6DC0
Tribbles (TRIB1) pseudokinase fused to CCAAT-enhancer binding protein (C/EBPalpha) degron
Summary for 6DC0
| Entry DOI | 10.2210/pdb6dc0/pdb |
| Descriptor | Tribbles homolog 1,CCAAT/enhancer-binding protein alpha (2 entities in total) |
| Functional Keywords | tribbles, psuedokinase, ccaat-enhancer binding protein, trb1, signaling protein |
| Biological source | Homo sapiens (Human) More |
| Total number of polymer chains | 2 |
| Total formula weight | 65618.95 |
| Authors | Jamieson, S.A.,Brewster, J.L.,Mace, P.D. (deposition date: 2018-05-03, release date: 2018-10-10, Last modification date: 2023-10-04) |
| Primary citation | Jamieson, S.A.,Ruan, Z.,Burgess, A.E.,Curry, J.R.,McMillan, H.D.,Brewster, J.L.,Dunbier, A.K.,Axtman, A.D.,Kannan, N.,Mace, P.D. Substrate binding allosterically relieves autoinhibition of the pseudokinase TRIB1. Sci Signal, 11:-, 2018 Cited by PubMed: 30254053DOI: 10.1126/scisignal.aau0597 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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