3UVD

Crystal Structure of the bromodomain of human Transcription activator BRG1 (SMARCA4) in complex with N-Methyl-2-pyrrolidone

Summary for 3UVD

Entry DOI	10.2210/pdb3uvd/pdb
Related	3UV2 3UV4 3UV5 3UVW 3UVX 3UVY 3UW9
Descriptor	Transcription activator BRG1, 1-methylpyrrolidin-2-one (3 entities in total)
Functional Keywords	bromodomain, atp-dependent helicase smarca4, brg1-associated factor 190a, baf190a, mitotic growth and transcription activator, protein brg-1, protein brahma homolog 1, snf2-beta, swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily a member 4, structural genomics consortium, sgc, transcription
Biological source	Homo sapiens (human)
Cellular location	Nucleus: P51532
Total number of polymer chains	1
Total formula weight	14658.95
Authors	Filippakopoulos, P.,Felletar, I.,Picaud, S.,Keates, T.,Muniz, J.,Gileadi, O.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Weigelt, J.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2011-11-29, release date: 2012-01-18, Last modification date: 2023-09-13)
Primary citation	Filippakopoulos, P.,Picaud, S.,Mangos, M.,Keates, T.,Lambert, J.P.,Barsyte-Lovejoy, D.,Felletar, I.,Volkmer, R.,Muller, S.,Pawson, T.,Gingras, A.C.,Arrowsmith, C.H.,Knapp, S. Histone recognition and large-scale structural analysis of the human bromodomain family. Cell(Cambridge,Mass.), 149:214-231, 2012 Cited by PubMed: 22464331 DOI: 10.1016/j.cell.2012.02.013 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation