3UVX

Crystal Structure of the first bromodomain of human BRD4 in complex with a diacetylated histone 4 peptide (H4K12acK16ac)

Summary for 3UVX

Entry DOI	10.2210/pdb3uvx/pdb
Descriptor	Bromodomain-containing protein 4, diacetylated histone 4 peptide, SODIUM ION, ... (6 entities in total)
Functional Keywords	bromodomain, bromodomain containing protein 4, cap, hunk1, mcap, mitotic chromosome associated protein, peptide complex, structural genomics consortium, sgc, transcription-protein binding complex, transcription/protein binding
Biological source	Homo sapiens (human) More
Cellular location	Nucleus: O60885
Total number of polymer chains	2
Total formula weight	16627.01
Authors	Filippakopoulos, P.,Picaud, S.,Keates, T.,Ugochukwu, E.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Weigelt, J.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2011-11-30, release date: 2012-01-25, Last modification date: 2023-12-06)
Primary citation	Filippakopoulos, P.,Picaud, S.,Mangos, M.,Keates, T.,Lambert, J.P.,Barsyte-Lovejoy, D.,Felletar, I.,Volkmer, R.,Muller, S.,Pawson, T.,Gingras, A.C.,Arrowsmith, C.H.,Knapp, S. Histone recognition and large-scale structural analysis of the human bromodomain family. Cell(Cambridge,Mass.), 149:214-231, 2012 Cited by PubMed: 22464331 DOI: 10.1016/j.cell.2012.02.013 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.91 Å)

Structure validation