2VPJ

Crystal structure of the Kelch domain of human KLHL12

Summary for 2VPJ

Entry DOI	10.2210/pdb2vpj/pdb
Descriptor	KELCH-LIKE PROTEIN 12, ACETATE ION (3 entities in total)
Functional Keywords	adaptor protein, wnt signaling pathway, protein-binding, ubiquitin degradation, ubl conjugation pathway, cul3, kelch repeat, phosphoprotein, wnt signalling, protein binding
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cytoplasmic vesicle, COPII-coated vesicle : Q53G59
Total number of polymer chains	1
Total formula weight	33023.97
Authors	Keates, T.,Pike, A.C.W.,Bullock, A.N.,Salah, E.,Filippakopoulos, P.,Roos, A.K.,von Delft, F.,Savitsky, P.,Weigelt, J.,Edwards, A.,Arrowsmith, C.H.,Bountra, C.,Knapp, S. (deposition date: 2008-02-29, release date: 2008-03-18, Last modification date: 2023-12-13)
Primary citation	Canning, P.,Cooper, C.D.O.,Krojer, T.,Murray, J.W.,Pike, A.C.W.,Chaikuad, A.,Keates, T.,Thangaratnarajah, C.,Hojzan, V.,Marsden, B.D.,Gileadi, O.,Knapp, S.,von Delft, F.,Bullock, A.N. Structural Basis for Cul3 Assembly with the Btb-Kelch Family of E3 Ubiquitin Ligases. J.Biol.Chem., 288:7803-, 2013 Cited by PubMed: 23349464 DOI: 10.1074/JBC.M112.437996 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation