6P5S

HIPK2 kinase domain bound to CX-4945

Summary for 6P5S

• Entry DOI: 10.2210/pdb6p5s/pdb
• Descriptor: Homeodomain-interacting protein kinase 2, 5-[(3-chlorophenyl)amino]benzo[c][2,6]naphthyridine-8-carboxylic acid (3 entities in total)
• Functional Keywords: homeodomain interacting protein, kinase, p53 regulator, mitophagy, fibrosis, nuclear protein, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 45326.82

Authors

Agnew, C.,Liu, L.,Jura, N. (deposition date: 2019-05-30, release date: 2019-07-31, Last modification date: 2019-09-25)

• Primary citation: Agnew, C.,Liu, L.,Liu, S.,Xu, W.,You, L.,Yeung, W.,Kannan, N.,Jablons, D.,Jura, N.; The crystal structure of the protein kinase HIPK2 reveals a unique architecture of its CMGC-insert region.; J.Biol.Chem., 294:13545-13559, 2019; PubMed: 31341017; DOI: 10.1074/jbc.RA119.009725

Experimental method

X-RAY DIFFRACTION (2.194 Å)