3UVX

Crystal Structure of the first bromodomain of human BRD4 in complex with a diacetylated histone 4 peptide (H4K12acK16ac)

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA A 1

Chain	Residue
A	HOH30
A	ASN61
A	GLN64
A	TYR137
A	ASN140

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA A 2

Chain	Residue
A	GLU49
A	HOH202
A	HOH203
A	HOH231

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 169

Chain	Residue
A	ILE100
A	ILE101
A	LYS102
A	THR103
A	ASN135
A	HOH226

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FMT A 170

Chain	Residue
A	THR60
A	GLN62
A	ASN121
A	ALA122
A	HOH231

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FMT A 171

Chain	Residue
A	HOH8
A	SER51
A	ASN52
A	LYS57
A	ASN116
A	TYR118

---

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE FMT A 3

Chain	Residue
A	ARG113
A	ASP128

---

Functional Information from PROSITE/UniProt

site_id	PS00047
Number of Residues	5
Details	HISTONE_H4 Histone H4 signature. GAKRH

Chain	Residue	Details
B	GLY14-HIS18

---

site_id	PS00633
Number of Residues	60
Details	BROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY

Chain	Residue	Details
A	ALA80-TYR139

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	DNA_BIND:

Chain	Residue	Details
B	ALY16-LYS20

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000269|PubMed:22389435

Chain	Residue	Details
B	ALY12

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: N6-propionyllysine; alternate => ECO:0000269|PubMed:17267393

Chain	Residue	Details
B	ALY16

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:12086618, ECO:0000269|PubMed:15964846, ECO:0000269|PubMed:17967882, ECO:0000269|PubMed:27338793

Chain	Residue	Details
B	LYS20

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25218447

Chain	Residue	Details
B	ALY12

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733

Chain	Residue	Details
B	LYS20

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