6P5S
HIPK2 kinase domain bound to CX-4945
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Homeodomain-interacting protein kinase 2 | polymer | 390 | 44977.1 | 1 | UniProt (Q9H2X6) Pfam (PF00069) | Homo sapiens (Human) | hHIPk2 |
| 2 | B (A) | 5-[(3-chlorophenyl)amino]benzo[c][2,6]naphthyridine-8-carboxylic acid | non-polymer | 349.8 | 1 | Chemie (3NG) | |||
| 3 | C (A) | water | water | 18.0 | 65 | Chemie (HOH) |
Sequence modifications
A: 177 - 547 (UniProt: Q9H2X6)
| PDB | External Database | Details |
|---|---|---|
| Met 158 | - | initiating methionine |
| Gly 159 | - | expression tag |
| Ser 160 | - | expression tag |
| Ser 161 | - | expression tag |
| His 162 | - | expression tag |
| His 163 | - | expression tag |
| His 164 | - | expression tag |
| His 165 | - | expression tag |
| His 166 | - | expression tag |
| His 167 | - | expression tag |
| Ser 168 | - | expression tag |
| Ser 169 | - | expression tag |
| Gly 170 | - | expression tag |
| Glu 171 | - | expression tag |
| Asn 172 | - | expression tag |
| Leu 173 | - | expression tag |
| Tyr 174 | - | expression tag |
| Phe 175 | - | expression tag |
| Gln 176 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 44977.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 349.8 | |
| All* | Total formula weight | 45326.8 |
