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4PED
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BU of 4ped by Molmil
Mitochondrial ADCK3 employs an atypical protein kinase-like fold to enable coenzyme Q biosynthes
Descriptor: Chaperone activity of bc1 complex-like, mitochondrial, SULFATE ION
Authors:Bingman, C.A, Smith, R, Joshi, S, Stefely, J.A, Reidenbach, A.G, Ulbrich, A, Oruganty, O, Floyd, B.J, Jochem, A, Saunders, J.M, Johnson, I.E, Wrobel, R.L, Barber, G.E, Lee, D, Li, S, Kannan, N, Coon, J.J, Pagliarini, D.J, Mitochondrial Protein Partnership (MPP)
Deposit date:2014-04-22
Release date:2014-11-19
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Mitochondrial ADCK3 Employs an Atypical Protein Kinase-like Fold to Enable Coenzyme Q Biosynthesis.
Mol.Cell, 57, 2015
6P5S
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BU of 6p5s by Molmil
HIPK2 kinase domain bound to CX-4945
Descriptor: 5-[(3-chlorophenyl)amino]benzo[c][2,6]naphthyridine-8-carboxylic acid, Homeodomain-interacting protein kinase 2
Authors:Agnew, C, Liu, L, Jura, N.
Deposit date:2019-05-30
Release date:2019-07-31
Last modified:2019-09-25
Method:X-RAY DIFFRACTION (2.194 Å)
Cite:The crystal structure of the protein kinase HIPK2 reveals a unique architecture of its CMGC-insert region.
J.Biol.Chem., 294, 2019
6VVG
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BU of 6vvg by Molmil
Structure of the Cydia pomonella Granulovirus kinase, PK-1
Descriptor: ADENOSINE MONOPHOSPHATE, Arginine kinase
Authors:Oliver, M.R, Horne, C.R, Keown, J.R, Murphy, J.M, Metcalf, P.
Deposit date:2020-02-17
Release date:2021-02-03
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Granulovirus PK-1 kinase activity relies on a side-to-side dimerization mode centered on the regulatory alpha C helix.
Nat Commun, 12, 2021
7AKG
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BU of 7akg by Molmil
Crystal structure of STK17B with bound dovitinib
Descriptor: 1,2-ETHANEDIOL, 4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one, Serine/threonine-protein kinase 17B
Authors:Chaikuad, A, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2020-09-30
Release date:2020-12-02
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:A Chemical Probe for Dark Kinase STK17B Derives Its Potency and High Selectivity through a Unique P-Loop Conformation.
J.Med.Chem., 63, 2020
1SYK
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BU of 1syk by Molmil
Crystal structure of E230Q mutant of cAMP-dependent protein kinase reveals unexpected apoenzyme conformation
Descriptor: cAMP-dependent protein kinase, alpha-catalytic subunit
Authors:Wu, J, Yang, J, Madhusudan, N, Xuong, N.H, Ten Eyck, L.F, Taylor, S.S.
Deposit date:2004-04-01
Release date:2005-05-17
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of the E230Q mutant of cAMP-dependent protein kinase reveals an unexpected apoenzyme conformation and an extended N-terminal A helix.
Protein Sci., 14, 2005
7OTE
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BU of 7ote by Molmil
Src Kinase Domain in complex with ponatinib
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide, GLYCEROL, ...
Authors:Soriano-Maldonado, P, Cuesta-Hernandez, H.N, Plaza-Menacho, I.
Deposit date:2021-06-10
Release date:2022-06-22
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:An allosteric switch between the activation loop and a c-terminal palindromic phospho-motif controls c-Src function.
Nat Commun, 14, 2023
6OID
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BU of 6oid by Molmil
Redox Regulation of FN3K from Arabidopsis thaliana
Descriptor: 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ...
Authors:Wood, Z.A, Kadirvelraj, R, Shrestha, S.
Deposit date:2019-04-09
Release date:2020-05-20
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.365 Å)
Cite:A redox-active switch in fructosamine-3-kinases expands the regulatory repertoire of the protein kinase superfamily.
