6ZJF
Crystal structure of STK17B (DRAK2) in complex with AP-229
Summary for 6ZJF
Entry DOI | 10.2210/pdb6zjf/pdb |
Descriptor | Serine/threonine-protein kinase 17B, 2-[6-(4-cyclopropylphenyl)thieno[3,2-d]pyrimidin-4-yl]sulfanylethanoic acid, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | kinase inhibitor, drak2, stk17b, structural genomics, structural genomics consortium, sgc, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 37793.66 |
Authors | Chaikuad, A.,Picado, A.,Willson, T.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2020-06-28, release date: 2020-07-29, Last modification date: 2024-01-31) |
Primary citation | Picado, A.,Chaikuad, A.,Wells, C.I.,Shrestha, S.,Zuercher, W.J.,Pickett, J.E.,Kwarcinski, F.E.,Sinha, P.,de Silva, C.S.,Zutshi, R.,Liu, S.,Kannan, N.,Knapp, S.,Drewry, D.H.,Willson, T.M. A Chemical Probe for Dark Kinase STK17B Derives Its Potency and High Selectivity through a Unique P-Loop Conformation. J.Med.Chem., 63:14626-14646, 2020 Cited by PubMed: 33215924DOI: 10.1021/acs.jmedchem.0c01174 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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