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6BPL
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BU of 6bpl by Molmil
E. coli MsbA in complex with LPS and inhibitor G907
Descriptor: (2E)-3-{6-[(1S)-1-(2-chloro-6-cyclopropylphenyl)ethoxy]-4-cyclopropylquinolin-3-yl}prop-2-enoic acid, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, 2-amino-2-deoxy-alpha-D-glucopyranose, ...
Authors:Ho, H, Koth, C.M, Payandeh, J.
Deposit date:2017-11-23
Release date:2018-05-02
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.908 Å)
Cite:Structural basis for dual-mode inhibition of the ABC transporter MsbA.
Nature, 557, 2018
6BPP
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BU of 6bpp by Molmil
E. coli MsbA in complex with LPS and inhibitor G092
Descriptor: (2E)-3-{6-[(1S)-1-(3-amino-2,6-dichlorophenyl)ethoxy]-4-cyclopropylquinolin-3-yl}prop-2-enoic acid, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 3-HYDROXY-TETRADECANOIC ACID, ...
Authors:Ho, H, Koth, C.M, Payandeh, J.
Deposit date:2017-11-24
Release date:2018-05-02
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.92 Å)
Cite:Structural basis for dual-mode inhibition of the ABC transporter MsbA.
Nature, 557, 2018
8C1P
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BU of 8c1p by Molmil
Active state homomeric GluA1 AMPA receptor in complex with TARP gamma 3
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CYCLOTHIAZIDE, ...
Authors:Zhang, D, Ivica, J, Krieger, J.M, Ho, H, Yamashita, K, Cais, O, Greger, I.
Deposit date:2022-12-21
Release date:2023-08-30
Last modified:2023-10-11
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor.
Nature, 621, 2023
8C2H
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BU of 8c2h by Molmil
Transmembrane domain of active state homomeric GluA1 AMPA receptor in tandem with TARP gamma 3
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Glutamate receptor 1 flip isoform, ...
Authors:Zhang, D, Ivica, J, Krieger, J.M, Ho, H, Yamashita, K, Cais, O, Greger, I.
Deposit date:2022-12-22
Release date:2023-08-30
Last modified:2023-10-11
Method:ELECTRON MICROSCOPY (2.64 Å)
Cite:Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor.
Nature, 621, 2023
8C2I
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BU of 8c2i by Molmil
Transmembrane domain of resting state homomeric GluA1 AMPA receptor in complex with TARP gamma 3
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Glutamate receptor 1 flip isoform, ...
Authors:Zhang, D, Ivica, J, Krieger, J.M, Ho, H, Yamashita, K, Cais, O, Greger, I.
Deposit date:2022-12-22
Release date:2023-08-30
Last modified:2023-10-11
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor.
Nature, 621, 2023
8C1S
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BU of 8c1s by Molmil
Transmembrane domain of resting state homomeric GluA2 F231A mutant AMPA receptor in complex with TARP gamma 2
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Glutamate receptor 2, ...
Authors:Zhang, D, Ivica, J, Krieger, J.M, Ho, H, Yamashita, K, Cais, O, Greger, I.
Deposit date:2022-12-21
Release date:2023-08-30
Last modified:2023-10-11
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor.
Nature, 621, 2023
8C1R
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BU of 8c1r by Molmil
Resting state homomeric GluA2 F231A mutant AMPA receptor in complex with TARP gamma-2
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Glutamate receptor 2, ...
Authors:Zhang, D, Ivica, J, Krieger, J.M, Ho, H, Yamashita, K, Cais, O, Greger, I.
Deposit date:2022-12-21
Release date:2023-08-30
Last modified:2023-10-11
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor.
Nature, 621, 2023
8C1Q
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BU of 8c1q by Molmil
Resting state homomeric GluA1 AMPA receptor in complex with TARP gamma 3
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Glutamate receptor 1 flip isoform, ...
Authors:Zhang, D, Ivica, J, Krieger, J.M, Ho, H, Yamashita, K, Cais, O, Greger, I.
Deposit date:2022-12-21
Release date:2023-08-30
Last modified:2023-10-11
Method:ELECTRON MICROSCOPY (2.82 Å)
Cite:Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor.
Nature, 621, 2023
7QHH
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BU of 7qhh by Molmil
Desensitized state of GluA1/2 AMPA receptor in complex with TARP-gamma 8 (TMD-LBD)
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (7Z)-hexadec-7-enoate, GLUTAMIC ACID, ...
Authors:Herguedas, B, Kohegyi, B, Dohrke, J.N, Watson, J.F, Zhang, D, Ho, H, Shaikh, S, Lape, R, Krieger, J.M, Greger, I.H.
Deposit date:2021-12-12
Release date:2022-02-23
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Mechanisms underlying TARP modulation of the GluA1/2-gamma 8 AMPA receptor.
Nat Commun, 13, 2022
7T4Q
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BU of 7t4q by Molmil
CryoEM structure of the HCMV Pentamer gH/gL/UL128/UL130/UL131A in complex with neutralizing fabs 2C12, 7I13 and 13H11
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein H, Envelope glycoprotein L, ...
Authors:Kschonsak, M, Johnson, M.C, Schelling, R, Green, E.M, Rouge, L, Ho, H, Patel, N, Kilic, C, Kraft, E, Arthur, C.P, Rohou, A.L, Comps-Agrar, L, Martinez-Martin, N, Perez, L, Payandeh, J, Ciferri, C.
Deposit date:2021-12-10
Release date:2022-03-23
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural basis for HCMV Pentamer receptor recognition and antibody neutralization.
Sci Adv, 8, 2022
7T4S
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BU of 7t4s by Molmil
CryoEM structure of the HCMV Pentamer gH/gL/UL128/UL130/UL131A in complex with NRP2 and neutralizing fabs 8I21 and 13H11
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Envelope glycoprotein H, ...
Authors:Kschonsak, M, Johnson, M.C, Schelling, R, Green, E.M, Rouge, L, Ho, H, Patel, N, Kilic, C, Kraft, E, Arthur, C.P, Rohou, A.L, Comps-Agrar, L, Martinez-Martin, N, Perez, L, Payandeh, J, Ciferri, C.
Deposit date:2021-12-10
Release date:2022-03-23
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis for HCMV Pentamer receptor recognition and antibody neutralization.
Sci Adv, 8, 2022
7T4R
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BU of 7t4r by Molmil
CryoEM structure of the HCMV Pentamer gH/gL/UL128/UL130/UL131A in complex with THBD and neutralizing fabs MSL-109 and 13H11
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein H, Envelope glycoprotein L, ...
Authors:Kschonsak, M, Johnson, M.C, Schelling, R, Green, E.M, Rouge, L, Ho, H, Patel, N, Kilic, C, Kraft, E, Arthur, C.P, Rohou, A.L, Comps-Agrar, L, Martinez-Martin, N, Perez, L, Payandeh, J, Ciferri, C.
Deposit date:2021-12-10
Release date:2022-03-23
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural basis for HCMV Pentamer receptor recognition and antibody neutralization.
Sci Adv, 8, 2022
7JWP
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BU of 7jwp by Molmil
Fab CJ11 in complex IL-18 peptide liberated by Caspase cleavage
Descriptor: Fab CJ11 Heavy chain, Fab CJ11 Light chain, IL-18 peptide
Authors:Payandeh, J, Ho, H.
Deposit date:2020-08-26
Release date:2021-03-24
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3 Å)
Cite:Discovery of a caspase cleavage motif antibody reveals insights into noncanonical inflammasome function.
Proc.Natl.Acad.Sci.USA, 118, 2021
7JWQ
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BU of 7jwq by Molmil
Fab CJ11 in complex IL-1beta peptide liberated by Caspase cleavage
Descriptor: Fab CJ11 Heavy chain, Fab CJ11 Light chain, IL-1beta peptide
Authors:Payandeh, J, Ho, H.
Deposit date:2020-08-26
Release date:2021-03-24
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.001 Å)
Cite:Discovery of a caspase cleavage motif antibody reveals insights into noncanonical inflammasome function.
Proc.Natl.Acad.Sci.USA, 118, 2021
7Y19
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BU of 7y19 by Molmil
Transcriptional regulator BrpR
Descriptor: Transcriptional regulator VpsR
Authors:Ki, N, Ha, N.C, Seung-Ho, H.
Deposit date:2022-06-07
Release date:2023-07-05
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Structural basis for the biofilm regulation of transcription factor BrpR in Vibrio vulnificus
To Be Published
7SEL
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BU of 7sel by Molmil
E. coli MsbA in complex with LPS and inhibitor G7090 (compound 3)
Descriptor: (2E)-3-{7-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-1-methylnaphthalen-2-yl}prop-2-enoic acid, (2~{R},4~{R},5~{R},6~{R})-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-2-[(2~{R},4~{R},5~{R},6~{R})-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-2-carboxy-2-[[(2~{R},3~{S},4~{R},5~{R},6~{R})-5-[[(3~{R})-3-dodecanoyloxytetradecanoyl]amino]-6-[[(2~{R},3~{S},4~{R},5~{R},6~{R})-3-oxidanyl-5-[[(3~{R})-3-oxidanyltetradecanoyl]amino]-4-[(3~{R})-3-oxidanyltetradecanoyl]oxy-6-phosphonooxy-oxan-2-yl]methoxy]-3-phosphonooxy-4-[(3~{R})-3-tetradecanoyloxytetradecanoyl]oxy-oxan-2-yl]methoxy]-5-oxidanyl-oxan-4-yl]oxy-4,5-bis(oxidanyl)oxane-2-carboxylic acid, ATP-dependent lipid A-core flippase
Authors:Payandeh, J, Koth, C.M, Verma, V.A.
