3UW9

Crystal Structure of the first bromodomain of human BRD4 in complex with a diacetylated histone 4 peptide (H4K8acK12ac)

Summary for 3UW9

Entry DOI	10.2210/pdb3uw9/pdb
Descriptor	Bromodomain-containing protein 4, histone 4 peptide (H4K8acK12ac) (3 entities in total)
Functional Keywords	bromodomain, bromodomain containing protein 4, cap, hunk1, mcap, mitotic chromosome associated protein, peptide complex, structural genomics consortium, sgc, protein binding
Biological source	Homo sapiens (human) More
Cellular location	Nucleus (By similarity): O60885 Nucleus: P62805
Total number of polymer chains	6
Total formula weight	62626.12
Authors	Filippakopoulos, P.,Felletar, I.,Picaud, S.,Keates, T.,Muniz, J.,Gileadi, O.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Weigelt, J.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2011-12-01, release date: 2012-03-14, Last modification date: 2024-04-03)
Primary citation	Filippakopoulos, P.,Picaud, S.,Mangos, M.,Keates, T.,Lambert, J.P.,Barsyte-Lovejoy, D.,Felletar, I.,Volkmer, R.,Muller, S.,Pawson, T.,Gingras, A.C.,Arrowsmith, C.H.,Knapp, S. Histone recognition and large-scale structural analysis of the human bromodomain family. Cell(Cambridge,Mass.), 149:214-231, 2012 Cited by PubMed: 22464331 DOI: 10.1016/j.cell.2012.02.013 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation