3UVX
Crystal Structure of the first bromodomain of human BRD4 in complex with a diacetylated histone 4 peptide (H4K12acK16ac)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Bromodomain-containing protein 4 | polymer | 127 | 15099.4 | 1 | UniProt (O60885) Pfam (PF00439) In PDB | Homo sapiens (human) | Protein HUNK1 |
| 2 | B | diacetylated histone 4 peptide | polymer | 11 | 1281.5 | 1 | UniProt (by SIFTS) (P62805) In PDB | homo sapiens | Peptide (H4K12acK16ac) |
| 3 | A | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 4 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 5 | A | FORMIC ACID | non-polymer | 46.0 | 3 | Chemie (FMT) | |||
| 6 | water | water | 18.0 | 99 | Chemie (HOH) |
Sequence modifications
A: 44 - 168 (UniProt: O60885)
| PDB | External Database | Details |
|---|---|---|
| Ser 42 | - | expression tag |
| Met 43 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 16380.9 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 246.1 | |
| All* | Total formula weight | 16627.0 |
