7AKG
Crystal structure of STK17B with bound dovitinib
Summary for 7AKG
Entry DOI | 10.2210/pdb7akg/pdb |
Descriptor | Serine/threonine-protein kinase 17B, 1,2-ETHANEDIOL, 4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one, ... (4 entities in total) |
Functional Keywords | kinase, stk17b, inhibitor, structural genomics, structural genomics consortium, sgc, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 38029.85 |
Authors | Chaikuad, A.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2020-09-30, release date: 2020-12-02, Last modification date: 2024-01-31) |
Primary citation | Picado, A.,Chaikuad, A.,Wells, C.I.,Shrestha, S.,Zuercher, W.J.,Pickett, J.E.,Kwarcinski, F.E.,Sinha, P.,de Silva, C.S.,Zutshi, R.,Liu, S.,Kannan, N.,Knapp, S.,Drewry, D.H.,Willson, T.M. A Chemical Probe for Dark Kinase STK17B Derives Its Potency and High Selectivity through a Unique P-Loop Conformation. J.Med.Chem., 63:14626-14646, 2020 Cited by PubMed: 33215924DOI: 10.1021/acs.jmedchem.0c01174 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.08 Å) |
Structure validation
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