7JXU

Structure of monobody 32 human MLKL pseudokinase domain complex

Summary for 7JXU

• Entry DOI: 10.2210/pdb7jxu/pdb
• Related: 7JW7
• Descriptor: Mixed lineage kinase domain-like protein, Monobody 32, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: pseudokinase, monobody, complex, necroptosis, transferase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 87503.95

Authors

Meng, Y.,Garnish, S.E.,Koide, A.,Koide, S.,Czabotar, P.E.,Murphy, J.M. (deposition date: 2020-08-28, release date: 2021-03-10, Last modification date: 2023-10-18)

• Primary citation: Garnish, S.E.,Meng, Y.,Koide, A.,Sandow, J.J.,Denbaum, E.,Jacobsen, A.V.,Yeung, W.,Samson, A.L.,Horne, C.R.,Fitzgibbon, C.,Young, S.N.,Smith, P.P.C.,Webb, A.I.,Petrie, E.J.,Hildebrand, J.M.,Kannan, N.,Czabotar, P.E.,Koide, S.,Murphy, J.M.; Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis.; Nat Commun, 12:2211-2211, 2021; PubMed: 33850121; DOI: 10.1038/s41467-021-22400-z

Experimental method

X-RAY DIFFRACTION (2.44 Å)