Deposit date:2021-09-30
Release date:2022-03-09
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.978 Å)
Cite:Discovery of Inhibitors of the Lipopolysaccharide Transporter MsbA: From a Screening Hit to Potent Wild-Type Gram-Negative Activity.
J.Med.Chem., 65, 2022
5FWY
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BU of 5fwy by Molmil
Crystal structure of the AMPA receptor GluA2/A3 N-terminal domain heterodimer
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLUTAMATE RECEPTOR 2, GLUTAMATE RECEPTOR 3, ...
Authors:Herguedas, B, Garcia-Nafria, J, Greger, I.H.
Deposit date:2016-02-21
Release date:2016-03-16
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Structure and Organization of Heteromeric Ampa-Type Glutamate Receptors.
Science, 352, 2016
5EK0
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BU of 5ek0 by Molmil
Human Nav1.7-VSD4-NavAb in complex with GX-936.
Descriptor: 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 3-cyano-4-[2-[2-(1-ethylazetidin-3-yl)pyrazol-3-yl]-4-(trifluoromethyl)phenoxy]-~{N}-(1,2,4-thiadiazol-5-yl)benzenesulfonamide, Chimera of bacterial Ion transport protein and human Sodium channel protein type 9 subunit alpha
Authors:Ahuja, S, Mukund, S, Starovasnik, M.A, Koth, C.M, Payandeh, J.
Deposit date:2015-11-03
Release date:2015-12-23
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.53 Å)
Cite:Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist.
Science, 350, 2015
7QHB
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BU of 7qhb by Molmil
Active state of GluA1/2 in complex with TARP gamma 8, L-glutamate and CTZ
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (7Z)-hexadec-7-enoate, CYCLOTHIAZIDE, ...
Authors:Herguedas, B, Kohegyi, B, Zhang, D, Greger, I.H.
Deposit date:2021-12-11
Release date:2022-02-23
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Mechanisms underlying TARP modulation of the GluA1/2-gamma 8 AMPA receptor.
Nat Commun, 13, 2022
6QKZ
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BU of 6qkz by Molmil
Full length GluA1/2-gamma8 complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 6-nitro-2,3-bis(oxidanylidene)-1,4-dihydrobenzo[f]quinoxaline-7-sulfonamide, ...
Authors:Herguedas, B, Garcia-Nafria, J, Greger, I.G.
Deposit date:2019-01-30
Release date:2019-03-27
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (6.3 Å)
Cite:Architecture of the heteromeric GluA1/2 AMPA receptor in complex with the auxiliary subunit TARP gamma 8.
Science, 364, 2019
6QKC
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BU of 6qkc by Molmil
GluA1/2 In complex with auxiliary subunit gamma-8
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 6-nitro-2,3-bis(oxidanylidene)-1,4-dihydrobenzo[f]quinoxaline-7-sulfonamide, Glutamate receptor 1, ...
Authors:Herguedas, B, Garcia-Nafria, J, Greger, I.G.
Deposit date:2019-01-28
Release date:2019-03-27
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Architecture of the heteromeric GluA1/2 AMPA receptor in complex with the auxiliary subunit TARP gamma 8.
Science, 364, 2019
5IXI
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BU of 5ixi by Molmil
Structure of human JAK1 FERM/SH2 in complex with IFNLR1/IL10RA chimera
Descriptor: Chimera protein of Interferon lambda receptor 1 and Interleukin-10 receptor subunit alpha, Tyrosine-protein kinase JAK1
Authors:Ferrao, R, Wallweber, H.J.A, Lupardus, P.J.
Deposit date:2016-03-23
Release date:2016-05-18
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.57 Å)
Cite:The Structural Basis for Class II Cytokine Receptor Recognition by JAK1.
Structure, 24, 2016
7U8G
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BU of 7u8g by Molmil
Cryo-EM structure of the core human NADPH oxidase NOX2
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 7G5 - heavy chain, ...
Authors:Noreng, S, Ota, N, Sun, Y, Masureel, M, Payandeh, J, Yi, T, Koerber, J.T.
Deposit date:2022-03-08
Release date:2022-10-26
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structure of the core human NADPH oxidase NOX2.
Nat Commun, 13, 2022
8TLM
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BU of 8tlm by Molmil
Structure of a class A GPCR/Fab complex
Descriptor: C-C chemokine receptor type 8, Green fluorescent protein fusion, Fab heavy chain, ...
Authors:Sun, D, Johnson, M, Masureel, M.
Deposit date:2023-07-27
Release date:2023-12-20
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural basis of antibody inhibition and chemokine activation of the human CC chemokine receptor 8.
Nat Commun, 14, 2023
8U1U
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BU of 8u1u by Molmil
Structure of a class A GPCR/agonist complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, C-C motif chemokine 1,C-C chemokine receptor type 8,EGFP fusion protein, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Sun, D, Johnson, M, Masureel, M.
Deposit date:2023-09-02
Release date:2023-12-20
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis of antibody inhibition and chemokine activation of the human CC chemokine receptor 8.
Nat Commun, 14, 2023

 

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