale structural analysis of the human bromodomain family.
Cell(Cambridge,Mass.), 149, 2012
3HME
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CRYSTAL STRUCTURE OF HUMAN BROMODOMAIN CONTAINING 9 ISOFORM 1 (BRD9)
Descriptor:Bromodomain-containing protein 9
Authors:Filippakopoulos, P., Eswaran, J., Keates, T., Picaud, S., Roos, A., Chaikuad, A., von Delft, F., Arrowsmith, C.H., Edwards, A., Weigelt, J., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2009-05-29
Release date:2009-06-23
Last modified:2012-04-11
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Histone recognition and large-scale structural analysis of the human bromodomain family.
Cell(Cambridge,Mass.), 149, 2012
3HMF
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CRYSTAL STRUCTURE OF THE SECOND BROMODOMAIN OF HUMAN POLY-BROMODOMAIN CONTAINING PROTEIN 1 (PB1)
Descriptor:Protein polybromo-1, ZINC ION, 1,2-ETHANEDIOL, ...
Authors:Filippakopoulos, P., Picaud, S., Keates, T., Muniz, J., von Delft, F., Arrowsmith, C.H., Edwards, A., Weigelt, J., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2009-05-29
Release date:2009-06-23
Last modified:2012-04-11
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Histone recognition and large-scale structural analysis of the human bromodomain family.
Cell(Cambridge,Mass.), 149, 2012
3HMH
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CRYSTAL STRUCTURE OF THE SECOND BROMODOMAIN OF HUMAN TBP-ASSOCIATED FACTOR RNA POLYMERASE 1-LIKE (TAF1L)
Descriptor:Transcription initiation factor TFIID 210 kDa subunit
Authors:Filippakopoulos, P., Picaud, S., Keates, T., Zhang, Y., Pike, A.C.W., von Delft, F., Arrowsmith, C.H., Edwards, A., Weigelt, J., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2009-05-29
Release date:2009-06-23
Last modified:2012-04-11
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Histone recognition and large-scale structural analysis of the human bromodomain family.
Cell(Cambridge,Mass.), 149, 2012
3IU5
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CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN POLY-BROMODOMAIN CONTAINING PROTEIN 1 (PB1)
Descriptor:Protein polybromo-1
Authors:Filippakopoulos, P., Picaud, S., Keates, T., Ugochukwu, E., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2009-08-30
Release date:2009-09-22
Last modified:2012-04-11
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Histone recognition and large-scale structural analysis of the human bromodomain family.
Cell(Cambridge,Mass.), 149, 2012
3IU6
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CRYSTAL STRUCTURE OF THE SIXTH BROMODOMAIN OF HUMAN POLY-BROMODOMAIN CONTAINING PROTEIN 1 (PB1)
Descriptor:Protein polybromo-1, 1,2-ETHANEDIOL, ZINC ION
Authors:Filippakopoulos, P., Keates, T., Picaud, S., Pike, A.C.W., Ugochukwu, E., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2009-08-30
Release date:2009-09-22
Last modified:2012-04-11
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Histone recognition and large-scale structural analysis of the human bromodomain family.
Cell(Cambridge,Mass.), 149, 2012
3MB3
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CRYSTAL STRUCTURE OF THE SECOND BROMODOMAIN OF PLECKSTRIN HOMOLOGY DOMAIN INTERACTING PROTEIN (PHIP)
Descriptor:PH-interacting protein, 1-methylpyrrolidin-2-one
Authors:Filippakopoulos, P., Picaud, S., Keates, T., Ugochukwu, E., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2010-03-25
Release date:2010-04-14
Last modified:2012-04-11
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Histone recognition and large-scale structural analysis of the human bromodomain family.
Cell(Cambridge,Mass.), 149, 2012
3MB4
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CRYSTAL STRUCTURE OF THE FIFTH BROMODOMAIN OF HUMAN POLY-BROMODOMAIN CONTAINING PROTEIN 1 (PB1) WITH NMP
Descriptor:Protein polybromo-1, 1,2-ETHANEDIOL, 1-methylpyrrolidin-2-one, ...
Authors:Filippakopoulos, P., Picaud, S., Keates, T., Ugochukwu, E., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2010-03-25
Release date:2010-04-14
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Histone recognition and large-scale structural analysis of the human bromodomain family.
Cell(Cambridge,Mass.), 149, 2012
3NXB
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CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN CECR2
Descriptor:Cat eye syndrome critical region protein 2, 1,2-ETHANEDIOL
Authors:Filippakopoulos, P., Picaud, S., Keates, T., Muniz, J., von Delft, F., Arrowsmith, C.H., Edwards, A., Weigelt, J., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2010-07-13
Release date:2010-08-18
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Histone recognition and large-scale structural analysis of the human bromodomain family.
Cell(Cambridge,Mass.), 149, 2012