6VC0

Crystal structure of the horse MLKL pseudokinase domain

Summary for 6VC0

Entry DOI	10.2210/pdb6vc0/pdb
Descriptor	Mixed lineage kinase domain like pseudokinase, GLYCEROL (3 entities in total)
Functional Keywords	cell death, necroptosis, pseudokinase, transferase
Biological source	Equus caballus (Horse)
Total number of polymer chains	3
Total formula weight	100195.48
Authors	Davies, K.A.,Czabotar, P.E. (deposition date: 2019-12-19, release date: 2020-07-08, Last modification date: 2023-10-11)
Primary citation	Davies, K.A.,Fitzgibbon, C.,Young, S.N.,Garnish, S.E.,Yeung, W.,Coursier, D.,Birkinshaw, R.W.,Sandow, J.J.,Lehmann, W.I.L.,Liang, L.Y.,Lucet, I.S.,Chalmers, J.D.,Patrick, W.M.,Kannan, N.,Petrie, E.J.,Czabotar, P.E.,Murphy, J.M. Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues. Nat Commun, 11:3060-3060, 2020 Cited by PubMed: 32561735 DOI: 10.1038/s41467-020-16823-3 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.746 Å)

Structure validation