6VC0
Crystal structure of the horse MLKL pseudokinase domain
Summary for 6VC0
Entry DOI | 10.2210/pdb6vc0/pdb |
Descriptor | Mixed lineage kinase domain like pseudokinase, GLYCEROL (3 entities in total) |
Functional Keywords | cell death, necroptosis, pseudokinase, transferase |
Biological source | Equus caballus (Horse) |
Total number of polymer chains | 3 |
Total formula weight | 100195.48 |
Authors | Davies, K.A.,Czabotar, P.E. (deposition date: 2019-12-19, release date: 2020-07-08, Last modification date: 2023-10-11) |
Primary citation | Davies, K.A.,Fitzgibbon, C.,Young, S.N.,Garnish, S.E.,Yeung, W.,Coursier, D.,Birkinshaw, R.W.,Sandow, J.J.,Lehmann, W.I.L.,Liang, L.Y.,Lucet, I.S.,Chalmers, J.D.,Patrick, W.M.,Kannan, N.,Petrie, E.J.,Czabotar, P.E.,Murphy, J.M. Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues. Nat Commun, 11:3060-3060, 2020 Cited by PubMed: 32561735DOI: 10.1038/s41467-020-16823-3 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.746 Å) |
Structure validation
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