5I35

Structure of the Human mitochondrial kinase COQ8A R611K with AMPPNP (Cerebellar Ataxia and Ubiquinone Deficiency Through Loss of Unorthodox Kinase Activity)

Summary for 5I35

• Entry DOI: 10.2210/pdb5i35/pdb
• Descriptor: Atypical kinase ADCK3, mitochondrial, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER (3 entities in total)
• Functional Keywords: mitochondrial protein, kinase, ubiquinone biosynthesis, ubib clade kinase, structural genomics, psi-2, protein structure initiative, mitochondrial protein partnership, mpp, transferase, adck3, coenzyme q biosynthesis, adck3_human
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 46429.56

Authors

Bingman, C.A.,Stefely, J.A.,Pagliarini, D.J.,Mitochondrial Protein Partnership (MPP) (deposition date: 2016-02-09, release date: 2016-08-17, Last modification date: 2019-12-25)

• Primary citation: Stefely, J.A.,Licitra, F.,Laredj, L.,Reidenbach, A.G.,Kemmerer, Z.A.,Grangeray, A.,Jaeg-Ehret, T.,Minogue, C.E.,Ulbrich, A.,Hutchins, P.D.,Wilkerson, E.M.,Ruan, Z.,Aydin, D.,Hebert, A.S.,Guo, X.,Freiberger, E.C.,Reutenauer, L.,Jochem, A.,Chergova, M.,Johnson, I.E.,Lohman, D.C.,Rush, M.J.,Kwiecien, N.W.,Singh, P.K.,Schlagowski, A.I.,Floyd, B.J.,Forsman, U.,Sindelar, P.J.,Westphall, M.S.,Pierrel, F.,Zoll, J.,Dal Peraro, M.,Kannan, N.,Bingman, C.A.,Coon, J.J.,Isope, P.,Puccio, H.,Pagliarini, D.J.; Cerebellar Ataxia and Coenzyme Q Deficiency through Loss of Unorthodox Kinase Activity.; Mol.Cell, 63:608-620, 2016; PubMed: 27499294; DOI: 10.1016/j.molcel.2016.06.030

Experimental method

X-RAY DIFFRACTION (2.3 Å)