Sci.Signal., 13, 2020
6OM8
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BU of 6om8 by Molmil
Caenorhabditis Elegans UDP-Glucose Dehydrogenase in complex with UDP-Xylose
Descriptor: UDP-glucose 6-dehydrogenase, URIDINE-5'-DIPHOSPHATE-XYLOPYRANOSE
Authors:Beattie, N.R, McDonald, W.E, Hicks Sirmans, T.N, Wood, Z.A.
Deposit date:2019-04-18
Release date:2019-05-22
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.449 Å)
Cite:Conservation of Atypical Allostery inC. elegansUDP-Glucose Dehydrogenase.
Acs Omega, 4, 2019
6DC0
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BU of 6dc0 by Molmil
Tribbles (TRIB1) pseudokinase fused to CCAAT-enhancer binding protein (C/EBPalpha) degron
Descriptor: Tribbles homolog 1,CCAAT/enhancer-binding protein alpha
Authors:Jamieson, S.A, Brewster, J.L, Mace, P.D.
Deposit date:2018-05-03
Release date:2018-10-10
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Substrate binding allosterically relieves autoinhibition of the pseudokinase TRIB1.
Sci Signal, 11, 2018
8D3Z
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BU of 8d3z by Molmil
Crystal structure of GalS1 in complex with Manganese from Populus trichocarpas
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Galactan synthase, ...
Authors:Pereira, J.H, Prabhakar, P.K, Urbanowicz, B.R, Adams, P.D.
Deposit date:2022-06-01
Release date:2023-03-15
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Structural and biochemical insight into a modular beta-1,4-galactan synthase in plants.
Nat.Plants, 9, 2023
8D3T
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BU of 8d3t by Molmil
Crystal structure of GalS1 from Populus trichocarpas
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Pereira, J.H, Prabhakar, P.K, Urbanowicz, B.R, Adams, P.D.
Deposit date:2022-06-01
Release date:2023-03-15
Last modified:2023-04-05
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Structural and biochemical insight into a modular beta-1,4-galactan synthase in plants.
Nat.Plants, 9, 2023
5I35
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BU of 5i35 by Molmil
Structure of the Human mitochondrial kinase COQ8A R611K with AMPPNP (Cerebellar Ataxia and Ubiquinone Deficiency Through Loss of Unorthodox Kinase Activity)
Descriptor: Atypical kinase ADCK3, mitochondrial, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Bingman, C.A, Stefely, J.A, Pagliarini, D.J, Mitochondrial Protein Partnership (MPP)
Deposit date:2016-02-09
Release date:2016-08-17
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Cerebellar Ataxia and Coenzyme Q Deficiency through Loss of Unorthodox Kinase Activity.
Mol.Cell, 63, 2016
6Y6H
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BU of 6y6h by Molmil
Crystal structure of STK17b (DRAK2) in complex with UNC-AP-194 probe
Descriptor: 1,2-ETHANEDIOL, 2-[6-(1-benzothiophen-2-yl)thieno[3,2-d]pyrimidin-4-yl]sulfanylethanoic acid, Serine/threonine-protein kinase 17B
Authors:Chaikuad, A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Drewry, D, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2020-02-26
Release date:2020-03-11
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:A Chemical Probe for Dark Kinase STK17B Derives Its Potency and High Selectivity through a Unique P-Loop Conformation.
J.Med.Chem., 63, 2020
6Y6F
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BU of 6y6f by Molmil
Crystal structure of STK17B (DRAK2) in complex with PKIS43
Descriptor: 1,2-ETHANEDIOL, 2-[6-(4-methylsulfanylphenyl)thieno[3,2-d]pyrimidin-4-yl]sulfanylethanoic acid, Serine/threonine-protein kinase 17B
Authors:Chaikuad, A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Drewry, D, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2020-02-26
Release date:2020-03-11
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:A Chemical Probe for Dark Kinase STK17B Derives Its Potency and High Selectivity through a Unique P-Loop Conformation.
J.Med.Chem., 63, 2020
6ZJF
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BU of 6zjf by Molmil
Crystal structure of STK17B (DRAK2) in complex with AP-229
Descriptor: 1,2-ETHANEDIOL, 2-[6-(4-cyclopropylphenyl)thieno[3,2-d]pyrimidin-4-yl]sulfanylethanoic acid, Serine/threonine-protein kinase 17B
Authors:Chaikuad, A, Picado, A, Willson, T, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2020-06-28
Release date:2020-07-29
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:A Chemical Probe for Dark Kinase STK17B Derives Its Potency and High Selectivity through a Unique P-Loop Conformation.
