6P5S

HIPK2 kinase domain bound to CX-4945

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Homeodomain-interacting protein kinase 2	polymer	390	44977.1	1	UniProt (Q9H2X6) Pfam (PF00069) In PDB	Homo sapiens (Human)	hHIPk2
2	A	5-[(3-chlorophenyl)amino]benzo[c][2,6]naphthyridine-8-carboxylic acid	non-polymer		349.8	1	Chemie (3NG)
3		water	water		18.0	65	Chemie (HOH)

Sequence modifications

A: 177 - 547 (UniProt: Q9H2X6)

PDB	External Database	Details
Met 158	-	initiating methionine
Gly 159	-	expression tag
Ser 160	-	expression tag
Ser 161	-	expression tag
His 162	-	expression tag
His 163	-	expression tag
His 164	-	expression tag
His 165	-	expression tag
His 166	-	expression tag
His 167	-	expression tag
Ser 168	-	expression tag
Ser 169	-	expression tag
Gly 170	-	expression tag
Glu 171	-	expression tag
Asn 172	-	expression tag
Leu 173	-	expression tag
Tyr 174	-	expression tag
Phe 175	-	expression tag
Gln 176	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	44977.1
Non-Polymers*	Number of molecules	1
	Total formula weight	349.8
All*	Total formula weight	45326.8

*Water molecules are not included.