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3UVX

Crystal Structure of the first bromodomain of human BRD4 in complex with a diacetylated histone 4 peptide (H4K12acK16ac)

Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE NA A 1
ChainResidue
AHOH30
AASN61
AGLN64
ATYR137
AASN140

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE NA A 2
ChainResidue
AGLU49
AHOH202
AHOH203
AHOH231

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE EDO A 169
ChainResidue
AILE100
AILE101
ALYS102
ATHR103
AASN135
AHOH226

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE FMT A 170
ChainResidue
ATHR60
AGLN62
AASN121
AALA122
AHOH231

site_idAC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE FMT A 171
ChainResidue
AHOH8
ASER51
AASN52
ALYS57
AASN116
ATYR118

site_idAC6
Number of Residues2
DetailsBINDING SITE FOR RESIDUE FMT A 3
ChainResidue
AARG113
AASP128

Functional Information from PROSITE/UniProt
site_idPS00047
Number of Residues5
DetailsHISTONE_H4 Histone H4 signature. GAKRH
ChainResidueDetails
BGLY14-HIS18

site_idPS00633
Number of Residues60
DetailsBROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY
ChainResidueDetails
AALA80-TYR139

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues106
DetailsDomain: {"description":"Bromo 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00035","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues1
DetailsSite: {"description":"Acetylated histone binding","evidences":[{"source":"PubMed","id":"22464331","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

239803

PDB entries from 2025-08-06

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