J.Med.Chem., 63, 2020
6TSZ
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BU of 6tsz by Molmil
The ULK4 Pseudokinase Domain Bound To ATPgammaS
Descriptor: PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase ULK4
Authors:Preuss, F, Chatterjee, D, Mathea, S, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Knapp, S.
Deposit date:2019-12-22
Release date:2020-01-01
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Nucleotide Binding, Evolutionary Insights, and Interaction Partners of the Pseudokinase Unc-51-like Kinase 4.
Structure, 28, 2020
8SLZ
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BU of 8slz by Molmil
Crystal structure of phosphorylated (T357/S358) human MLKL pseudokinase domain
Descriptor: Mixed lineage kinase domain-like protein
Authors:Meng, Y, Davies, K.A, Czabotar, P.E, Murphy, J.M.
Deposit date:2023-04-25
Release date:2023-11-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Phosphorylation-dependent pseudokinase domain dimerization drives full-length MLKL oligomerization.
Nat Commun, 14, 2023
6VBZ
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BU of 6vbz by Molmil
Crystal structure of the rat MLKL pseudokinase domain
Descriptor: MANGANESE (II) ION, Mixed lineage kinase domain-like pseudokinase
Authors:Davies, K.A, Czabotar, P.E.
Deposit date:2019-12-19
Release date:2020-07-08
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.192 Å)
Cite:Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues.
Nat Commun, 11, 2020
6VC0
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BU of 6vc0 by Molmil
Crystal structure of the horse MLKL pseudokinase domain
Descriptor: GLYCEROL, Mixed lineage kinase domain like pseudokinase
Authors:Davies, K.A, Czabotar, P.E.
Deposit date:2019-12-19
Release date:2020-07-08
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.746 Å)
Cite:Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues.
Nat Commun, 11, 2020
3LM5
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BU of 3lm5 by Molmil
Crystal Structure of human Serine/Threonine Kinase 17B (STK17B) in complex with Quercetin
Descriptor: 3,5,7,3',4'-PENTAHYDROXYFLAVONE, Serine/threonine-protein kinase 17B
Authors:Ugochukwu, E, Soundararajan, M, Rellos, P, Fedorov, O, Phillips, C, Wang, J, Hapka, E, Filippakopoulos, P, Chaikuad, A, Pike, A.C.W, Carpenter, L, Vollmar, M, von Delft, F, Bountra, C, Arrowsmith, C.H, Weigelt, J, Edwards, A, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2010-01-29
Release date:2010-03-16
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:A Chemical Probe for Dark Kinase STK17B Derives Its Potency and High Selectivity through a Unique P-Loop Conformation.
J.Med.Chem., 63, 2020
7JW7
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BU of 7jw7 by Molmil
Structure of monobody 27 human MLKL pseudokinase domain complex
Descriptor: Mixed lineage kinase domain-like protein, Monobody 27
Authors:Meng, Y, Garnish, S.E, Koide, A, Koide, S, Czabotar, P.E, Murphy, J.M.
Deposit date:2020-08-25
Release date:2021-03-10
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.63 Å)
Cite:Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis.
Nat Commun, 12, 2021
7JXU
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BU of 7jxu by Molmil
Structure of monobody 32 human MLKL pseudokinase domain complex
Descriptor: 1,2-ETHANEDIOL, Mixed lineage kinase domain-like protein, Monobody 32
Authors:Meng, Y, Garnish, S.E, Koide, A, Koide, S, Czabotar, P.E, Murphy, J.M.
Deposit date:2020-08-28
Release date:2021-03-10
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis.
Nat Commun, 12, 2021
3FJQ
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BU of 3fjq by Molmil
Crystal structure of cAMP-dependent protein kinase catalytic subunit alpha in complex with peptide inhibitor PKI alpha (6-25)
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, cAMP-dependent protein kinase catalytic subunit alpha, ...
Authors:Kim, C.
Deposit date:2008-12-15
Release date:2009-08-04
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Comparative surface geometry of the protein kinase family.
Protein Sci., 18, 2009

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